2012
Warm Body Temperature Facilitates Energy Efficient Cortical Action Potentials
Yu Y, Hill A, McCormick D. Warm Body Temperature Facilitates Energy Efficient Cortical Action Potentials. PLOS Computational Biology 2012, 8: e1002456. PMID: 22511855, PMCID: PMC3325181, DOI: 10.1371/journal.pcbi.1002456.Peer-Reviewed Original ResearchConceptsAction potentialsFiring rateBody temperatureFunctional brain imaging signalsAction potential durationSingle action potentialCortical action potentialsAction potential generationNormal body temperatureSpike firing rateAverage firing rateSpike afterhyperpolarizationEfficient neural codesPotential durationBrain imaging signalsMarked reductionChannel inactivationPotential generationNeural signal transmissionBrain architectureWarmer body temperaturesImaging signalsNeural codeDurationAfterhyperpolarization
2007
Selective control of cortical axonal spikes by a slowly inactivating K+ current
Shu Y, Yu Y, Yang J, McCormick D. Selective control of cortical axonal spikes by a slowly inactivating K+ current. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 11453-11458. PMID: 17581873, PMCID: PMC2040919, DOI: 10.1073/pnas.0702041104.Peer-Reviewed Original ResearchConceptsSpike durationLayer 5 pyramidal cellsWhole-cell recordingsIntracortical processingPyramidal cellsIntracortical axonsLow dosesDistal axonsAxonal spikesRepetitive dischargesAxonsMembrane potential changesRemarkable differential expressionSomaDifferential expressionAlpha subunitIonic channelsSmall increaseKv1.2 alpha subunitsDurationNeuronsDoses