2022
Experimental VX2 Rabbit Liver Tumor Model in Carbon Tetrachloride–Induced Cirrhosis of the Liver
Santana J, Shewarega A, Nam D, Kahl V, Madoff D, Zhang X, Chapiro J. Experimental VX2 Rabbit Liver Tumor Model in Carbon Tetrachloride–Induced Cirrhosis of the Liver. Journal Of Vascular And Interventional Radiology 2022, 34: 404-408.e1. PMID: 36473611, PMCID: PMC11037556, DOI: 10.1016/j.jvir.2022.11.026.Peer-Reviewed Original ResearchConceptsLiver cirrhosisMale New Zealand white rabbitsRabbit liver tumor modelCirrhotic liver backgroundReproducible tumor growthVX2 liver cancerLeft hepatic lobeNew Zealand white rabbitsDuration of treatmentLiver tumor modelCross-sectional imagingVX2 rabbit liver tumor modelZealand white rabbitsHepatic lobeHistopathological evaluationMajor underlying factorHepatic tumorsIntragastric administrationHepatocellular carcinomaLiver tumorsLiver cancerCirrhosisUnmet needTumor growthVX2 tumorsMachine Learning Models for Prediction of Posttreatment Recurrence in Early-Stage Hepatocellular Carcinoma Using Pretreatment Clinical and MRI Features: A Proof-of-Concept Study.
Iseke S, Zeevi T, Kucukkaya AS, Raju R, Gross M, Haider SP, Petukhova-Greenstein A, Kuhn TN, Lin M, Nowak M, Cooper K, Thomas E, Weber MA, Madoff DC, Staib L, Batra R, Chapiro J. Machine Learning Models for Prediction of Posttreatment Recurrence in Early-Stage Hepatocellular Carcinoma Using Pretreatment Clinical and MRI Features: A Proof-of-Concept Study. American Journal Of Roentgenology 2022, 220: 245-255. PMID: 35975886, PMCID: PMC10015590, DOI: 10.2214/ajr.22.28077.Peer-Reviewed Original ResearchConceptsEarly-stage hepatocellular carcinomaLiver transplantHepatocellular carcinomaImaging featuresPosttreatment recurrenceOrgan allocationMean AUCLiver transplant eligibilityPretreatment clinical characteristicsPretreatment MRI examinationsKaplan-Meier analysisKaplan-Meier curvesClinical characteristicsImaging surveillanceTherapy allocationTransplant eligibilityUnderwent treatmentClinical parametersRetrospective studyUnpredictable complicationMRI dataConcept studyPoor survivalClinical impactPretreatment MRI
2021
Thermal ablation alone vs thermal ablation combined with transarterial chemoembolization for patients with small (<3 cm) hepatocellular carcinoma
Chai NX, Chapiro J, Petukhova A, Gross M, Kucukkaya A, Raju R, Zeevi T, Elbanan M, Lin M, Perez-Lozada JC, Schlachter T, Strazzabosco M, Pollak JS, Madoff DC. Thermal ablation alone vs thermal ablation combined with transarterial chemoembolization for patients with small (<3 cm) hepatocellular carcinoma. Clinical Imaging 2021, 76: 123-129. PMID: 33592550, PMCID: PMC8217099, DOI: 10.1016/j.clinimag.2021.01.043.Peer-Reviewed Original ResearchConceptsOverall survivalTransarterial chemoembolizationHepatocellular carcinomaThermal ablationTA groupEarly-stage hepatocellular carcinomaMedian overall survivalTherapy-naïve patientsKaplan-Meier analysisMaximum tumor diameterStage hepatocellular carcinomaLog-rank testDrug-eluting beadsSmall hepatocellular carcinomaTerms of TTPHIPAA-compliant IRBSignificant differencesLipiodol-TACELocoregional therapyBCLC stageComplication rateTreatment cohortsTumor diameterAFP levelsPatient group
2020
Is There a Role for Combination, Single-Session Selective Transarterial Embolization and Microwave Ablation for Large Renal Masses?
LaRussa S, Vanden Berg RW, Craig KM, Madoff DC, McClure TD. Is There a Role for Combination, Single-Session Selective Transarterial Embolization and Microwave Ablation for Large Renal Masses? CardioVascular And Interventional Radiology 2020, 43: 1468-1473. PMID: 32613266, DOI: 10.1007/s00270-020-02568-5.Peer-Reviewed Original ResearchConceptsLarge renal massTransarterial embolizationRenal tumorsRenal massesMicrowave ablationCharleston Comorbidity IndexLarge renal tumorsEvidence of recurrencePost-procedure complicationsAverage tumor sizeSelective transarterial embolizationSmall renal tumorsClear cell carcinomaMeeting inclusion criteriaPatient demographic informationGroin hematomaComorbidity indexResultsEleven patientsAverage BMICase seriesSuccessful ablationTumor sizeCell carcinomaMean ageRENAL scoreQuality of life after pharmacomechanical catheter-directed thrombolysis for proximal deep venous thrombosis
Kahn S, Julian J, Kearon C, Gu C, Cohen D, Magnuson E, Comerota A, Goldhaber S, Jaff M, Razavi M, Kindzelski A, Schneider J, Kim P, Chaer R, Sista A, McLafferty R, Kaufman J, Wible B, Blinder M, Vedantham S, Sichlau M, Vlahos A, Smith S, Thalheimer Q, Singh N, Harting R, Gocke J, Guth S, Shah N, Brady P, Schatz M, Horrow M, Markazi P, Forouzan L, Matalon T, Hertzog D, Goday S, Kennedy M, Kaplan R, Campbell T, Hartman J, Nahum E, Venkat A, Krishnamurthy V, Rectenwald J, Henke P, Eliason J, Willatt J, Escobar G, Samuels S, Katzen B, Benenati J, Powell A, Pena C, Wallach H, Gandhi R, Schneider J, Kim S, Hashemi F, Boyle J, Patel N, Verta M, Leung D, Garcia M, Blatt P, Khatri J, Epstein D, Ryan R, Sweeny T, Stillabower M, Kimbiris G, Raman T, Sierzenski P, Getto L, Dignazio M, Sierzenski P, Horvath M, Gornik H, Bartholomew J, Shishehbor M, Peacock F, Joseph D, Kim S, Mahlay N, Clair D, Lyden S, Kapoor B, McLennon G, Pierce G, Newman J, Spain J, Gill A, Hamilton A, Rizzo A, Park W, Dietzek A, Galin I, Plummer D, Hsu R, Broderick P, Keller A, Sayeed S, Slater D, Lustberg H, Akus J, Sidman R, Dhami M, Kohanski P, Bulgaru A, Dulala R, Burch J, Kapur D, Yang J, Ranson M, Wladis A, Varnagy D, Mekhail T, Winter R, Perez-Izquierdo M, Motew S, Royd-Kranis R, Workman R, Kribbs S, Hogsette G, Moore P, Thomason B, Means W, Bonsall R, Stewart J, Golwya D, Azene E, Bottner W, Bishop W, Clayton D, Gundersen L, Riherd J, Shakhnovich I, Ziegelbein K, Chang T, Sharma K, Allison S, Banovac F, Cohen E, Furlong B, Kessler C, McCullough M, Spies J, Lin J, Kaatz S, Getzen T, Miller J, Schwartz S, Kabbani L, McVinnie D, Rundback J, Manno J, Schwab R, Cole R, Herman K, Singh D, Barkama R, Patel A, Comerota A, Pigott J, Seiwert A, Whalen R, Russell T, Assi Z, Kazanjian S, Yobbagy J, Kaminski B, Kaufman A, Begeman G, DiSalle R, Thakur S, Kim P, Jacquet M, Dykes T, Gerding J, Baker C, Debiasto M, Mittleider D, Higgins G, Amberson S, Pezzuti R, Gallagher T, Schainfeld R, Wicky S, Kalva S, Walker G, Salazar G, Pomerantz B, Patel V, Kabrhel C, Iqbal S, Gangull S, Oklu R, Brannan S, Misra S, Bjarnason H, Ashrani A, Caccavale M, Fleming C, Friese J, Heit J, Kalra M, Macedo T, McBane R, McKusick M, Stockland A, Woodrum D, Wysokinski W, Verma A, Davis A, Chung J, Nicker D, Anderson B, Stein R, Weiss M, Patel P, Rilling W, Tutton S, Hieb R, Hohenwalter E, Colella M, Gosset J, White S, Lewis B, Brown K, Rossi P, Seabrook G, Guimaraes M, Selby J, McGary W, Hannegan C, Robison J, Brothers T, Elliott B, Garg N, Anderson M, Uflacker R, Schonholz C, Raney L, Greenberg C, Kaufman J, Keller F, Kolbeck K, Landry G, Mitchell E, Barton R, DeLoughery T, Kalbfleisch N, Minjarez R, Lakin P, Liem T, Moneta G, Farsad K, Fleischman R, French L, Marques V, Al−Hassani Y, Sawar A, Taylor F, Patel R, Malhotra R, Kim D, Hashemi F, Boyle J, Patel R, Padnick M, Gurley M, Cucher F, Sterrenberg R, Deepthi G, Cumaranatunge G, Bhatla S, Jacobs D, Dolen E, Gamboa P, Dean L, Davis T, Lippert J, Khanna S, Schirf B, Silber J, Wood D, McGraw J, LaPerna L, Willette P, Murphy T, Cerezo J, Dhangana R, Ahn S, Dubel G, Haas R, Jay B, Prince E, Soares G, Klinger J, Lambiase R, Jay G, Tubbs R, Beland M, Hampson C, O'Hara R, Thompson C, Beland M, Frodsham A, Gardiner F, Jaffan A, Keating L, Zafar A, Alicic R, Raabe R, Brower J, McClellan D, Pellow T, Zylak C, Davis J, Reilly M, Symington K, Seibold C, Nachreiner R, Murray D, Murray S, Saha S, Luna G, Hodgson K, McLafferty R, Hood D, Moore C, Griffen D, Hurst D, Lubbers D, Kim K, Warren B, Engel J, Suresh D, VanderWoude E, Razdan R, Hutchins M, Rounsborg T, Midathada M, Moravec D, Tilford J, Kim D, Beckman J, Razavi M, Openshaw K, Flanigan D, Loh C, Dorne H, Chan M, Thomas J, Psaila J, Ringold M, Fisher J, Lipcomb A, Oskin T, Wible B, Coleman B, Elliott D, Gaddis G, Cochran C, Natarajan K, Bick S, Cooke J, Hedderman A, Greist A, Miller L, Martinez B, Flanders V, Underhill M, Hofmann L, Sze D, Kuo W, Louie J, Hwang G, Hovsepian D, Kothary N, Berube C, Schreiber D, Jeffrey B, Schor J, Deitch J, Singh K, Hahn B, Ardolic B, Gupta S, Bashir R, Rao A, Garg M, Patil P, Zack C, Cohen G, Schmieder F, Lakhter V, Sacks D, Guay R, Scott M, Cunningham K, Sigal A, Cescon T, Leasure N, Dhurairaj T, Muck P, Knochel K, Lohr J, Barreau J, Recht M, Bhaskaran J, Brahmamdam R, Draper D, Mehta A, Maher J, Sharafuddin M, Lentz S, Nugent A, Sharp W, Kresowik T, Nicholson R, Sun S, Youness F, Pascarella L, Ray C, Knuttinen M, Bui J, Gaba R, Dobiesz V, Shamim E, Nimmagadda S, Peace D, Zain A, Palumto A, Haskal Z, Hirshon J, Richard H, Verceles A, Wong-You-Chong J, Othee B, Patel R, Iliescu B, Williams D, Gemmete J, Krishnamurthy V, Cwikiel W, Cho K, Schields J, Vellody R, Novelli P, Dasika N, Wakefield T, Rectenwald J, Henke P, Desmond J, Froehlich J, Khaja M, Hunter D, Golzarian J, Cressman E, Dotta Y, Schmiechen N, Marek J, Garcia D, Tawil I, Langsfeld M, Moll S, Mauro M, Stavas J, Burke C, Dixon R, Yu H, Keagy B, Kim K, Kasthuri R, Key N, Chaer R, Makaroun M, Rhee R, Cho J, Baril D, Marone L, Hseih M, Feterik K, Smith R, Jeyabalan G, Rogers J, Vinik R, Kinikini D, Kraiss L, Mueller M, Pendleton R, Rondina M, Sarfati M, Wanner N, Johnson S, Hopkins C, Ihnat D, Angle J, Matsumoto A, Harthun N, Turba U, Saad W, Uthlaut B, Nannapaneni S, Ling D, Sabri S, Kern J, Macik B, Hoke G, Park A, Stone J, Sneed B, Syverud S, Davidson K, Sharma A, Haskal Z, Wilkins L, Black C, Asay M, Hatch D, Smilanich R, Patten C, Brown S, Nielsen R, Alward W, Collins J, Nokes M, Geary R, Edwards M, Godshall C, Levy P, Winokur R, Sista A, Madoff D, Lee K, Pua B, DeSancho M, Milizia R, Gao J, Goday S, Kennedy M, Kaplan R, Campbell T, McLean G, Hartman J, Nahum E, Khalid S, Vedantham S, Lewis L, Saad N, Thoelke M, Pallow R, Klein S, Sicard G, Cohen D, Comerota A, Gornik H, Jaff M, Julian J, Kahn S, Kearon C, Kee S, Kindzelski A, Lewis L, Magnuson E, Razavi M, Murphy T, Vedantham S. Quality of life after pharmacomechanical catheter-directed thrombolysis for proximal deep venous thrombosis. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2020, 8: 8-23.e18. PMID: 31843251, PMCID: PMC7681916, DOI: 10.1016/j.jvsv.2019.03.023.Peer-Reviewed Original ResearchConceptsPharmacomechanical catheter-directed thrombolysisProximal deep venous thrombosisDeep venous thrombosisQuality of lifeDisease-specific QOLIliofemoral deep venous thrombosisCatheter-directed thrombolysisPhysical component summaryVenous thrombosisPCDT groupChange scoresDVT patientsQOL measuresForm Health Survey Physical Component SummaryExtent of DVTLong-term QOLAssessor-blinded randomized trialGeneral QOL measuresVenous Insufficiency EpidemiologicalAcute venous thrombosisDisease-specific QOL measuresGreater improvementThrombolysis trialsCommon femoralComponent summary
2019
Applications of transcatheter embolotherapy in preparation for liver transplantation and resection
Lin EY, Cornman-Homonoff J, Odisio BC, Madoff DC. Applications of transcatheter embolotherapy in preparation for liver transplantation and resection. Chinese Clinical Oncology 2019, 8: 59. PMID: 31865716, DOI: 10.21037/cco.2019.12.03.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLocoregional therapyPost-resection outcomesLiver-directed therapiesAppropriate patient selectionEarly-stage diseasePre-operative periodMaximal potential benefitTranscatheter embolotherapyLiver transplantationPatient selectionSurgical interventionInterventional radiologyPartial hepatectomyTransplantationTherapyPotential benefitsResectionPatientsSurgeryEmbolotherapyHepatectomyDiseaseTranshepatic portal stent placement and jejunal varix embolization for management of treatment-limiting gastrointestinal bleeding in a patient with unresectable recurrent intrahepatic cholangiocarcinoma
Cornman-Homonoff J, Bassik N, Madoff DC. Transhepatic portal stent placement and jejunal varix embolization for management of treatment-limiting gastrointestinal bleeding in a patient with unresectable recurrent intrahepatic cholangiocarcinoma. Clinical Imaging 2019, 59: 188-191. PMID: 31837541, DOI: 10.1016/j.clinimag.2019.09.012.Peer-Reviewed Case Reports and Technical NotesConceptsRecurrent cholangiocarcinomaOnly potential cureRecurrent intrahepatic cholangiocarcinomaPoor patient outcomesUnresectable diseaseGastrointestinal bleedingChemotherapy administrationMyelosuppressive effectsTherapeutic mainstayDismal prognosisIntrahepatic cholangiocarcinomaVariceal embolizationStent placementPortal veinPatient outcomesPotential cureCholangiocarcinomaEmbolizationCytopeniasBleedingRegimenChemotherapyPatientsSurgeryPrognosisUse of Virtual Injection Software to Aid in Microcatheter Positioning during Transarterial Chemoembolization
Soliman MM, Stein SI, Doustaly R, Madoff DC. Use of Virtual Injection Software to Aid in Microcatheter Positioning during Transarterial Chemoembolization. Journal Of Vascular And Interventional Radiology 2019, 30: 1646-1648. PMID: 31471197, DOI: 10.1016/j.jvir.2019.07.003.Peer-Reviewed Original ResearchConceptsSoftwareInterventional radiology's role in the diagnosis and management of patients with gallbladder carcinoma.
Fine GC, Smith TA, Stein SI, Madoff DC. Interventional radiology's role in the diagnosis and management of patients with gallbladder carcinoma. Chinese Clinical Oncology 2019, 8: 40. PMID: 31431037, DOI: 10.21037/cco.2019.07.09.Peer-Reviewed Original ResearchConceptsPreoperative portal vein embolizationManagement of patientsGallbladder carcinomaAggressive biliary tract malignancyInterventional radiology’s roleLate disease statesPortal vein embolizationPost-operative complicationsBiliary tract malignancyCommon gastrointestinal malignancyBile leakGastrointestinal malignanciesSurgical candidatesVein embolizationBiliary drainageBiliary obstructionChronic painPorcelain gallbladderPercutaneous imageRisk factorsInterventional radiologistsPatientsCarcinomaTissue samplingDisease statesManagement of Advanced Stage Hepatocellular Carcinoma with Extensive Portal Vein Tumor Thrombus Using an Adjustable Dual Balloon Occlusion Technique
Madoff DC, Kim D, Holzwanger DJ, Kishore SA, Friedman T. Management of Advanced Stage Hepatocellular Carcinoma with Extensive Portal Vein Tumor Thrombus Using an Adjustable Dual Balloon Occlusion Technique. Journal Of Vascular And Interventional Radiology 2019, 30: 1145-1147. PMID: 31133450, DOI: 10.1016/j.jvir.2019.01.006.Peer-Reviewed Original ResearchBalloon-Assisted Transarterial Chemoembolization Segmentectomy: An Alternative Strategy in the Treatment of Hypovascular Oligometastatic Liver Metastases
Stein SI, Madoff DC. Balloon-Assisted Transarterial Chemoembolization Segmentectomy: An Alternative Strategy in the Treatment of Hypovascular Oligometastatic Liver Metastases. Journal Of Vascular And Interventional Radiology 2019, 30: 1143-1145. PMID: 31126788, DOI: 10.1016/j.jvir.2018.12.704.Peer-Reviewed Original ResearchBalloon-Assisted Blood Pressure Reduction in the Downstream Vascular Compartment to Avoid Nontarget Embolization during Transarterial Chemoembolization from the Inferior Phrenic Artery
Stein SI, Madoff DC. Balloon-Assisted Blood Pressure Reduction in the Downstream Vascular Compartment to Avoid Nontarget Embolization during Transarterial Chemoembolization from the Inferior Phrenic Artery. Journal Of Vascular And Interventional Radiology 2019, 30: 1642-1644. PMID: 31101418, DOI: 10.1016/j.jvir.2018.12.010.Peer-Reviewed Original ResearchExtrahepatic Clinical Application of Vessel Tracking Software and 3D Roadmapping Tools: Preliminary Experience
Sundararajan SH, McClure TD, Winokur RS, Kishore SA, Madoff DC. Extrahepatic Clinical Application of Vessel Tracking Software and 3D Roadmapping Tools: Preliminary Experience. Journal Of Vascular And Interventional Radiology 2019, 30: 1021-1026. PMID: 31003843, DOI: 10.1016/j.jvir.2018.11.039.Peer-Reviewed Original ResearchMeSH KeywordsAgedAneurysm, FalseCarcinoma, Renal CellComputed Tomography AngiographyEmbolization, TherapeuticFemaleGastrointestinal HemorrhageHumansImaging, Three-DimensionalKidney NeoplasmsMaleMesenteric Artery, SuperiorPancreaticoduodenectomyPostoperative HemorrhagePredictive Value of TestsPreliminary DataProstateProstatic HyperplasiaRadiographic Image Interpretation, Computer-AssistedRadiography, InterventionalRenal ArteryRetrospective StudiesSoftwareTreatment Outcome
2018
Direct Percutaneous Access and Coil Embolization for Management of Recurrent Jejunal Variceal Hemorrhage in the Setting of a Pre-Existing TIPS
Cornman-Homonoff J, Madoff DC. Direct Percutaneous Access and Coil Embolization for Management of Recurrent Jejunal Variceal Hemorrhage in the Setting of a Pre-Existing TIPS. Journal Of Vascular And Interventional Radiology 2018, 29: 1626-1629. PMID: 30368320, DOI: 10.1016/j.jvir.2018.05.007.Peer-Reviewed Case Reports and Technical NotesTreatment of Hepatic Tumors with Inaccessible Vasculature Using an Adjustable Length Dual Occlusion Balloon Catheter System
Madoff DC, Holzwanger DJ, Kishore SA, Friedman T. Treatment of Hepatic Tumors with Inaccessible Vasculature Using an Adjustable Length Dual Occlusion Balloon Catheter System. Journal Of Vascular And Interventional Radiology 2018, 29: 1300-1302. PMID: 30146204, DOI: 10.1016/j.jvir.2018.02.005.Peer-Reviewed Original Research
2017
Multicenter Trial of the VenaTech Convertible Vena Cava Filter
Hohenwalter EJ, Stone JR, O’Moore P, Smith SJ, Selby JB, Lewandowski RJ, Samuels S, Kiproff PM, Trost DW, Madoff DC, Handel J, Gandras EJ, Vlahos A, Rilling WS. Multicenter Trial of the VenaTech Convertible Vena Cava Filter. Journal Of Vascular And Interventional Radiology 2017, 28: 1353-1362. PMID: 28821379, DOI: 10.1016/j.jvir.2017.06.032.Peer-Reviewed Original ResearchConceptsVena cava filtersCava filtersDevice-related adverse eventsHigh-risk traumaAdverse event ratesSingle-arm studyFailure of anticoagulationTechnical success rateLong-term safetyConverted patientsAdverse eventsPulmonary embolismSurgical prophylaxisVenous thromboembolismMulticenter trialCaval filtersRight atriumSurgical removalClinical assessmentProcedure timePatientsEvent ratesMean timeSuccess rateMonths
2014
Characterization of In Vivo Ablation Zones Following Percutaneous Microwave Ablation of the Liver with Two Commercially Available Devices: Are Manufacturer Published Reference Values Useful?
Winokur RS, Du JY, Pua BB, Talenfeld AD, Sista AK, Schiffman MA, Trost DW, Madoff DC. Characterization of In Vivo Ablation Zones Following Percutaneous Microwave Ablation of the Liver with Two Commercially Available Devices: Are Manufacturer Published Reference Values Useful? Journal Of Vascular And Interventional Radiology 2014, 25: 1939-1946.e1. PMID: 25307296, DOI: 10.1016/j.jvir.2014.08.014.Peer-Reviewed Original ResearchBland embolization versus chemoembolization of hepatocellular carcinoma before transplantation
Kluger MD, Halazun KJ, Barroso RT, Fox AN, Olsen SK, Madoff DC, Siegel AB, Weintraub JL, Sussman J, Brown RS, Cherqui D, Emond JC. Bland embolization versus chemoembolization of hepatocellular carcinoma before transplantation. Liver Transplantation 2014, 20: 536-543. PMID: 24493271, PMCID: PMC4095977, DOI: 10.1002/lt.23846.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCarcinoma, HepatocellularCase-Control StudiesChemoembolization, TherapeuticDisease-Free SurvivalEnd Stage Liver DiseaseFemaleHumansKaplan-Meier EstimateLiver NeoplasmsLiver TransplantationMaleMiddle AgedNeoplasm Recurrence, LocalRetrospective StudiesTime FactorsTreatment OutcomeConceptsWait-list dropoutTAE patientsTACE patientsTransarterial embolizationTransarterial chemoembolizationHCC patientsEnd-stage liver disease (MELD) scoreSurvival rateRecurrence-free survival ratesMethods of embolizationRadiographic tumor sizeLiver Disease scoreOverall survival rateRecurrence-free survivalKaplan-Meier survivalBland transarterial embolizationCase-control studySignificant demographic differencesExplant tumorsPrimary endpointTreat basisTumor sizeHepatocellular carcinomaDisease scorePatients
2013
Percutaneous Intraportal Application of Adipose Tissue–derived Mesenchymal Stem Cells Using a Balloon Occlusion Catheter in a Porcine Model of Liver Fibrosis
Avritscher R, Abdelsalam ME, Javadi S, Ensor J, Wallace MJ, Alt E, Madoff DC, Vykoukal JV. Percutaneous Intraportal Application of Adipose Tissue–derived Mesenchymal Stem Cells Using a Balloon Occlusion Catheter in a Porcine Model of Liver Fibrosis. Journal Of Vascular And Interventional Radiology 2013, 24: 1871-1878. PMID: 24144538, DOI: 10.1016/j.jvir.2013.08.022.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAnimalsBalloon OcclusionBiomarkersBiopsyCell TrackingCells, CulturedEndovascular ProceduresEquipment DesignEthanolEthiodized OilGreen Fluorescent ProteinsHepatic VeinsLiverLiver Cirrhosis, ExperimentalMaleMesenchymal Stem Cell TransplantationMesenchymal Stem CellsSus scrofaTime FactorsTransfectionVascular Access DevicesVenous PressureConceptsHepatic venous pressure gradientBalloon occlusion catheterOcclusion catheterMesenchymal stem cellsLiver fibrosisLarge animal modelIntraportal applicationEndovascular approachPortal veinAdipose tissueAnimal modelsExperimental animalsPercutaneous endovascular approachVenous pressure gradientTranscatheter arterial embolizationNovel endovascular approachStem cellsPortal hypertensionVascular complicationsArterial embolizationLiver injuryLiver damageBiopsy specimensSham injectionBalloon inflation
2011
Phase I Trial of Hepatic Arterial Infusion of Nanoparticle Albumin–Bound Paclitaxel: Toxicity, Pharmacokinetics, and Activity
Fu S, Naing A, Moulder SL, Culotta KS, Madoff DC, Ng CS, Madden TL, Falchook GS, Hong DS, Kurzrock R. Phase I Trial of Hepatic Arterial Infusion of Nanoparticle Albumin–Bound Paclitaxel: Toxicity, Pharmacokinetics, and Activity. Molecular Cancer Therapeutics 2011, 10: 1300-1307. PMID: 21571911, DOI: 10.1158/1535-7163.mct-11-0259.Peer-Reviewed Original ResearchConceptsHepatic arterial infusionNab-paclitaxelHepatic extractionArterial infusionDose levelsNanoparticle Albumin-Bound PaclitaxelFirst-pass hepatic extractionPredominant liver metastasesCommon adverse eventsAdvanced cancer patientsAlbumin-Bound PaclitaxelDose-limiting toxicityPeak concentrationHighest dose levelStable diseaseAdverse eventsLiver involvementLiver metastasesPartial responseI trialComparative pharmacokinetic studyHepatic metastasesPoor outcomeCancer patientsNanoparticle albumin