2017
Catheter-directed Intraportal Delivery of Endothelial Cell Therapy for Liver Regeneration: A Feasibility Study in a Large-Animal Model of Cirrhosis.
Lee KS, Santagostino SF, Li D, Ramjit A, Serrano K, Ginsberg MD, Ding BS, Rafii S, Madoff DC. Catheter-directed Intraportal Delivery of Endothelial Cell Therapy for Liver Regeneration: A Feasibility Study in a Large-Animal Model of Cirrhosis. Radiology 2017, 285: 114-123. PMID: 28498793, DOI: 10.1148/radiol.2017162617.Peer-Reviewed Original ResearchConceptsEndothelial cell therapyMean proliferation indexLiver endothelial cellsCell therapyEndothelial cellsIntraportal deliveryProliferation indexPorcine modelCatheter-directed deliveryTreatment of cirrhosisInduction of cirrhosisMasson's trichrome stainingUnpaired t-testLarge animal studiesAutologous cell therapyHepatic specimensHepatobiliary injuryTranscatheter infusionHepatic arteryFluorescence-activated cellPathologic examinationHepatic fibrosisDuctal damageLiver fibrosisSurrogate marker
2013
Evaluation of liver fibrosis and hepatic venous pressure gradient with MR elastography in a novel swine model of cirrhosis
Huang SY, Abdelsalam ME, Harmoush S, Ensor JE, Chetta JA, Hwang KP, Stafford RJ, Madoff DC, Avritscher R. Evaluation of liver fibrosis and hepatic venous pressure gradient with MR elastography in a novel swine model of cirrhosis. Journal Of Magnetic Resonance Imaging 2013, 39: 590-597. PMID: 24532376, DOI: 10.1002/jmri.24189.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientVenous pressure gradientLiver stiffnessLiver fibrosisSwine modelExperimental animalsMR elastographyHigher liver stiffnessMean fibrosis scoreNovel swine modelReliable noninvasive techniquePositive correlationLiver cirrhosisTransarterial embolizationFibrosis scoreCirrhosisFibrosisExperimental swineSignificant positive correlationNoninvasive technique