2024
AI-driven Patient-Selection For Preoperative Portal Vein Embolization For Patients With Colorectal Cancer Liver Metastases
Kuhn T, Engelhardt W, Kahl V, Alkukhun A, Gross M, Iseke S, Onofrey J, Covey A, Camacho Vasquez J, Kawaguchi Y, Hasegawa K, Odisio B, Vauthey J, Antoch G, Chapiro J, Madoff D. AI-driven Patient-Selection For Preoperative Portal Vein Embolization For Patients With Colorectal Cancer Liver Metastases. Journal Of Vascular And Interventional Radiology 2024 PMID: 39638087, DOI: 10.1016/j.jvir.2024.11.025.Peer-Reviewed Original ResearchTotal liver volumeMetastatic colorectal cancer patientsPreoperative portal vein embolizationColorectal cancer liver metastasesPortal vein embolizationCancer liver metastasesMulticenter retrospective studyColorectal cancer patientsStudent's t-testBoard-certified radiologistsVein embolizationConsecutive patientsLiver metastasesLiver volumePatient selectionRetrospective studyCancer patientsRadiomic featuresInclusion criteriaPatientsSemi-automatic segmentationLab valuesT-testSDAUCImage-guided percutaneous strategies to improve the resectability of HCC: Portal vein embolization, liver venous deprivation, or radiation lobectomy?
Chan S, Cornman-Homonoff J, Lucatelli P, Madoff D. Image-guided percutaneous strategies to improve the resectability of HCC: Portal vein embolization, liver venous deprivation, or radiation lobectomy? Clinical Imaging 2024, 111: 110185. PMID: 38781614, DOI: 10.1016/j.clinimag.2024.110185.Peer-Reviewed Original ResearchLiver venous deprivationPortal vein embolizationRadiation lobectomyVein embolizationResection of HCCMinimally invasive techniquesStandard of careHepatic malignanciesLiver remnantLiver insufficiencySurgical candidacySurgical techniqueHepatocellular carcinomaInvasive techniquesHepatic functionPercutaneous strategiesResectionPatient's likelihoodLobectomyEmbolizationLiverPatientsFLRCarcinomaMalignancy
2023
Hepatic Hypertrophy in Normal and Cirrhotic Livers Following Portal Vein Embolization: Comparative Assessment of 2 Different Embolic Regimens in a Large Animal Model
Kuhn T, Kahl V, Wang Y, Berz A, Shewarega A, Santana J, Antoch G, Chapiro J, Schlachter T, Madoff D. Hepatic Hypertrophy in Normal and Cirrhotic Livers Following Portal Vein Embolization: Comparative Assessment of 2 Different Embolic Regimens in a Large Animal Model. Journal Of Vascular And Interventional Radiology 2023, 34: 2162-2172.e2. PMID: 37634850, DOI: 10.1016/j.jvir.2023.08.024.Peer-Reviewed Original ResearchConceptsPortal vein embolizationFuture liver remnantVein embolizationLiver remnantCirrhotic liverStandardized future liver remnantNon-cirrhotic groupImmune cell infiltrationNon-cirrhotic liverN-butyl cyanoacrylateT-testFemale Yorkshire pigsLarge animal modelLarge animal studiesStudent's t-testCirrhotic groupEmbolized lobeBaseline percentageHepatic hypertrophyCell infiltrationBaseline CTKi-67Preclinical studiesInstitutional Animal CareFLR increase
2022
Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy
Korenblik R, Olij B, Aldrighetti LA, Hilal MA, Ahle M, Arslan B, van Baardewijk LJ, Baclija I, Bent C, Bertrand CL, Björnsson B, de Boer MT, de Boer SW, Bokkers RPH, Rinkes IHMB, Breitenstein S, Bruijnen RCG, Bruners P, Büchler MW, Camacho JC, Cappelli A, Carling U, Chan BKY, Chang DH, choi J, Font JC, Crawford M, Croagh D, Cugat E, Davis R, De Boo DW, De Cobelli F, De Wispelaere JF, van Delden OM, Delle M, Detry O, Díaz-Nieto R, Dili A, Erdmann JI, Fisher O, Fondevila C, Fretland Å, Borobia FG, Gelabert A, Gérard L, Giuliante F, Gobardhan PD, Gómez F, Grünberger T, Grünhagen DJ, Guitart J, Hagendoorn J, Heil J, Heise D, Herrero E, Hess GF, Hoffmann MH, Iezzi R, Imani F, Nguyen J, Jovine E, Kalff JC, Kazemier G, Kingham TP, Kleeff J, Kollmar O, Leclercq WKG, Ben SL, Lucidi V, MacDonald A, Madoff DC, Manekeller S, Martel G, Mehrabi A, Mehrzad H, Meijerink MR, Menon K, Metrakos P, Meyer C, Moelker A, Modi S, Montanari N, Navines J, Neumann UP, Peddu P, Primrose JN, Qu X, Raptis D, Ratti F, Ridouani F, Rogan C, Ronellenfitsch U, Ryan S, Sallemi C, Moragues JS, Sandström P, Sarriá L, Schnitzbauer A, Serenari M, Serrablo A, Smits MLJ, Sparrelid E, Spüntrup E, Stavrou GA, Sutcliffe RP, Tancredi I, Tasse JC, Udupa V, Valenti D, Fundora Y, Vogl TJ, Wang X, White SA, Wohlgemuth WA, Yu D, Zijlstra IAJ, Binkert CA, Bemelmans MHA, van der Leij C, Schadde E, van Dam RM. Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy. CardioVascular And Interventional Radiology 2022, 45: 1391-1398. PMID: 35790566, PMCID: PMC9458562, DOI: 10.1007/s00270-022-03176-1.Peer-Reviewed Original ResearchConceptsFuture liver remnant hypertrophyHepatic vein embolizationMulticenter prospective single-arm trialResectable colorectal cancer liver metastasesColorectal cancer liver metastasesProspective single-arm trialFeasibility of resectionCancer liver metastasesDisease-free survivalSingle-arm trialSmall FLRPrimary endpointSecondary endpointsFLR hypertrophyLiver metastasesOverall survivalProspective trialVein embolizationLiver functionSafety profileArm trialLiver volumeWeek 1Week 3Study centers
2021
Systematic Reviews and Meta-Analyses of Portal Vein Embolization, Associated Liver Partition and Portal Vein Ligation, and Radiation Lobectomy Outcomes in Hepatocellular Carcinoma Patients
Charalel RA, Sung J, Askin G, Jo J, Mitry M, Chung C, Tmanova L, Madoff DC. Systematic Reviews and Meta-Analyses of Portal Vein Embolization, Associated Liver Partition and Portal Vein Ligation, and Radiation Lobectomy Outcomes in Hepatocellular Carcinoma Patients. Current Oncology Reports 2021, 23: 135. PMID: 34716800, DOI: 10.1007/s11912-021-01075-1.Peer-Reviewed Original ResearchConceptsPortal vein embolizationAssociated liver partitionPortal vein ligationHepatocellular carcinoma patientsSystematic reviewVein embolizationCarcinoma patientsMajor complicationsPooled proportionVein ligationLiver partitionLow major complication rateMajor complication ratePurpose of ReviewToRandom-effects modelWeb of ScienceEffective hypertrophyFLR hypertrophyComplication rateOvid EmbaseCochrane LibraryHCC patientsLiver hypertrophyOvid MEDLINEInclusion criteria
2020
Improving the Safety of Major Resection for Hepatobiliary Malignancy: Portal Vein Embolization and Recent Innovations in Liver Regeneration Strategies
Madoff DC, Odisio BC, Schadde E, Gaba RC, Bennink RJ, van Gulik TM, Guiu B. Improving the Safety of Major Resection for Hepatobiliary Malignancy: Portal Vein Embolization and Recent Innovations in Liver Regeneration Strategies. Current Oncology Reports 2020, 22: 59. PMID: 32415401, DOI: 10.1007/s11912-020-00922-x.Peer-Reviewed Original ResearchConceptsPortal vein embolizationFuture liver remnantFLR hypertrophyMajor hepatectomyVein embolizationHepatobiliary malignanciesCT volumetryAppropriate surgical candidatesExtent of resectionPortal vein ligationRadiation lobectomyVenous deprivationMajor resectionPerformance statusSurgical candidatesComplication rateLiver diseaseVein ligationLiver partitionLiver remnantTumor typesPhysiological imagingResectionEmbolizationMalignancyPreparing for liver surgery with “Alphabet Soup”: PVE, ALPPS, TAE-PVE, LVD and RL
Kim D, Cornman-Homonoff J, Madoff DC. Preparing for liver surgery with “Alphabet Soup”: PVE, ALPPS, TAE-PVE, LVD and RL. HepatoBiliary Surgery And Nutrition 2020, 9: 136-151. PMID: 32355673, PMCID: PMC7188547, DOI: 10.21037/hbsn.2019.09.10.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPre-operative portal vein embolizationRadiation lobectomyVein embolizationPortal vein embolizationPortal vein ligationStandard of careVenous deprivationPostoperative prognosisVein ligationLiver partitionTreatment eligibilityLiver surgeryInadequate augmentationSurgical hepatectomyTumor progressionLiver growthRegenerative techniquesEmbolizationHepatectomyLobectomyALPPSSurgeryPrognosis
2019
Interventional radiology's role in the diagnosis and management of patients with gallbladder carcinoma.
Fine GC, Smith TA, Stein SI, Madoff DC. Interventional radiology's role in the diagnosis and management of patients with gallbladder carcinoma. Chinese Clinical Oncology 2019, 8: 40. PMID: 31431037, DOI: 10.21037/cco.2019.07.09.Peer-Reviewed Original ResearchConceptsPreoperative portal vein embolizationManagement of patientsGallbladder carcinomaAggressive biliary tract malignancyInterventional radiology’s roleLate disease statesPortal vein embolizationPost-operative complicationsBiliary tract malignancyCommon gastrointestinal malignancyBile leakGastrointestinal malignanciesSurgical candidatesVein embolizationBiliary drainageBiliary obstructionChronic painPorcelain gallbladderPercutaneous imageRisk factorsInterventional radiologistsPatientsCarcinomaTissue samplingDisease states
2017
Portal Vein Embolization in the Treatment of Metastatic Colorectal Cancer: Optimal Approach and Current Controversies
Gans D, Siegel C, Patel I, Tavri S, Madoff D, Sutter C. Portal Vein Embolization in the Treatment of Metastatic Colorectal Cancer: Optimal Approach and Current Controversies. Digestive Disease Interventions 2017, 01: 171-183. DOI: 10.1055/s-0037-1606204.Peer-Reviewed Original ResearchPreoperative portal vein embolizationMetastatic colorectal cancerPortal vein embolizationPortal vein ligationSurgical alternativeSurgical resectionVein embolizationVein ligationColorectal cancerResectable metastatic colorectal cancerColorectal carcinoma metastaticNew surgical alternativeResidual liver volumeSubsequent surgical resectionTreatment of patientsLiver volume measurementCurrent controversiesCarcinoma metastaticLiver metastasesMetastatic diseaseLobe hypertrophyPatient selectionProper liver functionLiver functionLiver partitionUpdate on Embolization Therapies for Hepatocellular Carcinoma
Kishore S, Friedman T, Madoff DC. Update on Embolization Therapies for Hepatocellular Carcinoma. Current Oncology Reports 2017, 19: 40. PMID: 28421483, DOI: 10.1007/s11912-017-0597-2.Peer-Reviewed Original ResearchConceptsEmbolization therapyHepatocellular carcinomaFuture liver remnant hypertrophyPortal vein tumor thrombusPlanned hepatic resectionStage C diseaseBCLC stage AEarly-stage patientsManagement of patientsSafety of resectionVein tumor thrombusRadiation lobectomyRadiation segmentectomyUnresectable HCCUnifocal diseaseHepatic resectionVein embolizationBCLC stageStage patientsSurvival benefitTumor thrombusAblative optionsB diseaseC diseaseDifferent therapies
2016
Preoperative portal vein embolization
Li D, Madoff D. Preoperative portal vein embolization. 2016, 176-192. DOI: 10.1017/cbo9781107338555.020.Peer-Reviewed Original ResearchCancer carePreoperative portal vein embolizationPortal vein embolizationComprehensive cancer careRecent clinical dataCancer management strategiesInterventional oncology proceduresInterventional oncology techniquesVein embolizationPalliative benefitTreatment algorithmInvasive image-guided proceduresClinical dataResponse assessmentInterventional radiologistsSide effectsOncology proceduresInterventional oncologyImage-guided proceduresArea of practiceMicrowave ablationTumor ablationIrreversible electroporationImage guidanceTherapyControversies of preoperative portal vein embolization
May BJ, Madoff DC. Controversies of preoperative portal vein embolization. Hepatic Oncology 2016, 3: 155-166. PMID: 30191035, PMCID: PMC6095422, DOI: 10.2217/hep-2015-0004.Peer-Reviewed Original ResearchPortal Venous Interventions: State of the Art
Madoff DC, Gaba RC, Weber CN, Clark TW, Saad WE. Portal Venous Interventions: State of the Art. Radiology 2016, 278: 333-353. PMID: 26789601, DOI: 10.1148/radiol.2015141858.Peer-Reviewed Original ResearchConceptsBalloon retrograde transvenous obliterationEnd-stage liver diseaseIntrahepatic portosystemic shunt placementPreoperative portal vein embolizationTransjugular intrahepatic portosystemic shunt placementPortal venous interventionsMajor hepatic resectionPortal vein embolizationPortosystemic shunt placementPortal venous systemRetrograde transvenous obliterationIslet cell transplantationHepatic resectionVein embolizationDiabetes mellitusVenous interventionsLiver diseaseShunt placementClinical manifestationsTransvenous obliterationCell transplantationVenous systemUntoward effectsLiver cancerCellular therapy
2013
Update on Portal Vein Embolization: Evidence-based Outcomes, Controversies, and Novel Strategies
May BJ, Talenfeld AD, Madoff DC. Update on Portal Vein Embolization: Evidence-based Outcomes, Controversies, and Novel Strategies. Journal Of Vascular And Interventional Radiology 2013, 24: 241-254. PMID: 23369559, DOI: 10.1016/j.jvir.2012.10.017.Peer-Reviewed Original ResearchConceptsPortal vein embolizationFuture liver remnantVein embolizationCurative hepatic resectionPortal blood flowNumber of patientsTumor-bearing liverRecent outcome dataEvidence-based outcomesPostoperative morbidityFLR hypertrophyHepatic resectionLiver remnantPatient outcomesBlood flowOutcome dataNovel strategyEmbolizationSurgeryTherapyOutcomesMorbidityResectionPatientsHypertrophy
2012
Portal Vein Embolization: Rationale, Technique, and Current Application
May B, Madoff D. Portal Vein Embolization: Rationale, Technique, and Current Application. Seminars In Interventional Radiology 2012, 29: 081-089. PMID: 23729977, PMCID: PMC3444878, DOI: 10.1055/s-0032-1312568.Peer-Reviewed Original ResearchPortal vein embolizationFuture liver remnantPreoperative portal vein embolizationCurative-intent resectionComplicated postoperative courseNumber of patientsPostoperative morbidityHepatic resectionPostoperative courseVein embolizationSurgical outcomesLiver remnantPortal bloodLiver segmentsResectionTherapyCurrent useTechnical considerationsEmbolizationMorbidityPatientsSurgeryHypertrophyBlood
2011
The Ipsilateral Approach for Right PVE with or Without Segment 4
Madoff D. The Ipsilateral Approach for Right PVE with or Without Segment 4. 2011, 151-158. DOI: 10.1007/978-1-84882-122-4_17.Peer-Reviewed Original ResearchPortal vein embolizationFuture liver remnantIpsilateral approachSmall future liver remnantRight portal vein embolizationContralateral liver hypertrophyMajor liver resectionStandard of careMajor hepatectomyLiver resectionVein embolizationSubsequent resectionLiver remnantLiver hypertrophyPortal systemResectionSegment 4Operator preferenceEmbolizationPatientsHypertrophyHepatectomyLiverCareComplications of Portal Vein Embolization
Kodama Y, Shaw C, Madoff D. Complications of Portal Vein Embolization. 2011, 159-168. DOI: 10.1007/978-1-84882-122-4_18.Peer-Reviewed Original ResearchPortal vein embolizationVein embolizationStrict patient selectionManagement of complicationsMajor hepatectomyAdverse eventsClinical presentationPatient selectionPotential complicationsEmbolization proceduresClinical successComplicationsEmbolizationHepatectomyComplex proceduresAccess approachMorbidityEtiologyMortalityIndications and Contraindications for Portal Vein Embolization
Madoff D, Vauthey J. Indications and Contraindications for Portal Vein Embolization. 2011, 123-128. DOI: 10.1007/978-1-84882-122-4_13.Peer-Reviewed Original ResearchPortal vein embolizationTotal liver volumeVein embolizationUse of PVEFuture liver remnant volumeLiver remnant volumePatient body sizeFLR volumePerioperative outcomesPatient ageSurgical candidatesLiver diseaseRemnant volumeSurgical interventionLiver volumeCT volumetryHealthy liverParticular patientPatientsContraindicationsEmbolizationAgeMultiple factorsCirrhosisComorbidities
2010
Portal Vein Embolization Prior to Resection
Madoff D, Avritscher R. Portal Vein Embolization Prior to Resection. 2010, 153-183. DOI: 10.1007/978-1-60327-522-4_11.Peer-Reviewed Original ResearchFuture liver remnantFunctional liver massHepatic failureLiver massNormal underlying liverExtended hospital stayMajor hepatic resectionChronic liver diseasePortal vein embolizationMajor technical complicationsFatal hepatic failureImportant risk factorPerioperative failureHospital stayHepatic resectionVein embolizationPerioperative careLiver diseaseUnderlying liverLiver remnantFluid retentionHepatobiliary neoplasiaRisk factorsHigh riskResection
2009
Three Hundred and One Consecutive Extended Right Hepatectomies
Kishi Y, Abdalla EK, Chun YS, Zorzi D, Madoff DC, Wallace MJ, Curley SA, Vauthey JN. Three Hundred and One Consecutive Extended Right Hepatectomies. Annals Of Surgery 2009, 127: 171-179. PMID: 19730239, DOI: 10.1097/sla.0b013e3181b674df.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBilirubinChildChi-Square DistributionEmbolization, TherapeuticEndpoint DeterminationFemaleHepatectomyHumansLiverLiver Function TestsLogistic ModelsMaleMiddle AgedOutcome and Process Assessment, Health CarePatient SelectionPortal VeinPostoperative ComplicationsPreoperative CareRetrospective StudiesRisk FactorsStatistics, NonparametricConceptsPreoperative portal vein embolizationPostoperative liver insufficiencySafe hepatic resectionPreoperative PVEExtended right hepatectomyLiver insufficiencyRight hepatectomyHepatic resectionPostoperative outcomesEnd pointLiver volumetryIntraoperative blood transfusionPrimary end pointSecondary end pointsLiver volume ratioPortal vein embolizationShort-term outcomesBody mass indexTotal liver volumeMultivariate logistic regressionFLR volumeFuture liverVein embolizationBlood transfusionConsecutive patients