2023
Hepatic Hypertrophy in Normal and Cirrhotic Livers Following Portal Vein Embolization: Comparative Assessment of 2 Different Embolic Regimens in a Large Animal Model
Kuhn T, Kahl V, Wang Y, Berz A, Shewarega A, Santana J, Antoch G, Chapiro J, Schlachter T, Madoff D. Hepatic Hypertrophy in Normal and Cirrhotic Livers Following Portal Vein Embolization: Comparative Assessment of 2 Different Embolic Regimens in a Large Animal Model. Journal Of Vascular And Interventional Radiology 2023, 34: 2162-2172.e2. PMID: 37634850, DOI: 10.1016/j.jvir.2023.08.024.Peer-Reviewed Original ResearchConceptsPortal vein embolizationFuture liver remnantVein embolizationLiver remnantCirrhotic liverStandardized future liver remnantNon-cirrhotic groupImmune cell infiltrationNon-cirrhotic liverN-butyl cyanoacrylateT-testFemale Yorkshire pigsLarge animal modelLarge animal studiesStudent's t-testCirrhotic groupEmbolized lobeBaseline percentageHepatic hypertrophyCell infiltrationBaseline CTKi-67Preclinical studiesInstitutional Animal CareFLR increase
2020
Improving the Safety of Major Resection for Hepatobiliary Malignancy: Portal Vein Embolization and Recent Innovations in Liver Regeneration Strategies
Madoff DC, Odisio BC, Schadde E, Gaba RC, Bennink RJ, van Gulik TM, Guiu B. Improving the Safety of Major Resection for Hepatobiliary Malignancy: Portal Vein Embolization and Recent Innovations in Liver Regeneration Strategies. Current Oncology Reports 2020, 22: 59. PMID: 32415401, DOI: 10.1007/s11912-020-00922-x.Peer-Reviewed Original ResearchConceptsPortal vein embolizationFuture liver remnantFLR hypertrophyMajor hepatectomyVein embolizationHepatobiliary malignanciesCT volumetryAppropriate surgical candidatesExtent of resectionPortal vein ligationRadiation lobectomyVenous deprivationMajor resectionPerformance statusSurgical candidatesComplication rateLiver diseaseVein ligationLiver partitionLiver remnantTumor typesPhysiological imagingResectionEmbolizationMalignancy
2013
Update on Portal Vein Embolization: Evidence-based Outcomes, Controversies, and Novel Strategies
May BJ, Talenfeld AD, Madoff DC. Update on Portal Vein Embolization: Evidence-based Outcomes, Controversies, and Novel Strategies. Journal Of Vascular And Interventional Radiology 2013, 24: 241-254. PMID: 23369559, DOI: 10.1016/j.jvir.2012.10.017.Peer-Reviewed Original ResearchConceptsPortal vein embolizationFuture liver remnantVein embolizationCurative hepatic resectionPortal blood flowNumber of patientsTumor-bearing liverRecent outcome dataEvidence-based outcomesPostoperative morbidityFLR hypertrophyHepatic resectionLiver remnantPatient outcomesBlood flowOutcome dataNovel strategyEmbolizationSurgeryTherapyOutcomesMorbidityResectionPatientsHypertrophy
2012
Portal Vein Embolization: Rationale, Technique, and Current Application
May B, Madoff D. Portal Vein Embolization: Rationale, Technique, and Current Application. Seminars In Interventional Radiology 2012, 29: 081-089. PMID: 23729977, PMCID: PMC3444878, DOI: 10.1055/s-0032-1312568.Peer-Reviewed Original ResearchPortal vein embolizationFuture liver remnantPreoperative portal vein embolizationCurative-intent resectionComplicated postoperative courseNumber of patientsPostoperative morbidityHepatic resectionPostoperative courseVein embolizationSurgical outcomesLiver remnantPortal bloodLiver segmentsResectionTherapyCurrent useTechnical considerationsEmbolizationMorbidityPatientsSurgeryHypertrophyBlood
2011
The Ipsilateral Approach for Right PVE with or Without Segment 4
Madoff D. The Ipsilateral Approach for Right PVE with or Without Segment 4. 2011, 151-158. DOI: 10.1007/978-1-84882-122-4_17.Peer-Reviewed Original ResearchPortal vein embolizationFuture liver remnantIpsilateral approachSmall future liver remnantRight portal vein embolizationContralateral liver hypertrophyMajor liver resectionStandard of careMajor hepatectomyLiver resectionVein embolizationSubsequent resectionLiver remnantLiver hypertrophyPortal systemResectionSegment 4Operator preferenceEmbolizationPatientsHypertrophyHepatectomyLiverCare
2010
Portal Vein Embolization Prior to Resection
Madoff D, Avritscher R. Portal Vein Embolization Prior to Resection. 2010, 153-183. DOI: 10.1007/978-1-60327-522-4_11.Peer-Reviewed Original ResearchFuture liver remnantFunctional liver massHepatic failureLiver massNormal underlying liverExtended hospital stayMajor hepatic resectionChronic liver diseasePortal vein embolizationMajor technical complicationsFatal hepatic failureImportant risk factorPerioperative failureHospital stayHepatic resectionVein embolizationPerioperative careLiver diseaseUnderlying liverLiver remnantFluid retentionHepatobiliary neoplasiaRisk factorsHigh riskResection
2008
Preoperative Portal Vein Embolization
Madoff D. Preoperative Portal Vein Embolization. 2008, 316-334. DOI: 10.1017/cbo9780511722226.029.Peer-Reviewed Original ResearchPreoperative portal vein embolizationFuture liver remnantPortal vein embolizationSmall remnant liverFunctional liver massVein embolizationLiver failureRemnant liverLiver massExtensive liver surgeryNon-embolized segmentsNormal underlying liverPerioperative liver failureMajor liver resectionExtended hospital stayFatal liver failureChronic liver diseaseMajor technical complicationsMetastatic liver tumorsStandard of careHepatobiliary centersHospital stayMajor hepatectomyPerioperative morbidityCurative hepatectomy
2005
Transhepatic Ipsilateral Right Portal Vein Embolization Extended to Segment IV: Improving Hypertrophy and Resection Outcomes with Spherical Particles and Coils
Madoff DC, Abdalla EK, Gupta S, Wu TT, Morris JS, Denys A, Wallace MJ, Morello FA, Ahrar K, Murthy R, Lunagomez S, Hicks ME, Vauthey JN. Transhepatic Ipsilateral Right Portal Vein Embolization Extended to Segment IV: Improving Hypertrophy and Resection Outcomes with Spherical Particles and Coils. Journal Of Vascular And Interventional Radiology 2005, 16: 215-225. PMID: 15713922, DOI: 10.1097/01.rvi.0000147067.79223.85.Peer-Reviewed Original ResearchMeSH KeywordsAcrylic ResinsAdultAgedBile Duct NeoplasmsCarcinoma, HepatocellularCause of DeathEmbolization, TherapeuticFemaleFollow-Up StudiesGelatinHepatectomyHumansHypertrophyLength of StayLiverLiver NeoplasmsMaleMicrospheresMiddle AgedPolyvinyl AlcoholPortal VeinRetrospective StudiesSafetyTomography, Spiral ComputedTreatment OutcomeConceptsTotal estimated liver volumeRight portal vein embolizationTris-acryl microspheresRight PVEPortal vein embolizationRight hepatectomyFLR volumeResection rateVein embolizationLiver volumeEstimated liver volumeMalignant hepatobiliary diseaseProgressive liver insufficiencyMedian hospital stayPercent of patientsExtended right hepatectomyResult of sepsisFuture liver remnantPostembolization syndromeTomographic volumetryHospital stayFLR hypertrophyPostoperative outcomesResection outcomesBiliary cancer
2003
Portal Vein Embolization with Polyvinyl Alcohol Particles and Coils in Preparation for Major Liver Resection for Hepatobiliary Malignancy: Safety and Effectiveness—Study in 26 Patients1
Madoff DC, Hicks ME, Abdalla EK, Morris JS, Vauthey JN. Portal Vein Embolization with Polyvinyl Alcohol Particles and Coils in Preparation for Major Liver Resection for Hepatobiliary Malignancy: Safety and Effectiveness—Study in 26 Patients1. Radiology 2003, 227: 251-60. PMID: 12616006, DOI: 10.1148/radiol.2271012010.Peer-Reviewed Original ResearchConceptsPreoperative portal vein embolizationFuture liver remnantMedian hospital stayPortal vein embolizationPolyvinyl alcohol particlesHepatobiliary malignanciesLobar hypertrophyHospital stayFLR hypertrophyHepatic resectionVein embolizationLiver volumeAlcohol particlesPreoperative PVERatio of FLRAdvanced hepatobiliary malignanciesEstimated liver volumePostprocedure complication rateMajor liver resectionUnderlying liver diseasePercutaneous transhepatic approachTotal liver volumePVA particlesPostembolization syndromeComplication rate