2018
Cutaneous immunohistochemical staining pattern of p53β isoforms
Ko CJ, Myung P, Leffell DJ, Bourdon JC. Cutaneous immunohistochemical staining pattern of p53β isoforms. Journal Of Clinical Pathology 2018, 71: 1120. PMID: 30305316, DOI: 10.1136/jclinpath-2018-205098.Peer-Reviewed Original ResearchConceptsSquamous tumorsMarkers of differentiationSquamous proliferationIsoforms of p53Mutational statusHair folliclesP53 pathwayDomain mutationsExact biological significanceP53Differentiated layersSkinP53 isoformsSuch mutationsIsoformsDifferent isoformsNumerous functionsTumorsCancerMutationsFolliclesBiological significance
1996
Frequent clones of p53-mutated keratinocytes in normal human skin
Jonason A, Kunala S, Price G, Restifo R, Spinelli H, Persing J, Leffell D, Tarone R, Brash D. Frequent clones of p53-mutated keratinocytes in normal human skin. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 14025-14029. PMID: 8943054, PMCID: PMC19488, DOI: 10.1073/pnas.93.24.14025.Peer-Reviewed Original ResearchConceptsP53-mutated keratinocytesNormal individualsSun-shielded skinSun-exposed skinNormal human skinHuman skinWhole-mount preparationsP53-mutated cellsCancer predictsDermal-epidermal junctionSubstantial burdenFrequent clonesClonal expansionHair folliclesGenetic hitsTumor promoterSkinKeratinocytesCells