The Preliminary Analysis of Circulating Human Papillomavirus DNA in a Phase III Trial of Concurrent Chemoradiation (CRT) with Intensity Modulated Proton Therapy (IMPT) vs. IMRT in Oropharyngeal Squamous Cell Carcinoma (OPSCC)
Wang L, Zhang Y, Ausat N, Hernandez M, Rosenthal D, Garden A, Ferrarotto R, Gunn G, Fuller C, Phan J, Morrison W, Lee A, Moreno A, Gross N, Spiotto M, Frank S. The Preliminary Analysis of Circulating Human Papillomavirus DNA in a Phase III Trial of Concurrent Chemoradiation (CRT) with Intensity Modulated Proton Therapy (IMPT) vs. IMRT in Oropharyngeal Squamous Cell Carcinoma (OPSCC). International Journal Of Radiation Oncology • Biology • Physics 2024, 120: s123-s124. DOI: 10.1016/j.ijrobp.2024.07.223.Peer-Reviewed Original ResearchOropharyngeal squamous cell carcinomaIntensity modulated proton therapyDNA scoreConcurrent chemoradiationTreatment failureNode dissectionInduction chemotherapyHuman papillomavirusHPV+ oropharyngeal squamous cell carcinomaHigh risk of treatment failurePhase III randomized trialRisk of treatment failureMulticenter phase III randomized trialPost-induction chemotherapyTreatment de-escalationHuman papillomavirus DNALymph node dissectionPhase III trialsSquamous cell carcinomaPotential of TFAJCC-7RT doseTumor controlTreatment toxicityPost-RTPhase III randomized trial of intensity-modulated proton therapy (IMPT) versus intensity-modulated photon therapy (IMRT) for the treatment of head and neck oropharyngeal carcinoma (OPC).
Frank S, Busse P, Rosenthal D, Hernandez M, Swanson D, Garden A, Sturgis E, Ferrarotto R, Gunn G, Patel S, LEE N, Lin A, Snider J, McDonald M, Henson C, Bajaj G, Kalman N, Parvathaneni U, Katz S, Foote R. Phase III randomized trial of intensity-modulated proton therapy (IMPT) versus intensity-modulated photon therapy (IMRT) for the treatment of head and neck oropharyngeal carcinoma (OPC). Journal Of Clinical Oncology 2024, 42: 6006-6006. DOI: 10.1200/jco.2024.42.16_suppl.6006.Peer-Reviewed Original ResearchProgression-free survivalProgression-free survival HROverall survivalOropharyngeal carcinomaInduction chemotherapyChemoradiation therapyGastrostomy-tube dependenceHazard ratioRate of progression-free survivalManagement of head and neck tumorsIntensity-modulated photon therapyReceipt of induction chemotherapyTreated with chemoradiation therapyIntensity-modulated proton therapySurgical lymph node dissectionHead and neck tumorsPhase III randomized trialWeight loss <5%Bilateral neck treatmentHuman papillomavirus statusLymph node dissectionTarget tumor volumeMedian follow-upDe-intensification strategiesIntent-to-treat