Featured Publications
A novel MGP mutation in a consanguineous family: Review of the clinical and molecular characteristics of Keutel syndrome
Hur DJ, Raymond GV, Kahler SG, Riegert‐Johnson D, Cohen BA, Boyadjiev SA. A novel MGP mutation in a consanguineous family: Review of the clinical and molecular characteristics of Keutel syndrome. American Journal Of Medical Genetics Part A 2005, 135A: 36-40. PMID: 15810001, DOI: 10.1002/ajmg.a.30680.Peer-Reviewed Original ResearchConceptsKeutel syndromeMatrix Gla protein geneOptic nerve atrophyRare autosomal recessive conditionMid-dermal elastolysisFunction mutationsBone morphogenetic protein-2Autosomal recessive conditionConsanguineous Arab familyAbnormal cartilage calcificationNerve atrophyAbnormal calcificationCardinal featuresCalcification inhibitorsWhite matterClinical phenotypeTypical manifestationsRecessive conditionSoft tissueExtracellular matrix proteinsAffected individualsCartilage calcificationProtein 2Consanguineous familyConsensus donor splice siteFrequency of Coronary Artery Disease in Patients Undergoing Peripheral Artery Disease Surgery
Hur DJ, Kizilgul M, Aung WW, Roussillon KC, Keeley EC. Frequency of Coronary Artery Disease in Patients Undergoing Peripheral Artery Disease Surgery. The American Journal Of Cardiology 2012, 110: 736-740. PMID: 22633203, PMCID: PMC3418448, DOI: 10.1016/j.amjcard.2012.04.059.Peer-Reviewed Original ResearchConceptsCoronary artery diseasePeripheral arterial diseaseConcomitant coronary artery diseasePreoperative coronary angiographyCarotid artery diseaseArtery diseaseCoronary angiographyCase seriesCoronary arteryObstructive coronary artery diseaseSevere carotid artery diseaseEpicardial coronary arteriesSimilar risk factorsAngiographic evidenceDisease surgeryPeripheral revascularizationArterial diseaseDiameter narrowingRisk factorsHigh prevalencePatientsSurgeryAngiographyDiseasePrevalenceSerial Native T1 Mapping to Monitor Cardiac Response to Treatment in Light-Chain Amyloidosis
Hur DJ, Dicks DL, Huber S, Mojibian HR, Meadows JL, Seropian SE, Baldassarre LA. Serial Native T1 Mapping to Monitor Cardiac Response to Treatment in Light-Chain Amyloidosis. Circulation Cardiovascular Imaging 2016, 9: e004770. PMID: 27682238, DOI: 10.1161/circimaging.116.004770.Peer-Reviewed Original ResearchAn assessment of transesophageal echocardiography studies rated as rarely appropriate tests for infective endocarditis at an academic medical center
Amuchastegui T, Hur DJ, Fillipon N, Eder MD, Bonomo JA, Kim Y, McNamara RL, Malinis M, Sugeng L. An assessment of transesophageal echocardiography studies rated as rarely appropriate tests for infective endocarditis at an academic medical center. Echocardiography 2019, 36: 2070-2077. PMID: 31705577, DOI: 10.1111/echo.14525.Peer-Reviewed Original ResearchConceptsAppropriate use criteriaTransesophageal echocardiographyAcademic medical centerInfective endocarditisMedical CenterTertiary academic medical centerComplex infectious processTransesophageal echocardiography studyRetrospective chart reviewInfectious disease specialistsElectronic medical chartsTEE findingsChart reviewRetrospective cohortDuke criteriaMedical chartsDisease specialistsEchocardiography studyRetrospective studyPhysical examinationEndocardial involvementID specialistsBlood culturesInfectious processTEE use
2024
Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis
Hassab A, Hur D, Vallabhajosyula P, Tellides G, Assi R. Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis. JCI Insight 2024, 9: e172437. PMID: 38592807, PMCID: PMC11141924, DOI: 10.1172/jci.insight.172437.Peer-Reviewed Original ResearchConceptsDepartment of SurgerySmooth muscle cellsCellular response to injuryResponse to injuryImmunofluorescence confocal microscopyVessel wall repairPrimary lesionAscending aortaConduit functionAneurysmal diseaseDense fibrosisRadiological signsMural hematomaTear progressionMuscle cellsNon-hemorrhagicErythrocyte extravasationWall repairAortaTear completionInduce atherosclerosisHealed lesionsScattered leukocytesMinimal injuryConclusionThese findingsFactors associated with reporting left ventricular ejection fraction with 3D echocardiography in real‐world practice
Faridi K, Zhu Z, Shah N, Crandall I, McNamara R, Flueckiger P, Bachand K, Lombo B, Hur D, Agarwal V, Reinhardt S, Velazquez E, Sugeng L. Factors associated with reporting left ventricular ejection fraction with 3D echocardiography in real‐world practice. Echocardiography 2024, 41: e15774. PMID: 38329886, DOI: 10.1111/echo.15774.Peer-Reviewed Original ResearchConceptsTransthoracic echocardiogramVentricular ejection fractionOutpatient transthoracic echocardiogramsReal-world practiceEjection fractionLeft ventricular ejection fractionAssess left ventricular ejection fractionInpatient transthoracic echocardiogramsMultivariate logistic regressionLVEFHospitalized patientsMedical CenterSonographersClinical settingLogistic regressionUltrasound machineChemotherapyContrast enhancement agentsPortable studiesNegative association
2022
Growth rate of ascending thoracic aortic aneurysms in a non-referral-based population
Weininger G, Mori M, Yousef S, Hur DJ, Assi R, Geirsson A, Vallabhajosyula P. Growth rate of ascending thoracic aortic aneurysms in a non-referral-based population. Journal Of Cardiothoracic Surgery 2022, 17: 14. PMID: 35109884, PMCID: PMC8812194, DOI: 10.1186/s13019-022-01761-6.Peer-Reviewed Original ResearchConceptsAneurysm growth rateAortic dilatationAortic aneurysmStudy populationCT scanInitial aneurysm sizeTrue natural historyPatients age 50High-risk patientsMedian time intervalLarge institutional databaseThoracic aortic aneurysmComputed tomography scanAortic aneurysm diseaseRisk patientsAortic sizeInstitutional databaseTomography scanAneurysm diseaseRadiologic diagnosisAneurysm sizeBackgroundPrior studiesAge 50PatientsNatural history
2020
Left Ventricular Systolic Function and Inpatient Mortality in Patients Hospitalized with Coronavirus Disease 2019 (COVID-19)
Faridi KF, Hennessey KC, Shah N, Soufer A, Wang Y, Sugeng L, Agarwal V, Sharma R, Sewanan LR, Hur DJ, Velazquez EJ, McNamara RL. Left Ventricular Systolic Function and Inpatient Mortality in Patients Hospitalized with Coronavirus Disease 2019 (COVID-19). Journal Of The American Society Of Echocardiography 2020, 33: 1414-1415. PMID: 32951969, PMCID: PMC7442910, DOI: 10.1016/j.echo.2020.08.016.Peer-Reviewed Original ResearchInpatient Transthoracic Echocardiography during the COVID-19 Pandemic: Evaluating a New Triage Process
Hennessey KC, Shah N, Soufer A, Wang Y, Agarwal V, McNamara RL, Crandall I, Balan S, Pereira J, Kim Y, Hur DJ, Velazquez EJ, Sugeng L, Faridi KF. Inpatient Transthoracic Echocardiography during the COVID-19 Pandemic: Evaluating a New Triage Process. Journal Of The American Society Of Echocardiography 2020, 33: 1418-1419. PMID: 32888760, PMCID: PMC7392041, DOI: 10.1016/j.echo.2020.07.018.Peer-Reviewed Original Research
2019
The feasibility of contrast echocardiography in the assessment of right ventricular size and function
Pereira JB, Essa M, Ugonabo I, Hur DJ, Crandall I, Vaccarelli M, Sugeng L. The feasibility of contrast echocardiography in the assessment of right ventricular size and function. Echocardiography 2019, 36: 1979-1988. PMID: 31633241, DOI: 10.1111/echo.14504.Peer-Reviewed Original ResearchConceptsRight ventricular evaluationRight ventricular sizeSegmental wall motionRight ventricular imagingRV-focused viewWall motionRight ventricle evaluationContrast enhancementWilcoxon signed-rank testInter-observer agreementRV dimensionsEchocardiography studyIntra-observer reproducibilityVentricular sizeSigned-rank testContrast echocardiographyRV imagingAnatomical assessmentVentricular imagingPatientsPercent agreementIrregular rhythmTotal segmentsIndependent observersSample t-testLeft atrial fibrosis correlates with extent of left ventricular myocardial delayed enhancement and left ventricular strain in hypertrophic cardiomyopathy
Latif SR, Nguyen VQ, Peters DC, Soufer A, Henry ML, Grunseich K, Testani J, Hur DJ, Huber S, Mojibian H, Dicks D, Sinusas AJ, Meadows JL, Papoutsidakis N, Jacoby D, Baldassarre LA. Left atrial fibrosis correlates with extent of left ventricular myocardial delayed enhancement and left ventricular strain in hypertrophic cardiomyopathy. The International Journal Of Cardiovascular Imaging 2019, 35: 1309-1318. PMID: 30790116, DOI: 10.1007/s10554-019-01551-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsAtrial Function, LeftAtrial RemodelingCardiomyopathy, HypertrophicContrast MediaFemaleFibrosisHeart AtriaHeart VentriclesHumansHypertrophy, Left VentricularMagnetic Resonance Imaging, CineMaleMiddle AgedOrganometallic CompoundsPredictive Value of TestsRetrospective StudiesVentricular Dysfunction, LeftVentricular Function, LeftVentricular RemodelingConceptsLA fibrosisLV-LGEHypertrophic cardiomyopathyLA-LGELV fibrosisLV parametersLV end-diastolic volumeSetting of HCMAldosterone system inhibitionLate gadolinium enhancement (LGE) sequencesLV global strainLeft ventricular massEnd-diastolic volumeLeft atrial fibrosisMaximum wall thicknessFibrosis correlatesRenin-AngiotensinVentricular strainMedication usageAtrial fibrosisLV remodelingVentricular massLV massSystem inhibitionDiastolic volume
2010
The Snow-Shoveler's ST Elevation Myocardial Infarction
Janardhanan R, Henry Z, Hur DJ, Lin CM, Lopez D, Reagan PM, Rudnick SR, Koshko TJ, Keeley EC. The Snow-Shoveler's ST Elevation Myocardial Infarction. The American Journal Of Cardiology 2010, 106: 596-600. PMID: 20691323, PMCID: PMC2958046, DOI: 10.1016/j.amjcard.2010.03.075.Peer-Reviewed Original ResearchConceptsST-elevation myocardial infarctionElevation myocardial infarctionCardiac risk factorsCoronary artery diseaseMyocardial infarctionStent thrombosesArtery diseaseRisk factorsTraditional cardiac risk factorsPrevious coronary arteryAdverse cardiovascular eventsCoronary stent placementCardiac catheterization laboratorySnow shovelingCardiovascular eventsMost patientsCoronary angiographyCase seriesStent thrombosisCoronary arteryStent placementCatheterization laboratoryTobacco useSedentary lifestyleInfarction
2006
Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking
Boyadjiev SA, Fromme JC, Ben J, Chong SS, Nauta C, Hur DJ, Zhang G, Hamamoto S, Schekman R, Ravazzola M, Orci L, Eyaid W. Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking. Nature Genetics 2006, 38: 1192-1197. PMID: 16980979, DOI: 10.1038/ng1876.Peer-Reviewed Original ResearchConceptsSutural dysplasiaSecretory proteinsEndoplasmic reticulumPositional cloning approachEndoplasmic reticulum exportCell-free vesiclesAmino acid substitutionsGolgi traffickingZebrafish embryosCloning approachGolgi complexCytoplasmic mislocalizationAcid substitutionsSkeletal defectsProteinReticulumVesiclesSutural cataractEssential componentFacial dysmorphismAutosomal recessive syndromeCOPIISEC23AMorpholinoSec31