1993
Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells.
Wucherpfennig KW, Liao YJ, Prendergast M, Prendergast J, Hafler DA, Strominger JL. Human fetal liver gamma/delta T cells predominantly use unusual rearrangements of the T cell receptor delta and gamma loci expressed on both CD4+CD8- and CD4-CD8- gamma/delta T cells. Journal Of Experimental Medicine 1993, 177: 425-432. PMID: 8093893, PMCID: PMC2190895, DOI: 10.1084/jem.177.2.425.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceCD4-Positive T-LymphocytesClone CellsGene Rearrangement, delta-Chain T-Cell Antigen ReceptorGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorHumansLiverMolecular Sequence DataOligodeoxyribonucleotidesReceptors, Antigen, T-Cell, gamma-deltaT-Lymphocyte SubsetsConceptsGamma/delta T cellsGamma/delta T cell clonesDelta T cellsT cell clonesGamma/delta T cell populationsT cell populationsT cellsFetal liverT cell developmentCell clonesCD4-CD8TCR delta chain transcriptsUnusual T-cell populationCell populationsFetal immune systemDelta-chain transcriptsGene rearrangementsT-cell receptor gammaGamma chain rearrangementT-cell receptor deltaHuman fetal liverTCR delta chainCell developmentAlpha/betaFetal thymus
1992
T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions.
Wucherpfennig KW, Newcombe J, Li H, Keddy C, Cuzner ML, Hafler DA. T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions. Journal Of Experimental Medicine 1992, 175: 993-1002. PMID: 1348083, PMCID: PMC2119186, DOI: 10.1084/jem.175.4.993.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAntigens, Differentiation, T-LymphocyteBase SequenceCD2 AntigensChronic DiseaseClone CellsCytokinesGene ExpressionHumansInterleukin-1Interleukin-2Interleukin-4Molecular Sequence DataMultiple SclerosisOligodeoxyribonucleotidesPolymerase Chain ReactionReceptors, Antigen, T-Cell, alpha-betaReceptors, ImmunologicRNA, MessengerConceptsTCR V alphaTCR repertoireBeta repertoireMultiple sclerosisV alphaActive lesionsMS plaquesT cellsAlpha/beta T cellsActive multiple sclerosis lesionsMS plaque tissueCentral nervous system tissueT cell recruitmentBeta T cellsActive MS plaquesChronic inflammatory diseaseIL-4 mRNAT cell expansionIL-1 mRNATCR V gene segmentsCentral nervous systemCases of subacuteNervous system tissueSites of inflammationTCR V genes