2006
Innate Immunity in Multiple Sclerosis: Myeloid Dendritic Cells in Secondary Progressive Multiple Sclerosis Are Activated and Drive a Proinflammatory Immune Response
Karni A, Abraham M, Monsonego A, Cai G, Freeman GJ, Hafler D, Khoury SJ, Weiner HL. Innate Immunity in Multiple Sclerosis: Myeloid Dendritic Cells in Secondary Progressive Multiple Sclerosis Are Activated and Drive a Proinflammatory Immune Response. The Journal Of Immunology 2006, 177: 4196-4202. PMID: 16951385, DOI: 10.4049/jimmunol.177.6.4196.Peer-Reviewed Original ResearchConceptsMyeloid dendritic cellsDendritic cellsMultiple sclerosisInnate immune systemRR-MSImmune responseImmune systemT cell-mediated autoimmune diseaseSecondary progressive multiple sclerosisCell-mediated autoimmune diseaseStages of MSIncreased percentageProgressive phaseNeuronal degenerative changesSecondary progressive phaseSP-MS patientsProgressive multiple sclerosisProinflammatory immune responsePrimary immune responseNaive T cellsImmunologic basisTh1 responseClinical patternMS patientsPD-L1
1991
Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis
Hafler D, Orav J, Gertz R, Stazzone L, Weiner H. Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis. Journal Of Neuroimmunology 1991, 32: 149-158. PMID: 1672870, DOI: 10.1016/0165-5728(91)90007-t.Peer-Reviewed Original ResearchConceptsT cell populationsDisability Status ScaleMixed lymphocyte reactionSpontaneous proliferationT cellsImmune measuresACTH infusionImmune functionChronic progressive multiple sclerosisProgressive multiple sclerosis patientsCD4/CD8 ratioCell populationsAllogeneic mixed lymphocyte reactionFunctional immune measuresPeripheral blood CD4Progressive multiple sclerosisPositive clinical responsePositive T cellsMultiple sclerosis patientsFunctional immune assaysLevels of proliferationBlood CD4CD8 ratioClinical improvementClinical response
1984
T Cell Subsets in Patients with Multiple Sclerosis: An Overviewa
WEINER H, HAFLER D, FALLIS R, JOHNSON D, AULT K, HAUSER S. T Cell Subsets in Patients with Multiple Sclerosis: An Overviewa. Annals Of The New York Academy Of Sciences 1984, 436: 281-290. PMID: 6152384, DOI: 10.1111/j.1749-6632.1984.tb14800.x.Peer-Reviewed Original ResearchAltered blood T-cell subsets in patients with multiple sclerosis
Weiner H, Hafler D, Fallis R, Johnson D, Ault K, Hauser S. Altered blood T-cell subsets in patients with multiple sclerosis. Journal Of Neuroimmunology 1984, 6: 115-121. PMID: 6373819, DOI: 10.1016/0165-5728(84)90032-8.Peer-Reviewed Original ResearchConceptsT cell subsetsMultiple sclerosisBlood T cell subsetsChronic progressive patientsActive multiple sclerosisStage of illnessSpontaneous immunoglobulin productionCentral nervous systemImmunoregulatory abnormalitiesT8 ratioActive diseaseDisease activityProgressive patientsAcute patientsPeripheral bloodImmunoglobulin productionImmune functionPatientsNervous systemSclerosisSpinal fluidDiagnostic testsAbnormalitiesVariety of protocolsPleocytosis