2022
Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells
Sumida TS, Dulberg S, Schupp JC, Lincoln MR, Stillwell HA, Axisa PP, Comi M, Unterman A, Kaminski N, Madi A, Kuchroo VK, Hafler DA. Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells. Nature Immunology 2022, 23: 632-642. PMID: 35301508, PMCID: PMC8989655, DOI: 10.1038/s41590-022-01152-y.Peer-Reviewed Original ResearchMeSH KeywordsCOVID-19Gene Regulatory NetworksHumansInterferon Type IReceptors, Antigen, T-CellReceptors, ImmunologicSARS-CoV-2T-LymphocytesConceptsCoinhibitory receptor expressionHuman T cellsIFN-I responsesCoinhibitory receptorsT cellsTIGIT expressionReceptor expressionAcute SARS-CoV-2 infectionPD-1/TimSARS-CoV-2 infectionEnhancement of immunotherapyType 1 interferonT-cell featuresLAG-3Infectious diseasesDifferent temporal kineticsTranscription factorsCancer therapyReceptorsCell featuresKey transcription factorIFNPresent studyMRNA profilingKey regulator
1999
HTLV-I-Infected T Cells Evade the Antiproliferative Action of IFN-β
Smith D, Buckle G, Hafler D, Frank D, Höllsberg P. HTLV-I-Infected T Cells Evade the Antiproliferative Action of IFN-β. Virology 1999, 257: 314-321. PMID: 10329542, DOI: 10.1006/viro.1999.9679.Peer-Reviewed Original ResearchConceptsT cell clonesIFN-betaT cellsAntiproliferative actionHuman T-cell lymphotropic virus type IMyelopathy/tropical spastic paraparesisLymphotropic virus type INormal immunoregulatory mechanismsInnate immune defense mechanismsHost T cellsExogenous IL-2Tropical spastic paraparesisT cell proliferationImmune defense mechanismsVirus type IT cell activationPathogenesis of HTLVImmunoregulatory mechanismsSpastic paraparesisIL-2Phosphorylation of STAT1IFN-gammaViral infectionHigh dosesHTLV