2011
Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin
Obermeier B, Lovato L, Mentele R, Brück W, Forne I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O'Connor KC, Dornmair K. Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. Journal Of Neuroimmunology 2011, 233: 245-248. PMID: 21353315, PMCID: PMC3090654, DOI: 10.1016/j.jneuroim.2011.01.010.Peer-Reviewed Original Research
2001
Immunological Memory: Contribution of Memory B Cells Expressing Costimulatory Molecules in the Resting State
Bar-Or A, Oliveira E, Anderson D, Krieger J, Duddy M, O’Connor K, Hafler D. Immunological Memory: Contribution of Memory B Cells Expressing Costimulatory Molecules in the Resting State. The Journal Of Immunology 2001, 167: 5669-5677. PMID: 11698439, DOI: 10.4049/jimmunol.167.10.5669.Peer-Reviewed Original ResearchConceptsMemory B cellsB cell subsetsB cellsCell subsetsCostimulatory moleculesB cell memory compartmentMemory responsesImmune memory responseDistinct B cell subsetsHuman memory B cellsHumoral memory responsesHuman B cellsTh cellsImmunological memoryT cellsMemory compartmentPoor APCsMurine systemNovel subpopulationRelative paucityCells
1986
Antigen reactive memory T cells are defined by Ta1.
Hafler DA, Fox DA, Benjamin D, Weiner HL. Antigen reactive memory T cells are defined by Ta1. The Journal Of Immunology 1986, 137: 414-8. PMID: 3013990, DOI: 10.4049/jimmunol.137.2.414.Peer-Reviewed Original ResearchConceptsT cellsReactive memory T cellsPeripheral blood T cellsAutologous mixed lymphocyte responseHuman peripheral blood T cellsMemory T cellsMixed lymphocyte responseBlood T cellsPresence of PWMT cell clonesEnhanced proliferative responseTA1 cellsActivated T cellsNormal human subjectsT cell linesT memory cellsSuppressor cellsLymphocyte responsesAnamnestic responseMitogen PHAPeripheral bloodLymphocyte populationsIL-2Tetanus toxoidT lymphocytesImmunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12.
Hafler D, Fallis R, Dawson D, Schlossman S, Reinherz E, Weiner H. Immunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12. Neurology 1986, 36: 777-84. PMID: 3486383, DOI: 10.1212/wnl.36.6.777.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntibodies, MonoclonalHumansImmunoglobulinsMiddle AgedMultiple SclerosisT-LymphocytesConceptsHuman anti-mouse antibodiesAnti-mouse antibodiesDay 3Anti-T cell monoclonal antibodiesProgressive multiple sclerosis patientsPost-thymic T cellsMultiple sclerosis patientsMild allergic reactionsProgression of diseaseMonoclonal Antibodies ReactiveEffect of treatmentPhase one studyProgressive MSClinical effectsSclerosis patientsImmunologic responseBlood levelsImmunologic studiesPokeweed mitogenAllergic reactionsT cellsAntibody reactivePatientsDay 1Day 7
1984
Altered blood T-cell subsets in patients with multiple sclerosis
Weiner H, Hafler D, Fallis R, Johnson D, Ault K, Hauser S. Altered blood T-cell subsets in patients with multiple sclerosis. Journal Of Neuroimmunology 1984, 6: 115-121. PMID: 6373819, DOI: 10.1016/0165-5728(84)90032-8.Peer-Reviewed Original ResearchConceptsT cell subsetsMultiple sclerosisBlood T cell subsetsChronic progressive patientsActive multiple sclerosisStage of illnessSpontaneous immunoglobulin productionCentral nervous systemImmunoregulatory abnormalitiesT8 ratioActive diseaseDisease activityProgressive patientsAcute patientsPeripheral bloodImmunoglobulin productionImmune functionPatientsNervous systemSclerosisSpinal fluidDiagnostic testsAbnormalitiesVariety of protocolsPleocytosis