2016
Power estimation for non-standardized multisite studies
Keshavan A, Paul F, Beyer MK, Zhu AH, Papinutto N, Shinohara RT, Stern W, Amann M, Bakshi R, Bischof A, Carriero A, Comabella M, Crane JC, D'Alfonso S, Demaerel P, Dubois B, Filippi M, Fleischer V, Fontaine B, Gaetano L, Goris A, Graetz C, Gröger A, Groppa S, Hafler DA, Harbo HF, Hemmer B, Jordan K, Kappos L, Kirkish G, Llufriu S, Magon S, Martinelli-Boneschi F, McCauley JL, Montalban X, Mühlau M, Pelletier D, Pattany PM, Pericak-Vance M, Cournu-Rebeix I, Rocca MA, Rovira A, Schlaeger R, Saiz A, Sprenger T, Stecco A, Uitdehaag BMJ, Villoslada P, Wattjes MP, Weiner H, Wuerfel J, Zimmer C, Zipp F, Consortium I, Hauser SL, Oksenberg JR, Henry RG. Power estimation for non-standardized multisite studies. NeuroImage 2016, 134: 281-294. PMID: 27039700, PMCID: PMC5656257, DOI: 10.1016/j.neuroimage.2016.03.051.Peer-Reviewed Original Research
2011
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
, , Sawcer S, Hellenthal G, Pirinen M, Spencer C, Patsopoulos N, Moutsianas L, Dilthey A, Su Z, Freeman C, Hunt S, Edkins S, Gray E, Booth D, Potter S, Goris A, Band G, Oturai A, Strange A, Saarela J, Bellenguez C, Fontaine B, Gillman M, Hemmer B, Gwilliam R, Zipp F, Jayakumar A, Martin R, Leslie S, Hawkins S, Giannoulatou E, D’alfonso S, Blackburn H, Boneschi F, Liddle J, Harbo H, Perez M, Spurkland A, Waller M, Mycko M, Ricketts M, Comabella M, Hammond N, Kockum I, McCann O, Ban M, Whittaker P, Kemppinen A, Weston P, Hawkins C, Widaa S, Zajicek J, Dronov S, Robertson N, Bumpstead S, Barcellos L, Ravindrarajah R, Abraham R, Alfredsson L, Ardlie K, Aubin C, Baker A, Baker K, Baranzini S, Bergamaschi L, Bergamaschi R, Bernstein A, Berthele A, Boggild M, Bradfield J, Brassat D, Broadley S, Buck D, Butzkueven H, Capra R, Carroll W, Cavalla P, Celius E, Cepok S, Chiavacci R, Clerget-Darpoux F, Clysters K, Comi G, Cossburn M, Cournu-Rebeix I, Cox M, Cozen W, Cree B, Cross A, Cusi D, Daly M, Davis E, de Bakker P, Debouverie M, D’hooghe M, Dixon K, Dobosi R, Dubois B, Ellinghaus D, Elovaara I, Esposito F, Fontenille C, Foote S, Franke A, Galimberti D, Ghezzi A, Glessner J, Gomez R, Gout O, Graham C, Grant S, Guerini F, Hakonarson H, Hall P, Hamsten A, Hartung H, Heard R, Heath S, Hobart J, Hoshi M, Infante-Duarte C, Ingram G, Ingram W, Islam T, Jagodic M, Kabesch M, Kermode A, Kilpatrick T, Kim C, Klopp N, Koivisto K, Larsson M, Lathrop M, Lechner-Scott J, Leone M, Leppä V, Liljedahl U, Bomfim I, Lincoln R, Link J, Liu J, Lorentzen Å, Lupoli S, Macciardi F, Mack T, Marriott M, Martinelli V, Mason D, McCauley J, Mentch F, Mero I, Mihalova T, Montalban X, Mottershead J, Myhr K, Naldi P, Ollier W, Page A, Palotie A, Pelletier J, Piccio L, Pickersgill T, Piehl F, Pobywajlo S, Quach H, Ramsay P, Reunanen M, Reynolds R, Rioux J, Rodegher M, Roesner S, Rubio J, Rückert I, Salvetti M, Salvi E, Santaniello A, Schaefer C, Schreiber S, Schulze C, Scott R, Sellebjerg F, Selmaj K, Sexton D, Shen L, Simms-Acuna B, Skidmore S, Sleiman P, Smestad C, Sørensen P, Søndergaard H, Stankovich J, Strange R, Sulonen A, Sundqvist E, Syvänen A, Taddeo F, Taylor B, Blackwell J, Tienari P, Bramon E, Tourbah A, Brown M, Tronczynska E, Casas J, Tubridy N, Corvin A, Vickery J, Jankowski J, Villoslada P, Markus H, Wang K, Mathew C, Wason J, Palmer C, Wichmann H, Plomin R, Willoughby E, Rautanen A, Winkelmann J, Wittig M, Trembath R, Yaouanq J, Viswanathan A, Zhang H, Wood N, Zuvich R, Deloukas P, Langford C, Duncanson A, Oksenberg J, Pericak-Vance M, Haines J, Olsson T, Hillert J, Ivinson A, De Jager P, Peltonen L, Stewart G, Hafler D, Hauser S, McVean G, Donnelly P, Compston A. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011, 476: 214-219. PMID: 21833088, PMCID: PMC3182531, DOI: 10.1038/nature10251.Peer-Reviewed Original ResearchMeSH KeywordsAllelesCell DifferentiationEuropeGenetic Predisposition to DiseaseGenome-Wide Association StudyGenome, HumanHLA-A AntigensHLA-DR AntigensHLA-DRB1 ChainsHumansImmunity, CellularMajor Histocompatibility ComplexMultiple SclerosisPolymorphism, Single NucleotideSample SizeT-Lymphocytes, Helper-InducerConceptsCollaborative genome-wide association studiesGenome-wide association studiesNovel susceptibility lociRegions of DNAGenetic architectureAssociation studiesSusceptibility lociDifferentiation of T helper cellsGenetic riskEuropean descentCell-mediated immune mechanismsT helper cellsCentral nervous systemImmune mechanismsLociIntensive studyDNAMultiple sclerosisNervous systemGeneticsNeurodegenerationDiseaseSclerosisDifferentiationCells
2010
Functionally defective germline variants of sialic acid acetylesterase in autoimmunity
Surolia I, Pirnie SP, Chellappa V, Taylor KN, Cariappa A, Moya J, Liu H, Bell DW, Driscoll DR, Diederichs S, Haider K, Netravali I, Le S, Elia R, Dow E, Lee A, Freudenberg J, De Jager PL, Chretien Y, Varki A, MacDonald ME, Gillis T, Behrens TW, Bloch D, Collier D, Korzenik J, Podolsky DK, Hafler D, Murali M, Sands B, Stone JH, Gregersen PK, Pillai S. Functionally defective germline variants of sialic acid acetylesterase in autoimmunity. Nature 2010, 466: 243-247. PMID: 20555325, PMCID: PMC2900412, DOI: 10.1038/nature09115.Peer-Reviewed Original ResearchMeSH KeywordsAcetylationAcetylesteraseAllelesAnimalsAntibodies, AntinuclearArthritis, RheumatoidAutoimmune DiseasesAutoimmunityBiocatalysisB-LymphocytesCarboxylic Ester HydrolasesCase-Control StudiesCell LineDiabetes Mellitus, Type 1EuropeExonsGenetic Predisposition to DiseaseGerm-Line MutationHumansMiceN-Acetylneuraminic AcidOdds RatioPolymorphism, Single NucleotideSample SizeSequence Analysis, DNA
2005
A High-Density Screen for Linkage in Multiple Sclerosis
Sawcer S, Ban M, Maranian M, Yeo TW, Compston A, Kirby A, Daly MJ, De Jager PL, Walsh E, Lander ES, Rioux JD, Hafler DA, Ivinson A, Rimmler J, Gregory SG, Schmidt S, Pericak-Vance MA, Akesson E, Hillert J, Datta P, Oturai A, Ryder LP, Harbo HF, Spurkland A, Myhr KM, Laaksonen M, Booth D, Heard R, Stewart G, Lincoln R, Barcellos LF, Hauser SL, Oksenberg JR, Kenealy SJ, Haines JL. A High-Density Screen for Linkage in Multiple Sclerosis. American Journal Of Human Genetics 2005, 77: 454-467. PMID: 16080120, PMCID: PMC1226210, DOI: 10.1086/444547.Peer-Reviewed Original Research
2004
Re: GAMES issue study: Are international genetic consortia functional?
De Jager PL, Walsh EC, Rioux JD, Hafler DA. Re: GAMES issue study: Are international genetic consortia functional? Journal Of Neuroimmunology 2004, 153: 5-6. PMID: 15334748.Peer-Reviewed Original Research