Pathology of an Islet Transplant 2 Years After Transplantation: Evidence for a Nonimmunological Loss
Smith RN, Kent SC, Nagle J, Selig M, Iafrate AJ, Najafian N, Hafler DA, Auchincloss H, Orban T, Cagliero E. Pathology of an Islet Transplant 2 Years After Transplantation: Evidence for a Nonimmunological Loss. Transplantation 2008, 86: 54-62. PMID: 18622278, DOI: 10.1097/tp.0b013e318173a5da.Peer-Reviewed Original ResearchConceptsAllogeneic sensitizationIslet transplantsELISPOT assayRecurrent diabetic nephropathyEvidence of rejectionC-peptide secretionCause of deathNative pancreatic isletsHypertensive strokeIntrahepatic isletsDiabetic nephropathyInsulin independenceAllogeneic isletsAtrophic pancreasPathological findingsImmunological basisEdmonton protocolPortal veinComplete autopsyIslet transplantationImmunohistochemical analysisPortal venulesDrug toxicityEarly changesPhysiological abnormalities