2013
Protein array–based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis
Querol L, Clark PL, Bailey MA, Cotsapas C, Cross AH, Hafler DA, Kleinstein SH, Lee JY, Yaari G, Willis SN, O'Connor KC. Protein array–based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis. Neurology 2013, 81: 956-963. PMID: 23921886, PMCID: PMC3888197, DOI: 10.1212/wnl.0b013e3182a43b48.Peer-Reviewed Original ResearchConceptsCSF of patientsMultiple sclerosisNeurologic diseaseEpstein-Barr virus infectionImmunoglobulin GElevated immunoglobulin GInflammatory neurologic diseasesSubset of patientsLarger validation cohortRecombination signal binding proteinImmunoglobulin kappa J regionCSF autoantibodiesValidation cohortControl subjectsSerum reactivityAutoantigen candidatesHigh prevalenceVirus infectionPatientsAutoantibodiesCSFSclerosisArray-based profilingDiseaseELISA
1985
In Vivo Activated T Lymphocytes in the Peripheral Blood and Cerebrospinal Fluid of Patients with Multiple Sclerosis
Hafler D, Fox D, Manning M, Schlossman S, Reinherz E, Weiner H. In Vivo Activated T Lymphocytes in the Peripheral Blood and Cerebrospinal Fluid of Patients with Multiple Sclerosis. New England Journal Of Medicine 1985, 312: 1405-1411. PMID: 2985995, DOI: 10.1056/nejm198505303122201.Peer-Reviewed Original ResearchConceptsProgressive multiple sclerosisMultiple sclerosisInterleukin-2 receptorNervous system diseasesNeurologic diseaseSpinal fluidPeripheral bloodSystem diseasesCerebrospinal fluidInflammatory central nervous system diseasesCentral nervous system diseaseSystemic immune activationInflammatory neurologic diseasesPeripheral blood lymphocytesBlood of patientsActivated T lymphocytesAbnormal immunologic activityCent of lymphocytesCent of cellsT cell activationImmune activationT cellsT lymphocytesImmunologic activityNormal controls