2009
Engineered Interleukin-2 Antagonists for the Inhibition of Regulatory T Cells
Liu DV, Maier LM, Hafler DA, Wittrup KD. Engineered Interleukin-2 Antagonists for the Inhibition of Regulatory T Cells. Journal Of Immunotherapy 2009, 32: 887-894. PMID: 19816193, PMCID: PMC4078882, DOI: 10.1097/cji.0b013e3181b528da.Peer-Reviewed Original ResearchConceptsIL-2 receptorRegulatory T cellsWild-type IL-2IL-2T cellsIL-2 analogHigh regulatory T cellsIL-2 receptor alphaRegulatory T-cell suppressionInterleukin-2 antagonistsAntitumor immune responseT cell suppressionIL-2 receptor alpha subunitT cell growthT cell linesTreg inhibitionImmunosuppressive effectsCancer patientsSimilar efficacyImmune responseReceptor alpha subunitCell suppressionReceptor alphaAlpha subunitHuman interleukin
1988
Anti‐CD4 and Anti‐CD2 Monoclonal Antibody Infusions in Subjects with Multiple Sclerosis Immunosuppressive Effects and Human Antimouse Responses
HAFLER D, WEINER H. Anti‐CD4 and Anti‐CD2 Monoclonal Antibody Infusions in Subjects with Multiple Sclerosis Immunosuppressive Effects and Human Antimouse Responses. Annals Of The New York Academy Of Sciences 1988, 540: 557-559. PMID: 2905125, DOI: 10.1111/j.1749-6632.1988.tb27171.x.Peer-Reviewed Original ResearchAnti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses.
Hafler DA, Ritz J, Schlossman SF, Weiner HL. Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses. The Journal Of Immunology 1988, 141: 131-8. PMID: 2454256, DOI: 10.4049/jimmunol.141.1.131.Peer-Reviewed Original ResearchConceptsHuman anti-mouse antibodiesAnti-mouse responseAnti-mouse antibodiesHuman anti-mouse responseMultiple sclerosisChronic progressive multiple sclerosisPhase I clinical studyAnti-CD2 monoclonal antibodiesProgressive multiple sclerosisMore chronic diseasesT cell subpopulationsHuman immune responseT cell activationAcute immunosuppressionMAb infusionsT cell surfaceAnti-CD4Daily infusionsImmunologic responseImmunosuppressive effectsChronic diseasesIgG isotypeClinical studiesImmune responseLike antibodies
1987
Anti-CD4 and anti-CD2 monoclonal antibodies infusions in multiple sclerosis: Immunosuppressive effects and human anti-mouse responses
Weiner H, Simon L, Hafler D. Anti-CD4 and anti-CD2 monoclonal antibodies infusions in multiple sclerosis: Immunosuppressive effects and human anti-mouse responses. Journal Of Neuroimmunology 1987, 16: 180. DOI: 10.1016/0165-5728(87)90410-3.Peer-Reviewed Original Research