2003
CD4+CD25+ Regulatory Cells from Human Peripheral Blood Express Very High Levels of CD25 Ex Vivo
Baecher‐Allan C, Brown JA, Freeman GJ, Hafler DA. CD4+CD25+ Regulatory Cells from Human Peripheral Blood Express Very High Levels of CD25 Ex Vivo. Novartis Foundation Symposia 2003, 252: 67-91. PMID: 14609213, DOI: 10.1002/0470871628.ch6.Peer-Reviewed Original ResearchConceptsT cellsRegulatory cellsPD-1/PD-L1 interactionLigand PD-L1Responder T cellsPD-L1 interactionContact-dependent mannerCo-culture assaysCTLA4 blockadeRegulatory populationPD-1PD-L1HLA-DRMultiple surface antigensCytokine secretionCD45RA expressionSurface antigenEx vivoLevel of expressionModest inductionSuppressive characteristicsFunctional activityHigh levelsCD25CD45RO
1991
The coexpression of CD45RA and CD45RO isoforms on T cells during the S/G2/M stages of cell cycle
LaSalle J, Hafler D. The coexpression of CD45RA and CD45RO isoforms on T cells during the S/G2/M stages of cell cycle. Cellular Immunology 1991, 138: 197-206. PMID: 1833074, DOI: 10.1016/0008-8749(91)90144-z.Peer-Reviewed Original ResearchConceptsT cell clonesCell cycleT cellsCD45RA expressionCord bloodTyrosine phosphatase CD45Cell clonesM stageCell cycle stagePHA activationPeripheral blood T cellsCD45RO T cellsCoexpression of CD45RAG2/M stageCD45RA T cellsT cell populationsBlood T cellsG2/M phaseNaive T cellsPhosphatase CD45Propidium iodide stainingHematopoietic cellsM phaseCD45RACD45RO isoform