1993
Suppression of Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens
Weiner H, Miller A, Khoury S, Zhang Z, Al-Sabbagh A, Brod S, Lider O, Higgins P, Sobel R, Matsui M, Sayegh M, Carpenter C, Eisenbarth G, Nussenblatt R, Hafler D. Suppression of Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens. 1993, 627-634. DOI: 10.1007/978-3-642-51479-1_81.Peer-Reviewed Original ResearchSuppressor T cellsAutoimmune diseasesOral administrationPeyer's patchesT cellsEpithelial cellsImmune systemAntigen-specific suppressor T cellsOrgan-specific autoimmune diseasesHuman gut epithelial cellsAutoreactive immune processesSpecific suppressor cellsPeripheral immune toleranceAntigen-presenting cellsClass II antigensAnti-idiotypic antibodiesAntigen-induced toleranceIntestinal epithelial cellsGut epithelial cellsHen's egg proteinsAutoimmune processOral toleranceSuppressor cellsImmune toleranceImmunologic tolerance
1988
Immunosuppression with monoclonal antibodies in multiple sclerosis.
Hafler DA, Weiner HL. Immunosuppression with monoclonal antibodies in multiple sclerosis. Neurology 1988, 38: 42-7. PMID: 3260356.Peer-Reviewed Original ResearchConceptsHuman anti-mouse antibodiesChronic progressive multiple sclerosisAnti-T cell mAbsAnti-mouse antibodiesProgressive multiple sclerosisMAb infusionsMultiple sclerosisChronic diseasesT11 mAbPhase I clinical studyAnti-idiotypic activityMonoclonal antibody infusionMore chronic diseasesT cell subpopulationsAnti-mouse responseHuman immune responseAnti-idiotypic antibodiesHuman anti-mouse responseT cell activationAcute immunosuppressionT cell surfaceAntibody infusionImmunologic responseRepeated administrationIgG isotype