Immunosuppression with monoclonal antibodies in multiple sclerosis.
Hafler DA, Weiner HL. Immunosuppression with monoclonal antibodies in multiple sclerosis. Neurology 1988, 38: 42-7. PMID: 3260356.Peer-Reviewed Original ResearchConceptsHuman anti-mouse antibodiesChronic progressive multiple sclerosisAnti-T cell mAbsAnti-mouse antibodiesProgressive multiple sclerosisMAb infusionsMultiple sclerosisChronic diseasesT11 mAbPhase I clinical studyAnti-idiotypic activityMonoclonal antibody infusionMore chronic diseasesT cell subpopulationsAnti-mouse responseHuman immune responseAnti-idiotypic antibodiesHuman anti-mouse responseT cell activationAcute immunosuppressionT cell surfaceAntibody infusionImmunologic responseRepeated administrationIgG isotype