1988
Immunotherapy of multiple sclerosis
Weiner H, Hafler D. Immunotherapy of multiple sclerosis. Annals Of Neurology 1988, 23: 211-222. PMID: 3288084, DOI: 10.1002/ana.410230302.Peer-Reviewed Original ResearchConceptsMultiple sclerosisClinical trialsHelper/inducer cellsOnset of progressionMultiple sclerosis therapyNumber of relapsesPresent treatment modalitiesAntigen-specific cellsActivated T cellsImmune balanceImmunotherapeutic interventionsNonspecific immunosuppressionSclerosis therapyAcute attacksAutoimmune diseasesInducer cellsLymphocyte trafficTreatment modalitiesSuppressor influencesEarly treatmentT cellsEffective treatmentTherapeutic goalsImmunotherapyImmune system
1987
Selective Loss of the Suppressor-Inducer T-Cell Subset in Progressive Multiple Sclerosis
Morimoto C, Hafler D, Weiner H, Letvin N, Hagan M, Daley J, Schlossman S. Selective Loss of the Suppressor-Inducer T-Cell Subset in Progressive Multiple Sclerosis. New England Journal Of Medicine 1987, 316: 67-72. PMID: 2946956, DOI: 10.1056/nejm198701083160202.Peer-Reviewed Original ResearchConceptsProgressive multiple sclerosisMultiple sclerosisStable diseaseHealthy controlsT cellsNeurologic diseaseSuppressor-inducer T cell subsetPeripheral blood lymphocyte subsetsSelective decreaseCubic millimeterPeripheral blood T cellsAnti-2H4 antibodySuppressor T cellsSuppressor T lymphocytesT cell subsetsPercentage of reactivityProduction of IgGCentral nervous systemDual-color fluorescence analysisPolymorphic antigenic determinantsActivation of cellsAnti-2H4Lymphocyte subsetsAcute attacksSuppressor cells