1997
Glomerular epithelial cell products stimulate mesangial cell proliferation in culture
Budde K, Neumayer H, Salant D, Cybulsky A, Coleman D, Sterzel R. Glomerular epithelial cell products stimulate mesangial cell proliferation in culture. Kidney International 1997, 52: 733-741. PMID: 9291194, DOI: 10.1038/ki.1997.389.Peer-Reviewed Original ResearchConceptsGlomerular epithelial cellsMC growth factorsMesangial cellsGlomerular diseaseGrowth factorMesangial cell proliferationEpithelial cell productsQuiescent rat mesangial cellsRat mesangial cellsIL-6IL-4IL-5TNF-alphaIL-2Glomerular cell typesIL-1GM-CSFTGF betaSoluble factorsProliferative activityCell productsCompetitive binding assaysEpithelial cellsMitogenic activityCell proliferation
1994
Serum response elements mediate protein kinase C dependent transcriptional induction of early growth response gene‐1 by arginine vasopressin in rat mesangial cells
Rupprecht H, Sukhatme V, Rupprecht A, Sterzel R, Coleman D. Serum response elements mediate protein kinase C dependent transcriptional induction of early growth response gene‐1 by arginine vasopressin in rat mesangial cells. Journal Of Cellular Physiology 1994, 159: 311-323. PMID: 8163570, DOI: 10.1002/jcp.1041590214.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArginine VasopressinBase SequenceBloodDNA-Binding ProteinsEarly Growth Response Protein 1Enzyme ActivationGene Expression RegulationGlomerular MesangiumHalf-LifeImmediate-Early ProteinsMolecular Sequence DataPromoter Regions, GeneticProtein Kinase CRatsRNA, MessengerTranscription FactorsTranscription, GeneticConceptsEarly growth response gene-1Transcriptional inductionResponse gene-1Egr-1Gene 1Electrophoretic mobility shift assaysDependent transcriptional inductionDNA-protein interactionsPromoter deletion analysisMobility shift assaysIntracellular biochemical eventsProtein kinase CInduction of mitogenesisMesangial cellsEarly gene expressionExtracellular matrix productionDeletion analysisPK CShift assaysTranscriptional levelAVP stimulationHeterologous promoterConsensus sequenceGene expressionPromoter activity
1993
PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements
Rupprecht H, Sukhatme V, Lacy J, Sterzel R, Coleman D. PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements. American Journal Of Physiology 1993, 265: f351-f360. PMID: 8214093, DOI: 10.1152/ajprenal.1993.265.3.f351.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceDNA-Binding ProteinsEarly Growth Response Protein 1Gene ExpressionGlomerular MesangiumImmediate-Early ProteinsMolecular Sequence DataNuclear ProteinsOligonucleotide ProbesPhosphorylationPlatelet-Derived Growth FactorPromoter Regions, GeneticRatsSerum Response FactorTranscription FactorsTranscription, GeneticTyrosineConceptsPlatelet-derived growth factorPDGF stimulationElectrophoretic mobility shift assaysNuclear run-off assaysPromoter deletion analysisEgr-1 transcriptionEarly growth response gene-1Serum response elementUpstream serum response elementsProtein tyrosine phosphorylationMobility shift assaysRun-off assaysResponse gene-1Egr-1 inductionEgr-1 mRNAEgr-1 expressionImmediate early genesTranscriptional inductionDeletion analysisTyrosine phosphorylationShift assaysTranscriptional levelConsensus sequenceTranscription rateGene expression
1992
Effect of vasoactive agents on induction of Egr-1 in rat mesangial cells: correlation with mitogenicity
Rupprecht H, Dann P, Sukhatme V, Sterzel R, Coleman D. Effect of vasoactive agents on induction of Egr-1 in rat mesangial cells: correlation with mitogenicity. American Journal Of Physiology 1992, 263: f623-f636. PMID: 1415734, DOI: 10.1152/ajprenal.1992.263.4.f623.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAnimalsArginine VasopressinDNA-Binding ProteinsEarly Growth Response Protein 1Gene Expression RegulationGlomerular MesangiumImmediate-Early ProteinsMaleMitogensPlatelet-Derived Growth FactorProtein Kinase CRatsRats, Sprague-DawleyRNA, MessengerSerotoninTime FactorsTranscription FactorsVasoconstrictionVasodilationMesangial cell-matrix interactions. Effects on mesangial cell growth and cytokine secretion.
Ruef C, Kashgarian M, Coleman D. Mesangial cell-matrix interactions. Effects on mesangial cell growth and cytokine secretion. American Journal Of Pathology 1992, 141: 429-39. PMID: 1323220, PMCID: PMC1886618.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DivisionCytokinesExtracellular MatrixExtracellular Matrix ProteinsGlomerular MesangiumInterleukin-6Microbial CollagenaseConceptsIL-6 secretionInterleukin-6Mesangial cellsCytokine secretionMC growthIL-6 releaseIL-1 alphaMesangial cell growthDose-dependent mannerMesangioproliferative GNInflammatory mediatorsInflammatory cellsTNF-alphaCollagen type IVCollagen type ISecretionColl IType IVExtracellular matrix proteinsProliferative phenotypeCytokinesType ICell growthMatrix proteinsCellsInterleukin-6: An autocrine regulator of mesangial cell growth
Coleman D, Ruef C. Interleukin-6: An autocrine regulator of mesangial cell growth. Kidney International 1992, 41: 604-606. PMID: 1573836, DOI: 10.1038/ki.1992.91.Peer-Reviewed Original ResearchConceptsInterleukin-6Transgenic miceVivo studiesTransgenic mouse modelMesangial cell growthIL-6 geneGranulocyte-macrophage colonyIgG1 plasmacytosisCytokine productionImmune cellsMesangioproliferative glomerulonephritisInterleukin-1Autocrine regulatorMouse modelGlomerular cellsCell culture modelProliferative effectTarget cellsTissue distributionImmunoglobulin heavy chain enhancerChain enhancerTissue cellsCulture modelMiceNontransformed cell types
1990
Interleukin 6 is an autocrine growth factor for mesangial cells
Ruef C, Budde K, Lacy J, Northemann W, Baumann M, Sterzel R, Coleman D. Interleukin 6 is an autocrine growth factor for mesangial cells. Kidney International 1990, 38: 249-257. PMID: 2402117, DOI: 10.1038/ki.1990.193.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, NorthernCell DivisionCell LineGlomerular MesangiumInterleukin-6MaleRatsRats, Inbred StrainsRecombinant ProteinsConceptsIL-6Autocrine growth factorInterleukin-6T cellsGrowth factorSecrete IL-6Possible paracrine roleAcute phase responseIL-6 mRNADose-dependent increaseIL-6 actsMesangial cell proliferationIL-6 resultsGlomerular inflammationNumber of MCsImmune responseRat MCsParacrine roleB cellsMesangial cellsMC-CMEndothelial cellsAutocrine signalsCell proliferationPlasmacytoma cells
1989
Rat mesangial cells produce granulocyte-macrophage colony-stimulating factor
Budde K, Coleman D, Lacy J, Sterzel R. Rat mesangial cells produce granulocyte-macrophage colony-stimulating factor. American Journal Of Physiology 1989, 257: f1065-f1078. PMID: 2690641, DOI: 10.1152/ajprenal.1989.257.6.f1065.Peer-Reviewed Original ResearchConceptsRat mesangial cellsGranulocyte-macrophage colony-stimulating factorCultured rat mesangial cellsMesangial cellsColony-stimulating factorGM-CSFMC-CMGlomerular mesangial cellsPeritoneal MPsEffector cellsIL-2Inflammatory processGlomerular diseaseInterleukin-2T cellsT lymphocytesInterleukin-4Murine GM-CSFRenal glomeruliSerum-free conditionsSoluble factorsProliferative activitySpecific cDNA probesGM-CSF mRNA transcriptsPresent findings