1999
Constitutive Calcium-independent Release of Toxoplasma gondii Dense Granules Occurs through the NSF/SNAP/SNARE/Rab Machinery*
Chaturvedi S, Qi H, Coleman D, Rodriguez A, Hanson P, Striepen B, Roos D, Joiner K. Constitutive Calcium-independent Release of Toxoplasma gondii Dense Granules Occurs through the NSF/SNAP/SNARE/Rab Machinery*. Journal Of Biological Chemistry 1999, 274: 2424-2431. PMID: 9891012, DOI: 10.1074/jbc.274.4.2424.Peer-Reviewed Original ResearchConceptsN-ethylmaleimide-sensitive fusion proteinDense matrix granulesDense granulesBeta-lactamase secretionMammalian homologueDissociation inhibitorAbsence of ATPPathogenic protozoan parasitesCalcium-independent fashionPermeabilized parasitesFusion proteinProtein componentsProtozoan parasiteCalcium-independent releaseDense granule releaseParasitesMachineryProteinN-ethylmaleimideGuanosine 5'Matrix granulesGranule releaseToxoplasma gondiiGranulesHomologues
1988
Granulocyte-macrophage colony-stimulating factor enhances selective effector functions of tissue-derived macrophages.
Coleman D, Chodakewitz J, Bartiss A, Mellors J. Granulocyte-macrophage colony-stimulating factor enhances selective effector functions of tissue-derived macrophages. Blood 1988, 72: 573-8. PMID: 3042043, DOI: 10.1182/blood.v72.2.573.bloodjournal722573.Peer-Reviewed Original ResearchConceptsFc-dependent phagocytosisAnti-Toxoplasma activityGranulocyte-macrophage colony-stimulating factorGM-CSFColony-stimulating factorTissue-derived macrophagesRecombinant GM-CSFClass II major histocompatibility antigensMacrophage oxidative metabolismMajor histocompatibility antigensSite of exposureGM-CSF antibodyMurine recombinant GM-CSFThioglycollate-elicited cellsPhorbol myristate acetateNeutrophil functionHistocompatibility antigensEffector functionsVariety of cellsFunctional capacityMacrophage functionThioglycollate-elicited macrophagesResident macrophagesPeritoneal macrophagesStimulatory effect
1987
Stimulation of macrophage H2O2 release by resident thymocytes: Effect of a soluble factor distinct from interferon-γ
Mellors J, Bartiss A, Coleman D. Stimulation of macrophage H2O2 release by resident thymocytes: Effect of a soluble factor distinct from interferon-γ. Cellular Immunology 1987, 110: 391-399. PMID: 3121188, DOI: 10.1016/0008-8749(87)90131-6.Peer-Reviewed Original ResearchConceptsT cellsResident thymocytesAntigen-specific immune responsesSoluble factorsMacrophage microbicidal mechanismsRespiratory burst capacityLow molecular weight soluble factorMacrophage oxidative metabolismNonactivated T cellsMacrophage H2O2 releaseActivated T cellsMacrophage effector functionsEnzyme-linked immunosorbentReceptor-mediated phagocytosisImmune responseIFN-gammaEffector functionsToxoplasma gondiiControl macrophagesRespiratory burstMicrobicidal mechanismsPeritoneal macrophagesInterferon activityMacrophagesBurst capacity