1997
Glomerular epithelial cell products stimulate mesangial cell proliferation in culture
Budde K, Neumayer H, Salant D, Cybulsky A, Coleman D, Sterzel R. Glomerular epithelial cell products stimulate mesangial cell proliferation in culture. Kidney International 1997, 52: 733-741. PMID: 9291194, DOI: 10.1038/ki.1997.389.Peer-Reviewed Original ResearchConceptsGlomerular epithelial cellsMC growth factorsMesangial cellsGlomerular diseaseGrowth factorMesangial cell proliferationEpithelial cell productsQuiescent rat mesangial cellsRat mesangial cellsIL-6IL-4IL-5TNF-alphaIL-2Glomerular cell typesIL-1GM-CSFTGF betaSoluble factorsProliferative activityCell productsCompetitive binding assaysEpithelial cellsMitogenic activityCell proliferation
1990
Interleukin 6 is an autocrine growth factor for mesangial cells
Ruef C, Budde K, Lacy J, Northemann W, Baumann M, Sterzel R, Coleman D. Interleukin 6 is an autocrine growth factor for mesangial cells. Kidney International 1990, 38: 249-257. PMID: 2402117, DOI: 10.1038/ki.1990.193.Peer-Reviewed Original ResearchConceptsIL-6Autocrine growth factorInterleukin-6T cellsGrowth factorSecrete IL-6Possible paracrine roleAcute phase responseIL-6 mRNADose-dependent increaseIL-6 actsMesangial cell proliferationIL-6 resultsGlomerular inflammationNumber of MCsImmune responseRat MCsParacrine roleB cellsMesangial cellsMC-CMEndothelial cellsAutocrine signalsCell proliferationPlasmacytoma cells