Mesangial cell-matrix interactions. Effects on mesangial cell growth and cytokine secretion.
Ruef C, Kashgarian M, Coleman D. Mesangial cell-matrix interactions. Effects on mesangial cell growth and cytokine secretion. American Journal Of Pathology 1992, 141: 429-39. PMID: 1323220, PMCID: PMC1886618.Peer-Reviewed Original ResearchConceptsIL-6 secretionInterleukin-6Mesangial cellsCytokine secretionMC growthIL-6 releaseIL-1 alphaMesangial cell growthDose-dependent mannerMesangioproliferative GNInflammatory mediatorsInflammatory cellsTNF-alphaCollagen type IVCollagen type ISecretionColl IType IVExtracellular matrix proteinsProliferative phenotypeCytokinesType ICell growthMatrix proteinsCellsInterleukin-6: An autocrine regulator of mesangial cell growth
Coleman D, Ruef C. Interleukin-6: An autocrine regulator of mesangial cell growth. Kidney International 1992, 41: 604-606. PMID: 1573836, DOI: 10.1038/ki.1992.91.Peer-Reviewed Original ResearchConceptsInterleukin-6Transgenic miceVivo studiesTransgenic mouse modelMesangial cell growthIL-6 geneGranulocyte-macrophage colonyIgG1 plasmacytosisCytokine productionImmune cellsMesangioproliferative glomerulonephritisInterleukin-1Autocrine regulatorMouse modelGlomerular cellsCell culture modelProliferative effectTarget cellsTissue distributionImmunoglobulin heavy chain enhancerChain enhancerTissue cellsCulture modelMiceNontransformed cell types