2013
NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth
Jaba IM, Zhuang ZW, Li N, Jiang Y, Martin KA, Sinusas AJ, Papademetris X, Simons M, Sessa WC, Young LH, Tirziu D. NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth. Journal Of Clinical Investigation 2013, 123: 1718-1731. PMID: 23454748, PMCID: PMC3613910, DOI: 10.1172/jci65112.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, BiologicalAnimalsCell EnlargementCells, CulturedCoronary VesselsEndothelium, VascularHeart VentriclesMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLMice, TransgenicMultiprotein ComplexesMyocytes, CardiacNeovascularization, PhysiologicNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthasePlacenta Growth FactorPregnancy ProteinsProteinsProteolysisProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleyRGS ProteinsSignal TransductionTOR Serine-Threonine KinasesConceptsCardiomyocyte growthAkt/mTORC1 signalingNovel NO-dependent mechanismProteasomal degradationCoordination of angiogenesisMTORC1 signalingConditional overexpressionMurine cardiac tissueG proteinsTransgenic expressionAkt/Physiological mechanismsMyocyte growthVessel growthGrowth factorTransgenic miceHypertrophic responseAngiogenesisKnockout miceMyocardial hypertrophyExpressionGrowthCardiac hypertrophyNOS inhibitor L-NAMEInduction
2008
Molecular Basis for Proline- and Arginine-Rich Peptide Inhibition of Proteasome
Anbanandam A, Albarado DC, Tirziu DC, Simons M, Veeraraghavan S. Molecular Basis for Proline- and Arginine-Rich Peptide Inhibition of Proteasome. Journal Of Molecular Biology 2008, 384: 219-227. PMID: 18823992, PMCID: PMC2632303, DOI: 10.1016/j.jmb.2008.09.021.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAntimicrobial Cationic PeptidesCells, CulturedChymotrypsinEndothelial CellsGene Expression RegulationHumansHydrophobic and Hydrophilic InteractionsMagnetic Resonance SpectroscopyMolecular Sequence DataMutant ProteinsNF-kappa BProteasome InhibitorsTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1
2007
Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice
Tirziu D, Chorianopoulos E, Moodie KL, Palac RT, Zhuang ZW, Tjwa M, Roncal C, Eriksson U, Fu Q, Elfenbein A, Hall AE, Carmeliet P, Moons L, Simons M. Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice. Journal Of Clinical Investigation 2007, 117: 3188-3197. PMID: 17975666, PMCID: PMC2045601, DOI: 10.1172/jci32024.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenic ProteinsAnimalsCardiomegalyCells, CulturedEchocardiographyEndothelial CellsEnzyme InhibitorsHeartHemodynamicsMiceMice, Inbred C57BLMice, TransgenicMyocardiumMyocytes, CardiacNeovascularization, PhysiologicNG-Nitroarginine Methyl EsterOrgan SizeRatsRats, Sprague-DawleyTransgenesConceptsMyocardial hypertrophyHeart sizeNormal heart sizeENOS inhibitor L-NAMEInhibitor L-NAMEAtrial natriuretic factorHypertrophic marker expressionNormal adult mouse heartAdult mouse heartAngiogenic growth factorsL-NAMEBeta-MHCCardiac massMyocardial infarctionMyocardial functionNatriuretic factorCardiac performanceCardiomyocyte sizeTransgenic miceStimulation periodHeart growthHypertrophy markersMarker expressionMouse heartsMurine heart
2006
Syndecan-4 Clustering Induces Cell Migration in a PDZ-Dependent Manner
Tkachenko E, Elfenbein A, Tirziu D, Simons M. Syndecan-4 Clustering Induces Cell Migration in a PDZ-Dependent Manner. Circulation Research 2006, 98: 1398-1404. PMID: 16675718, DOI: 10.1161/01.res.0000225283.71490.5a.Peer-Reviewed Original ResearchConceptsCell migrationPDZ-dependent mannerAdhesion pointsActivation of Rac1Induces cell migrationPDZ domainEndothelial cell migrationFocal adhesionsCytoplasmic domainSignal transductionCell motilityDomain interactionsEndothelial cellsSyndecan-4Cell polarizationPDZRac1Fide receptorLigand clusteringLive cellsDirection of migrationElevated basal levelsSynectinS4 mutantLeading edge