2013
NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth
Jaba IM, Zhuang ZW, Li N, Jiang Y, Martin KA, Sinusas AJ, Papademetris X, Simons M, Sessa WC, Young LH, Tirziu D. NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth. Journal Of Clinical Investigation 2013, 123: 1718-1731. PMID: 23454748, PMCID: PMC3613910, DOI: 10.1172/jci65112.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, BiologicalAnimalsCell EnlargementCells, CulturedCoronary VesselsEndothelium, VascularHeart VentriclesMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLMice, TransgenicMultiprotein ComplexesMyocytes, CardiacNeovascularization, PhysiologicNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthasePlacenta Growth FactorPregnancy ProteinsProteinsProteolysisProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleyRGS ProteinsSignal TransductionTOR Serine-Threonine KinasesConceptsCardiomyocyte growthAkt/mTORC1 signalingNovel NO-dependent mechanismProteasomal degradationCoordination of angiogenesisMTORC1 signalingConditional overexpressionMurine cardiac tissueG proteinsTransgenic expressionAkt/Physiological mechanismsMyocyte growthVessel growthGrowth factorTransgenic miceHypertrophic responseAngiogenesisKnockout miceMyocardial hypertrophyExpressionGrowthCardiac hypertrophyNOS inhibitor L-NAMEInduction
2010
Cell Communications in the Heart
Tirziu D, Giordano FJ, Simons M. Cell Communications in the Heart. Circulation 2010, 122: 928-937. PMID: 20805439, PMCID: PMC2941440, DOI: 10.1161/circulationaha.108.847731.Peer-Reviewed Original Research
2008
Endothelium-Driven Myocardial Growth or Nitric Oxide at the Crossroads
Tirziu D, Simons M. Endothelium-Driven Myocardial Growth or Nitric Oxide at the Crossroads. Trends In Cardiovascular Medicine 2008, 18: 299-305. PMID: 19345317, PMCID: PMC2692333, DOI: 10.1016/j.tcm.2009.01.002.Peer-Reviewed Original ResearchAnimalsBlood Coagulation FactorsCardiomegalyCoronary CirculationEndothelinsEndothelium, VascularFibroblast Growth FactorsHumansIon Channel GatingMyocardiumMyocytes, CardiacNitric OxideNitric Oxide Synthase Type INitric Oxide Synthase Type IIIParacrine CommunicationPlatelet-Derived Growth FactorProstaglandinsSignal TransductionVascular Endothelial Growth FactorsEndothelium as master regulator of organ development and growth
Tirziu D, Simons M. Endothelium as master regulator of organ development and growth. Vascular Pharmacology 2008, 50: 1-7. PMID: 18804188, PMCID: PMC2630387, DOI: 10.1016/j.vph.2008.08.003.Peer-Reviewed Original Research
2007
Protection against myocardial ischemia-reperfusion injury by the angiogenic Masterswitch protein PR 39 gene therapy: the roles of HIF1alpha stabilization and FGFR1 signaling.
Muinck ED, Nagy N, Tirziu D, Murakami M, Gurusamy N, Goswami SK, Ghatpande S, Engelman RM, Simons M, Das DK. Protection against myocardial ischemia-reperfusion injury by the angiogenic Masterswitch protein PR 39 gene therapy: the roles of HIF1alpha stabilization and FGFR1 signaling. Antioxidants & Redox Signaling 2007, 9: 437-45. PMID: 17280485, DOI: 10.1089/ars.2006.1501.Peer-Reviewed Original ResearchMeSH KeywordsAdenoviridaeAnimalsAntimicrobial Cationic PeptidesApoptosisBlotting, WesternCell LineGenetic TherapyHumansHypoxia-Inducible Factor 1, alpha SubunitIn Situ Nick-End LabelingMaleMalondialdehydeMiceMice, Inbred C57BLMutationMyocardial Reperfusion InjuryReactive Oxygen SpeciesReceptor, Fibroblast Growth Factor, Type 1Signal TransductionTime FactorsConceptsCoronary flowMyocardial ischemic reperfusion injuryMyocardial ischemia-reperfusion injuryEmpty vectorIschemia-reperfusion injuryIschemic reperfusion injuryLVdP/dtVentricular developed pressureMin of ischemiaBaseline coronary flowMyocardial infarct sizeGene therapyReperfusion injuryCardioprotective abilityInfarct sizeDeveloped pressureHIF-1alpha proteinTTC stainingAortic flowHeart rateCardiomyocyte apoptosisEx vivoCardioprotectionHIF1alpha stabilizationHemodynamics
2006
Syndecan-4 Clustering Induces Cell Migration in a PDZ-Dependent Manner
Tkachenko E, Elfenbein A, Tirziu D, Simons M. Syndecan-4 Clustering Induces Cell Migration in a PDZ-Dependent Manner. Circulation Research 2006, 98: 1398-1404. PMID: 16675718, DOI: 10.1161/01.res.0000225283.71490.5a.Peer-Reviewed Original ResearchConceptsCell migrationPDZ-dependent mannerAdhesion pointsActivation of Rac1Induces cell migrationPDZ domainEndothelial cell migrationFocal adhesionsCytoplasmic domainSignal transductionCell motilityDomain interactionsEndothelial cellsSyndecan-4Cell polarizationPDZRac1Fide receptorLigand clusteringLive cellsDirection of migrationElevated basal levelsSynectinS4 mutantLeading edge