2023
Impact and Implications of Neurocognitive Dysfunction in the Management of Ischemic Heart Failure
Tirziu D, Kołodziejczak M, Grubman D, Carrión C, Driskell L, Ahmad Y, Petrie M, Omerovic E, Redfors B, Fremes S, Browndyke J, Lansky A. Impact and Implications of Neurocognitive Dysfunction in the Management of Ischemic Heart Failure. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101198. PMID: 39131066, PMCID: PMC11308118, DOI: 10.1016/j.jscai.2023.101198.Peer-Reviewed Original ResearchIschemic heart failureHeart failureNeurocognitive dysfunctionCognitive impairmentCoronary Artery Bypass GraftingArtery Bypass GraftingChronic cerebral hypoperfusionCoronary artery bypassPercutaneous coronary interventionPoor cognitive functionArtery bypassBypass GraftingCardiovascular outcomesCerebral hypoperfusionCoronary revascularizationCerebral hypoxiaCoronary interventionNeurologic injuryCardiac outputWorse outcomesBrain damageBrain injuryPatient outcomesInvasive approachPatient managementAntiplatelet Strategies Following PCI: A Review of Trials Informing Current and Future Therapies
Thomas A, Gitto M, Shah S, Saito Y, Tirziu D, Chieffo A, Stefanini G, Lansky A. Antiplatelet Strategies Following PCI: A Review of Trials Informing Current and Future Therapies. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100607. PMID: 39130709, PMCID: PMC11307978, DOI: 10.1016/j.jscai.2023.100607.Peer-Reviewed Original ResearchDual antiplatelet therapyAntiplatelet regimensPatient-specific risk profileShorter DAPT durationDuration of therapyPercutaneous coronary interventionDAPT strategyIschemic riskAntiplatelet therapyDAPT durationAntiplatelet strategiesCoronary interventionOngoing trialsMajor trialsRecent trialsPractice guidelinesFuture therapiesRisk profileTherapyStent technologyTrialsRegimensNumber of trialsSignificant reductionSignificant changes
2022
Impella Versus Intra-Aortic Balloon Pump for High-Risk PCI: A Propensity-Adjusted Large-Scale Claims Dataset Analysis
Lansky AJ, Tirziu D, Moses JW, Pietras C, Ohman EM, O'Neill WW, Ekono MM, Grines CL, Parise H. Impella Versus Intra-Aortic Balloon Pump for High-Risk PCI: A Propensity-Adjusted Large-Scale Claims Dataset Analysis. The American Journal Of Cardiology 2022, 185: 29-36. PMID: 36210212, DOI: 10.1016/j.amjcard.2022.08.032.Peer-Reviewed Original ResearchConceptsHigh-risk percutaneous coronary interventionIntra-aortic balloon pumpPercutaneous coronary interventionAcute kidney injuryCardiogenic shockMyocardial infarctionIABP supportKidney injuryBalloon pumpImproved survivalPropensity adjustmentAcute ST-elevation myocardial infarctionST-elevation myocardial infarctionIndex hospitalization lengthLess myocardial infarctionPremier Healthcare DatabaseHospital myocardial infarctionPropensity-adjusted analysisMechanical circulatory supportMechanical support devicesImpella useHospital survivalIndex hospitalizationCoronary interventionReal-world practice
2021
Long term outcomes of ultrathin versus standard thickness second‐generation drug eluting stents: Meta‐analysis of randomized trials
Hussain Y, Gaston S, Kluger J, Shah T, Yang Y, Tirziu D, Lansky A. Long term outcomes of ultrathin versus standard thickness second‐generation drug eluting stents: Meta‐analysis of randomized trials. Catheterization And Cardiovascular Interventions 2021, 99: 563-574. PMID: 34236755, DOI: 10.1002/ccd.29866.Peer-Reviewed Original ResearchConceptsSecond generation drug eluting stentsTarget lesion failureDrug eluting stentsLong-term outcomesEluting stentsTerm outcomesRisk ratioIschemia-driven target vessel revascularizationTarget vessel myocardial infarctionLong-term clinical outcomesProbable stent thrombosisTarget vessel revascularizationTerm clinical outcomesVessel myocardial infarctionPercutaneous coronary interventionCoronary artery diseaseConfidence intervalsFirst generation drug eluting stentsRandom-effects modelLesion failureVessel revascularizationCoronary interventionSecondary outcomesArtery diseaseCardiac deathMeta-Analysis of Gender Disparities in In-hospital Care and Outcomes in Patients with ST-Segment Elevation Myocardial Infarction
Shah T, Haimi I, Yang Y, Gaston S, Taoutel R, Mehta S, Lee HJ, Zambahari R, Baumbach A, Henry TD, Grines CL, Lansky A, Tirziu D. Meta-Analysis of Gender Disparities in In-hospital Care and Outcomes in Patients with ST-Segment Elevation Myocardial Infarction. The American Journal Of Cardiology 2021, 147: 23-32. PMID: 33640366, DOI: 10.1016/j.amjcard.2021.02.015.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionPrimary PCIMyocardial infarctionMajor bleedingBalloon timeST-segment elevation myocardial infarctionMyocardial infarction outcomesRepeat myocardial infarctionFirst medical contactElevation myocardial infarctionPercutaneous coronary interventionSpecific patient characteristicsRate of mortalityAspirin usageMore comorbiditiesAntiplatelet therapyHospital outcomesP2Y12 inhibitorsCoronary interventionLonger doorPatient characteristicsMedical contactClinical outcomesGender disparitiesSuboptimal treatment