2023
Persistence of Pneumococcal Carriage among Older Adults in the Community despite COVID-19 Mitigation Measures
Wyllie A, Mbodj S, Thammavongsa D, Hislop M, Yolda-Carr D, Waghela P, Nakahata M, Stahlfeld A, Vega N, York A, Allicock O, Wilkins G, Ouyang A, Siqueiros L, Strong Y, Anastasio K, Alexander-Parrish R, Arguedas A, Gessner B, Weinberger D. Persistence of Pneumococcal Carriage among Older Adults in the Community despite COVID-19 Mitigation Measures. Microbiology Spectrum 2023, 11: e04879-22. PMID: 37036377, PMCID: PMC10269788, DOI: 10.1128/spectrum.04879-22.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseasePneumococcal diseaseSchool-aged childrenOlder adultsPneumococcal carriageSaliva samplesCOVID-19 pandemicRate of carriageCOVID-19-related disruptionsUpper respiratory tractRegular contactNew Haven areaFirst yearCarriage prevalencePre-pandemic levelsMedical historyRespiratory tractHigh prevalenceStreptococcus pneumoniaeCOVID-19 mitigation measuresStudy participantsPneumococciPrevalenceDiseaseCarriage
2022
Predicting vaccine effectiveness against invasive pneumococcal disease in children using immunogenicity data
Ryman J, Weaver J, Hu T, Weinberger D, Yee K, Sachs J. Predicting vaccine effectiveness against invasive pneumococcal disease in children using immunogenicity data. Npj Vaccines 2022, 7: 140. PMID: 36344529, PMCID: PMC9640717, DOI: 10.1038/s41541-022-00538-1.Peer-Reviewed Original ResearchPneumococcal conjugate vaccineSerotype-specific IgG concentrationsInvasive pneumococcal diseaseVaccine effectivenessIgG concentrationsPneumococcal diseaseImmune responseAntibody concentrationsProtective antibody concentrationsNext-generation vaccinesPCV13 recipientsConjugate vaccineImmunogenicity dataPCV7PCV13SerotypesVaccineDiseasePlaceboImmunogenicityRecipients
2015
Association Between Local Pediatric Vaccination Rates and Patterns of Pneumococcal Disease in Adults
Pingali SC, Warren JL, Mead AM, Sharova N, Petit S, Weinberger DM. Association Between Local Pediatric Vaccination Rates and Patterns of Pneumococcal Disease in Adults. The Journal Of Infectious Diseases 2015, 213: 509-515. PMID: 26310307, PMCID: PMC4721904, DOI: 10.1093/infdis/jiv431.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseasePneumococcal diseaseIPD casesPopulation-based surveillance systemZip code level dataAdult IPD casesDoses of PCV7Effectiveness of PCVsPediatric vaccination ratesVaccination of childrenState immunization registryZip codesLogistic regression modelsPCV7 serotypesHigher proportionVaccination ratesImmunization registryDisease patternsDiseaseAdultsPCV7PCVSerotypesChildrenDoses
2011
Impact of the 2009 Influenza Pandemic on Pneumococcal Pneumonia Hospitalizations in the United States
Weinberger DM, Simonsen L, Jordan R, Steiner C, Miller M, Viboud C. Impact of the 2009 Influenza Pandemic on Pneumococcal Pneumonia Hospitalizations in the United States. The Journal Of Infectious Diseases 2011, 205: 458-465. PMID: 22158564, PMCID: PMC3276240, DOI: 10.1093/infdis/jir749.Peer-Reviewed Original ResearchConceptsPneumococcal pneumonia hospitalizationsInfluenza pandemicPneumonia hospitalizationsPneumococcal diseaseInfluenza activityCause-specific hospitalizationsPandemic influenza activityPneumonia hospitalization ratesH1N1 influenza pandemicState Inpatient DatabasesLow baseline levelsHospitalization ratesInpatient DatabaseWeekly ageHospitalizationHealthcare costsExcess diseaseLargest absolute increaseBaseline levelsAge groupsInfluenza virusAbsolute increaseInfluenza waveDiseaseSignificant increaseSerotype replacement in disease after pneumococcal vaccination
Weinberger DM, Malley R, Lipsitch M. Serotype replacement in disease after pneumococcal vaccination. The Lancet 2011, 378: 1962-1973. PMID: 21492929, PMCID: PMC3256741, DOI: 10.1016/s0140-6736(10)62225-8.Peer-Reviewed Original ResearchConceptsNon-vaccine serotypesSerotype replacementPneumococcal diseaseHeptavalent pneumococcal conjugate vaccinePneumococcal conjugate vaccineImportant public health benefitsBenefits of vaccinationPublic health benefitsDisease surveillance systemsNVT carriagePneumococcal vaccinationSurveillance biasesConjugate vaccineVaccine serotypesCarriage prevalencePneumococcal serotypesAsymptomatic carriersCarriage dataDiseaseVaccinationHealth benefitsLow invasivenessPrevalenceSerotypesCarriage