2022
Understanding the complex genetic architecture connecting rheumatoid arthritis, osteoporosis and inflammation: discovering causal pathways
Kasher M, Williams F, Freidin M, Malkin I, Cherny S, Benjamin E, Chasman D, Dehghan A, Ahluwalia T, Meigs J, Tracy R, Alizadeh B, Ligthart S, Bis J, Eiriksdottir G, Pankratz N, Gross M, Rainer A, Snieder H, Wilson J, Psaty B, Dupuis J, Prins B, Vaso U, Stathopoulou M, Franke L, Lehtimaki T, Koenig W, Jamshidi Y, Siest S, Abbasi A, Uitterlinden A, Abdollahi M, Schnabel R, Schick U, Nolte I, Kraja A, Hsu Y, Tylee D, Zwicker A, Uher R, Davey-Smith G, Morrison A, Hicks A, van Duijn C, Ward-Caviness C, Boerwinkle E, Rotter J, Rice K, Lange L, Perola M, de Geus E, Morris A, Makela K, Stacey D, Eriksson J, Frayling T, Slagboom E, Livshits G. Understanding the complex genetic architecture connecting rheumatoid arthritis, osteoporosis and inflammation: discovering causal pathways. Human Molecular Genetics 2022, 31: 2623-2632. PMID: 35349660, PMCID: PMC9402243, DOI: 10.1093/hmg/ddac061.Peer-Reviewed Original ResearchMeSH KeywordsArthritis, RheumatoidC-Reactive ProteinGenome-Wide Association StudyHumansInflammationMendelian Randomization AnalysisOsteoporosisPolymorphism, Single NucleotideConceptsCausal single nucleotide polymorphismsSingle nucleotide polymorphismsGenetic architectureColocalization analysisSame molecular functionAnalysis of pleiotropyComplex genetic architectureGenome-wide association study summary statisticsOp phenotypeMolecular functionsGenomic regionsPleiotropyOsteoporosis ConsortiumGenetic relationshipsGenetic backgroundGenetic variantsNucleotide polymorphismsMendelian randomizationGenesTraitsPhenotypeGenetic factorsProtein bindingUK BiobankHorizontal pleiotropy
2020
Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes
Georgakis M, Malik R, Gill D, Franceschini N, Sudlow C, Dichgans M, Lindstrom S, Wang L, Smith E, Gordon W, van Hylckama Vlieg A, de Andrade M, Brody J, Pattee J, Haessler J, Brumpton B, Chasman D, Suchon P, Chen M, Turman C, Germain M, Wiggins K, MacDonald J, Braekkan S, Armasu S, Pankratz N, Jackson R, Nielsen J, Giulianini F, Puurunen M, Ibrahim M, Heckbert S, Damrauer S, Natarajan P, Klarin D, de Vries P, SabaterLleal M, Huffman J, Bammler T, Frazer K, McCauley B, Taylor K, Pankow J, Reiner A, Gabrielsen M, Deleuze J, O’Donnell C, Kim J, McKnight B, Kraft P, Hansen J, Rosendaal F, Heit J, Psaty B, Tang W, Kooperberg C, Hveem K, Ridker P, Morange P, Johnson A, Kabrhel C, Trégouët D, Smith N, Benjamin E, Chasman D, Dehghan A, Ahluwalia T, Meigs J, Tracy R, Alizadeh B, Ligthart S, Bis J, Eiriksdottir G, Pankratz N, Gross M, Rainer A, Snieder H, Wilson J, Psaty B, Dupuis J, Prins B, Vaso U, Stathopoulou M, Franke L, Lehtimaki T, Koenig W, Jamshidi Y, Siest S, Abbasi A, Uitterlinden A, Abdollahi M, Schnabel R, Schick U, Nolte I, Kraja A, Hsu Y, Tylee D, Zwicker A, Uher R, Davey-Smith G, Morrison A, Hicks A, van Duijn C, Ward-Caviness C, Boerwinkle E, Rotter J, Rice K, Lange L, Perola M, de Geus E, Morris A, Makela K, Stacey D, Eriksson J, Frayling T, Slagboom E. Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes. Circulation Genomic And Precision Medicine 2020, 13: e002872-e002872. PMID: 32397738, PMCID: PMC7299212, DOI: 10.1161/circgen.119.002872.Peer-Reviewed Original ResearchFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansInterleukin-6Ischemic StrokeMaleMendelian Randomization AnalysisSignal Transduction
2018
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders
Ligthart S, Vaez A, Võsa U, Stathopoulou M, de Vries P, Prins B, Van der Most P, Tanaka T, Naderi E, Rose L, Wu Y, Karlsson R, Barbalic M, Lin H, Pool R, Zhu G, Macé A, Sidore C, Trompet S, Mangino M, Sabater-Lleal M, Kemp J, Abbasi A, Kacprowski T, Verweij N, Smith A, Huang T, Marzi C, Feitosa M, Lohman K, Kleber M, Milaneschi Y, Mueller C, Huq M, Vlachopoulou E, Lyytikäinen L, Oldmeadow C, Deelen J, Perola M, Zhao J, Feenstra B, Amini M, Lahti J, Schraut K, Fornage M, Suktitipat B, Chen W, Li X, Nutile T, Malerba G, Luan J, Bak T, Schork N, Del Greco M. F, Thiering E, Mahajan A, Marioni R, Mihailov E, Eriksson J, Ozel A, Zhang W, Nethander M, Cheng Y, Aslibekyan S, Ang W, Gandin I, Yengo L, Portas L, Kooperberg C, Hofer E, Rajan K, Schurmann C, Hollander W, Ahluwalia T, Zhao J, Draisma H, Ford I, Timpson N, Teumer A, Huang H, Wahl S, Liu Y, Huang J, Uh H, Geller F, Joshi P, Yanek L, Trabetti E, Lehne B, Vozzi D, Verbanck M, Biino G, Saba Y, Meulenbelt I, O’Connell J, Laakso M, Giulianini F, Magnusson P, Ballantyne C, Hottenga J, Montgomery G, Rivadineira F, Rueedi R, Steri M, Herzig K, Stott D, Menni C, Frånberg M, St. Pourcain B, Felix S, Pers T, Bakker S, Kraft P, Peters A, Vaidya D, Delgado G, Smit J, Großmann V, Sinisalo J, Seppälä I, Williams S, Holliday E, Moed M, Langenberg C, Räikkönen K, Ding J, Campbell H, Sale M, Chen Y, James A, Ruggiero D, Soranzo N, Hartman C, Smith E, Berenson G, Fuchsberger C, Hernandez D, Tiesler C, Giedraitis V, Liewald D, Fischer K, Mellström D, Larsson A, Wang Y, Scott W, Lorentzon M, Beilby J, Ryan K, Pennell C, Vuckovic D, Balkau B, Concas M, Schmidt R, de Leon C, Bottinger E, Kloppenburg M, Paternoster L, Boehnke M, Musk A, Willemsen G, Evans D, Madden P, Kähönen M, Kutalik Z, Zoledziewska M, Karhunen V, Kritchevsky S, Sattar N, Lachance G, Clarke R, Harris T, Raitakari O, Attia J, van Heemst D, Kajantie E, Sorice R, Gambaro G, Scott R, Hicks A, Ferrucci L, Standl M, Lindgren C, Starr J, Karlsson M, Lind L, Li J, Chambers J, Mori T, de Geus E, Heath A, Martin N, Auvinen J, Buckley B, de Craen A, Waldenberger M, Strauch K, Meitinger T, Scott R, McEvoy M, Beekman M, Bombieri C, Ridker P, Mohlke K, Pedersen N, Morrison A, Boomsma D, Whitfield J, Strachan D, Hofman A, Vollenweider P, Cucca F, Jarvelin M, Jukema J, Spector T, Hamsten A, Zeller T, Uitterlinden A, Nauck M, Gudnason V, Qi L, Grallert H, Borecki I, Rotter J, März W, Wild P, Lokki M, Boyle M, Salomaa V, Melbye M, Eriksson J, Wilson J, Penninx B, Becker D, Worrall B, Gibson G, Krauss R, Ciullo M, Zaza G, Wareham N, Oldehinkel A, Palmer L, Murray S, Pramstaller P, Bandinelli S, Heinrich J, Ingelsson E, Deary I, Mägi R, Vandenput L, van der Harst P, Desch K, Kooner J, Ohlsson C, Hayward C, Lehtimäki T, Shuldiner A, Arnett D, Beilin L, Robino A, Froguel P, Pirastu M, Jess T, Koenig W, Loos R, Evans D, Schmidt H, Smith G, Slagboom E, Eiriksdottir G, Morris A, Psaty B, Tracy R, Nolte I, Boerwinkle E, Visvikis-Siest S, Reiner A, Gross M, Bis J, Franke L, Franco O, Benjamin E, Chasman D, Dupuis J, Snieder H, Dehghan A, Alizadeh B, Alizadeh B, Boezen H, Franke L, van der Harst P, Navis G, Rots M, Snieder H, Swertz M, Wolffenbuttel B, Wijmenga C, Benjamin E, Chasman D, Dehghan A, Ahluwalia T, Meigs J, Tracy R, Alizadeh B, Ligthart S, Bis J, Eiriksdottir G, Pankratz N, Gross M, Rainer A, Snieder H, Wilson J, Psaty B, Dupuis J, Prins B, Vaso U, Stathopoulou M, Franke L, Lehtimaki T, Koenig W, Jamshidi Y, Siest S, Abbasi A, Uitterlinden A, Abdollahi M, Schnabel R, Schick U, Nolte I, Kraja A, Hsu Y, Tylee D, Zwicker A, Uher R, Davey-Smith G, Morrison A, Hicks A, van Duijn C, Ward-Caviness C, Boerwinkle E, Rotter J, Rice K, Lange L, Perola M, de Geus E, Morris A, Makela K, Stacey D, Eriksson J, Frayling T, Slagboom P. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. American Journal Of Human Genetics 2018, 103: 691-706. PMID: 30388399, PMCID: PMC6218410, DOI: 10.1016/j.ajhg.2018.09.009.Peer-Reviewed Original ResearchConceptsC-reactive proteinAmount of CRPGenome-wide association studiesMendelian randomization analysisClinical outcomesChronic inflammationChronic low-grade inflammationLow-grade inflammationRandomization analysisBody mass indexBiology of inflammationCausal protective effectDistinct genetic lociRisk-increasing effectSilico functional analysisMass indexProtective effectClinical consequencesMultiple complex diseasesImmune pathwaysInflammationBipolar disorderSensitive biomarkerGenome analysisHighlight pathways