2023
Sex differences in the polygenic architecture of hearing problems in adults
De Angelis F, Zeleznik O, Wendt F, Pathak G, Tylee D, De Lillo A, Koller D, Cabrera-Mendoza B, Clifford R, Maihofer A, Nievergelt C, Curhan G, Curhan S, Polimanti R. Sex differences in the polygenic architecture of hearing problems in adults. Genome Medicine 2023, 15: 36. PMID: 37165447, PMCID: PMC10173489, DOI: 10.1186/s13073-023-01186-3.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleFollow-Up StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyHearingHumansMaleMultifactorial InheritanceSex CharacteristicsConceptsPolygenic architectureRisk lociGenome-wide investigationLarge-scale genetic studiesTranscriptomic regulationGWAS findingsTranscriptomic associationsGene interactionsPotential roleRegulation analysisGenetic studiesInference analysisMillion Veteran ProgramHealth Professionals FollowMolecular pathwaysPolygenic riskPreventive screening programsMultivariate interaction analysisNovel insightsCentral nervous systemEnvironmental risk factorsSex-stratified analysesSex-specific analysesSex differencesMental health outcomes
2022
Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records
Polimanti R, Wendt FR, Pathak GA, Tylee DS, Tcheandjieu C, Hilliard AT, Levey DF, Adhikari K, Gaziano JM, O’Donnell C, Assimes TL, Stein MB, Gelernter J. Understanding the comorbidity between posttraumatic stress severity and coronary artery disease using genome-wide information and electronic health records. Molecular Psychiatry 2022, 27: 3961-3969. PMID: 35986173, PMCID: PMC10986859, DOI: 10.1038/s41380-022-01735-z.Peer-Reviewed Original ResearchMeSH KeywordsComorbidityCoronary Artery DiseaseElectronic Health RecordsGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPolymorphism, Single NucleotideRisk FactorsStress Disorders, Post-TraumaticConceptsCoronary artery diseasePosttraumatic stress disorderElectronic health recordsMillion Veteran ProgramArtery diseaseTotal scoreCAD diagnosisPlatelet amyloid precursor proteinHealth recordsPosttraumatic stress severityAmyloid precursor proteinEarly CAD diagnosisUK BiobankBidirectional relationshipTwo-sample Mendelian randomization (MR) analysisMendelian randomization analysisCAD riskHigh morbidityPTSD symptom severityCARDIoGRAMplusC4D consortiumPleiotropic mechanismsSymptom severityLongitudinal changesDiscordant effectsStress disorder
2020
Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes
Georgakis M, Malik R, Gill D, Franceschini N, Sudlow C, Dichgans M, Lindstrom S, Wang L, Smith E, Gordon W, van Hylckama Vlieg A, de Andrade M, Brody J, Pattee J, Haessler J, Brumpton B, Chasman D, Suchon P, Chen M, Turman C, Germain M, Wiggins K, MacDonald J, Braekkan S, Armasu S, Pankratz N, Jackson R, Nielsen J, Giulianini F, Puurunen M, Ibrahim M, Heckbert S, Damrauer S, Natarajan P, Klarin D, de Vries P, SabaterLleal M, Huffman J, Bammler T, Frazer K, McCauley B, Taylor K, Pankow J, Reiner A, Gabrielsen M, Deleuze J, O’Donnell C, Kim J, McKnight B, Kraft P, Hansen J, Rosendaal F, Heit J, Psaty B, Tang W, Kooperberg C, Hveem K, Ridker P, Morange P, Johnson A, Kabrhel C, Trégouët D, Smith N, Benjamin E, Chasman D, Dehghan A, Ahluwalia T, Meigs J, Tracy R, Alizadeh B, Ligthart S, Bis J, Eiriksdottir G, Pankratz N, Gross M, Rainer A, Snieder H, Wilson J, Psaty B, Dupuis J, Prins B, Vaso U, Stathopoulou M, Franke L, Lehtimaki T, Koenig W, Jamshidi Y, Siest S, Abbasi A, Uitterlinden A, Abdollahi M, Schnabel R, Schick U, Nolte I, Kraja A, Hsu Y, Tylee D, Zwicker A, Uher R, Davey-Smith G, Morrison A, Hicks A, van Duijn C, Ward-Caviness C, Boerwinkle E, Rotter J, Rice K, Lange L, Perola M, de Geus E, Morris A, Makela K, Stacey D, Eriksson J, Frayling T, Slagboom E. Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes. Circulation Genomic And Precision Medicine 2020, 13: e002872-e002872. PMID: 32397738, PMCID: PMC7299212, DOI: 10.1161/circgen.119.002872.Peer-Reviewed Original ResearchFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansInterleukin-6Ischemic StrokeMaleMendelian Randomization AnalysisSignal Transduction
2019
A polygenic resilience score moderates the genetic risk for schizophrenia
Hess JL, Tylee DS, Mattheisen M, Børglum A, Als T, Grove J, Werge T, Mortensen P, Mors O, Nordentoft M, Hougaard D, Byberg-Grauholm J, Bækvad-Hansen M, Greenwood T, Tsuang M, Curtis D, Steinberg S, Sigurdsson E, Stefánsson H, Stefánsson K, Edenberg H, Holmans P, Faraone S, Glatt S. A polygenic resilience score moderates the genetic risk for schizophrenia. Molecular Psychiatry 2019, 26: 800-815. PMID: 31492941, PMCID: PMC7058518, DOI: 10.1038/s41380-019-0463-8.Peer-Reviewed Original ResearchAllelesGenetic Predisposition to DiseaseGenome-Wide Association StudyGenomicsHumansMultifactorial InheritancePolymorphism, Single NucleotideRisk FactorsSchizophrenia
2018
Genetic correlations among psychiatric and immune‐related phenotypes based on genome‐wide association data
Tylee DS, Sun J, Hess JL, Tahir MA, Sharma E, Malik R, Worrall BB, Levine AJ, Martinson JJ, Nejentsev S, Speed D, Fischer A, Mick E, Walker BR, Crawford A, Grant SFA, Polychronakos C, Bradfield JP, Sleiman PMA, Hakonarson H, Ellinghaus E, Elder JT, Tsoi LC, Trembath RC, Barker JN, Franke A, Dehghan A, Team T, Consortium T, Consortium T, Registry T, Group T, Consortium T, Faraone SV, Glatt SJ. Genetic correlations among psychiatric and immune‐related phenotypes based on genome‐wide association data. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2018, 177: 641-657. PMID: 30325587, PMCID: PMC6230304, DOI: 10.1002/ajmg.b.32652.Peer-Reviewed Original ResearchConceptsImmune-related phenotypesPsychiatric disordersSystemic lupus erythematosusPrimary biliary cirrhosisLinkage disequilibrium score regressionImmune-related disordersAttention deficit hyperactivity disorderAutoimmune comorbiditiesDeficit hyperactivity disorderLupus erythematosusUlcerative colitisBiliary cirrhosisCrohn's diseaseObsessive-compulsive disorderMajor depressionImmunological stateSmoking behaviorTourette syndromeBipolar disorderAnorexia nervosaSummary-level dataEpidemiological literatureImmune signalingRespective disordersDisorders
2013
Blood‐based gene‐expression predictors of PTSD risk and resilience among deployed marines: A pilot study
Glatt SJ, Tylee DS, Chandler SD, Pazol J, Nievergelt CM, Woelk CH, Baker DG, Lohr JB, Kremen WS, Litz BT, Tsuang MT, Investigators M. Blood‐based gene‐expression predictors of PTSD risk and resilience among deployed marines: A pilot study. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2013, 162: 313-326. PMID: 23650250, DOI: 10.1002/ajmg.b.32167.Peer-Reviewed Original ResearchConceptsPeripheral blood cellsPeripheral bloodBlood cellsPTSD casesHigh-risk individualsPeripheral blood samplesPanel of biomarkersExpression levelsGene expression levelsPredictive biomarker panelPredictive panelHigh riskBlood samplesBiomarker panelEarly interventionGene expression predictorsTrauma exposurePTSD riskPilot studyBloodImmune genesIndependent samplesFull-length gene transcriptsPTSDRisk