2024
47. GENE DISCOVERY AND BIOLOGICAL INSIGHTS INTO ANXIETY DISORDERS FROM A MULTI-ANCESTRY GENOME-WIDE ASSOCIATION STUDY OF > 1.2 MILLION PARTICIPANTS
Friligkou E, Løkhammer S, Mendoza B, Shen J, He J, Deiana G, Zanoaga M, Asgel Z, Pilcher A, Di Lascio L, Makharashvili A, Koller D, Tylee D, Pathak G, Polimanti R. 47. GENE DISCOVERY AND BIOLOGICAL INSIGHTS INTO ANXIETY DISORDERS FROM A MULTI-ANCESTRY GENOME-WIDE ASSOCIATION STUDY OF > 1.2 MILLION PARTICIPANTS. European Neuropsychopharmacology 2024, 87: 74-75. DOI: 10.1016/j.euroneuro.2024.08.161.Peer-Reviewed Original ResearchMillion Veteran ProgramPolygenic riskLatent causal variable methodMulti-tissue transcriptome-wide association studyUK Biobank (UKBGenetic correlationsTranscriptome-wide association studyAnxiety disordersGenomic structural equation modelingLD score regressionLocal genetic correlationGWAS meta-analysisProteome-wide analysisGenetics of anxietyAssociated with anxietyMulti-omics informationS-MultiXcanVeteran ProgramLD scoresAncestry-specificTranscriptome-wideAncestral populationsCross-ancestryGene discoveryAssociation studies
2023
Sex differences in the polygenic architecture of hearing problems in adults
De Angelis F, Zeleznik O, Wendt F, Pathak G, Tylee D, De Lillo A, Koller D, Cabrera-Mendoza B, Clifford R, Maihofer A, Nievergelt C, Curhan G, Curhan S, Polimanti R. Sex differences in the polygenic architecture of hearing problems in adults. Genome Medicine 2023, 15: 36. PMID: 37165447, PMCID: PMC10173489, DOI: 10.1186/s13073-023-01186-3.Peer-Reviewed Original ResearchConceptsPolygenic architectureRisk lociGenome-wide investigationLarge-scale genetic studiesTranscriptomic regulationGWAS findingsTranscriptomic associationsGene interactionsPotential roleRegulation analysisGenetic studiesInference analysisMillion Veteran ProgramHealth Professionals FollowMolecular pathwaysPolygenic riskPreventive screening programsMultivariate interaction analysisNovel insightsCentral nervous systemEnvironmental risk factorsSex-stratified analysesSex-specific analysesSex differencesMental health outcomes
2021
Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic risk
De Angelis F, Wendt FR, Pathak GA, Tylee DS, Goswami A, Gelernter J, Polimanti R. Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic risk. Translational Psychiatry 2021, 11: 586. PMID: 34775470, PMCID: PMC8590689, DOI: 10.1038/s41398-021-01713-z.Peer-Reviewed Original ResearchConceptsSubstance useYoung adultsBehavioral traitsPhiladelphia Neurodevelopmental CohortRemoval of participantsAnxiety-related traitsRisk-taking behaviorVerbal reasoningCognitive performancePolygenic risk scoresSocial competenciesNeurobiological processesNeurodevelopmental CohortPsychiatric genetic riskDrinking behaviorParent educationPRS associationsPolygenic riskPsychopathologyGenetic overlapPsychotic symptomsAdverse health outcomesHazardous behaviorEducational attainmentTobacco smoking