2017
PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways across Biological Sex and Modes of Trauma
Breen MS, Tylee DS, Maihofer AX, Neylan TC, Mehta D, Binder EB, Chandler SD, Hess JL, Kremen WS, Risbrough VB, Woelk CH, Baker DG, Nievergelt CM, Tsuang MT, Buxbaum JD, Glatt SJ. PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways across Biological Sex and Modes of Trauma. Neuropsychopharmacology 2017, 43: 469-481. PMID: 28925389, PMCID: PMC5770765, DOI: 10.1038/npp.2017.220.Peer-Reviewed Original ResearchConceptsDistinct gene expression perturbationsCo-expression network analysisMitogen-activated protein kinase activityCommon signaling cascadesGene expression perturbationsProtein kinase activityTranscriptome-wide screenDistinct biological pathwaysMolecular convergenceGene expression signaturesTranscriptome studiesExpression perturbationsTranscriptional dysregulationSignaling cascadesKinase activityBiological pathwaysExpression signaturesType I interferonWidespread immune dysregulationInnate immuneLipid metabolismPathwayI interferonNetwork analysisDysregulation
2016
RNA sequencing of transformed lymphoblastoid cells from siblings discordant for autism spectrum disorders reveals transcriptomic and functional alterations: Evidence for sex‐specific effects
Tylee DS, Espinoza AJ, Hess JL, Tahir MA, McCoy SY, Rim JK, Dhimal T, Cohen OS, Glatt SJ. RNA sequencing of transformed lymphoblastoid cells from siblings discordant for autism spectrum disorders reveals transcriptomic and functional alterations: Evidence for sex‐specific effects. Autism Research 2016, 10: 439-455. PMID: 27529825, DOI: 10.1002/aur.1679.Peer-Reviewed Original ResearchConceptsTranscriptomic differencesGenome-wide expression studiesGene co-expression network analysisCo-expression network analysisTranscriptomic signaturesGene-set analysisStructural genetic variantsIdentified transcriptsGenomic studiesExpression studiesLymphoblastoid cell linesGenetic variantsCell linesExpression valuesNetwork analysisSignificant overlapGenesTranscriptsRNAASD studiesAutism spectrum disorderMale samplesLarge numberSignaturesFemales