Gene networks specific for innate immunity define post-traumatic stress disorder
Breen MS, Maihofer AX, Glatt SJ, Tylee DS, Chandler SD, Tsuang MT, Risbrough VB, Baker DG, O'Connor DT, Nievergelt CM, Woelk CH. Gene networks specific for innate immunity define post-traumatic stress disorder. Molecular Psychiatry 2015, 20: 1538-1545. PMID: 25754082, PMCID: PMC4565790, DOI: 10.1038/mp.2015.9.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderPTSD developmentStress disorderExpression of genesDevelopment of PTSDEarly preventative measuresPeripheral blood leukocytesInnate immune responseProper wound healingProspective experimental designClinical indicatorsRNA-seq gene expressionHemostatic systemBlood leukocytesInnate immuneCausal pathophysiologyMechanisms of PTSDCo-regulated genesInnate immunityPrevious transcriptomic studiesTrauma exposureCo-expression modulesU.S. MarinesPreventative measuresWound healing