Transcriptome-wide mega-analyses reveal joint dysregulation of immunologic genes and transcription regulators in brain and blood in schizophrenia
Hess JL, Tylee DS, Barve R, de Jong S, Ophoff RA, Kumarasinghe N, Tooney P, Schall U, Gardiner E, Beveridge NJ, Scott RJ, Yasawardene S, Perera A, Mendis J, Carr V, Kelly B, Cairns M, Unit T, Tsuang MT, Glatt SJ. Transcriptome-wide mega-analyses reveal joint dysregulation of immunologic genes and transcription regulators in brain and blood in schizophrenia. Schizophrenia Research 2016, 176: 114-124. PMID: 27450777, PMCID: PMC5026943, DOI: 10.1016/j.schres.2016.07.006.Peer-Reviewed Original ResearchConceptsGene co-expression modulesMicroarray dataCo-expression modulesInnate immune gene expressionRelated gene setsImmune gene expressionTranscription regulatorsNetwork-based analysisGene setsBiological functionsGene expressionRegulatory factorsPostmortem prefrontal cortexMicroarray technologyCell typesTop hitsHigh-throughput assessmentGenesTissue functionBlood tissuePostmortem brain tissueGenetic risk factorsImmunologic genesMicroarray literatureDysregulation