2014
Blood-based gene-expression biomarkers of post-traumatic stress disorder among deployed marines: A pilot study
Tylee DS, Chandler SD, Nievergelt CM, Liu X, Pazol J, Woelk CH, Lohr JB, Kremen WS, Investigators M, Baker D, Glatt S, Tsuang M. Blood-based gene-expression biomarkers of post-traumatic stress disorder among deployed marines: A pilot study. Psychoneuroendocrinology 2014, 51: 472-494. PMID: 25311155, PMCID: PMC4199086, DOI: 10.1016/j.psyneuen.2014.09.024.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderPeripheral bloodBiomarker panelStress disorderPilot studyPeripheral blood biomarkersHigh-risk individualsPeripheral blood samplesPeripheral blood cellsExpression levelsDiagnostic biomarker panelGene expression levelsTrauma-exposed individualsBlood biomarkersBlood samplesGene expression biomarkersBiomarker profilesDiagnostic utilityBrain tissueDiagnostic panelBlood cellsBloodFull-length gene transcriptsBiomarkersDisorders
2013
On the outside, looking in: A review and evaluation of the comparability of blood and brain “‐omes”
Tylee DS, Kawaguchi DM, Glatt SJ. On the outside, looking in: A review and evaluation of the comparability of blood and brain “‐omes”. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2013, 162: 595-603. PMID: 24132893, DOI: 10.1002/ajmg.b.32150.Peer-Reviewed Original ResearchConceptsCpG island methylation levelsCross-tissue correlationBlood-based biomarker studiesTranscriptomic studiesDNA methylationOmics analysisGene expressionMethylation levelsBlood tissue samplesExpression levelsProtein expressionProfiling methodExpressionEpigenomeTranscriptomeProteomeGenesMethylationTranscriptsTissue samplesValidation of biomarkersBetter understandingCritical precursorPatternsParticular subsetBlood‐based gene‐expression predictors of PTSD risk and resilience among deployed marines: A pilot study
Glatt SJ, Tylee DS, Chandler SD, Pazol J, Nievergelt CM, Woelk CH, Baker DG, Lohr JB, Kremen WS, Litz BT, Tsuang MT, Investigators M. Blood‐based gene‐expression predictors of PTSD risk and resilience among deployed marines: A pilot study. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2013, 162: 313-326. PMID: 23650250, DOI: 10.1002/ajmg.b.32167.Peer-Reviewed Original ResearchConceptsPeripheral blood cellsPeripheral bloodBlood cellsPTSD casesHigh-risk individualsPeripheral blood samplesPanel of biomarkersExpression levelsGene expression levelsPredictive biomarker panelPredictive panelHigh riskBlood samplesBiomarker panelEarly interventionGene expression predictorsTrauma exposurePTSD riskPilot studyBloodImmune genesIndependent samplesFull-length gene transcriptsPTSDRisk