Codon‐improved Cre recombinase (iCre) expression in the mouse
Shimshek DR, Kim J, Hübner MR, Spergel DJ, Buchholz F, Casanova E, Stewart AF, Seeburg PH, Sprengel R. Codon‐improved Cre recombinase (iCre) expression in the mouse. Genesis 2002, 32: 19-26. PMID: 11835670, DOI: 10.1002/gene.10023.Peer-Reviewed Original ResearchConceptsDifferent mammalian cell linesMammalian codon usageHigh CpG contentCre activityMammalian cell linesEstrogen receptor hormoneCre fusion proteinGenetic experimentsDNA recombinationEpigenetic silencingCodon usageCoding sequenceCpG contentCre geneFunctional analysisFusion proteinCre recombinase expressionReceptor hormoneAdministration of tamoxifenRecombinase expressionCre recombinaseTemporal controlICreCre expressionCell lines