A combined phase I/II trial of intravesical nanoparticle albumin-bound paclitaxel in the treatment of refractory non–muscle- invasive transitional cell bladder cancer
Barlow L, Laudano M, Mann M, Desai M, Petrylak D, Benson M, McKiernan J. A combined phase I/II trial of intravesical nanoparticle albumin-bound paclitaxel in the treatment of refractory non–muscle- invasive transitional cell bladder cancer. Journal Of Clinical Oncology 2009, 27: e16047-e16047. DOI: 10.1200/jco.2009.27.15_suppl.e16047.Peer-Reviewed Original ResearchPhase I trialPhase I/II trialIntravesical agentsNab-paclitaxelI trialII trialIntravesical therapyBladder cancerSystemic absorptionInvasive transitional cell bladder cancerResponse ratePhase II efficacy studyTis transitional cell carcinomaNanoparticle albumin-bound paclitaxelTransitional cell bladder cancerOngoing phase I trialDose-escalation modelDose-escalation trialEvidence of diseaseGrade 1 toxicityHigh-risk patientsHigh-grade TaInvasive bladder cancerAlbumin-bound paclitaxelTransitional cell carcinoma