2008
Papillomavirus Transformation
Johung K, DiMaio D. Papillomavirus Transformation. 2008, 105-126. DOI: 10.1007/978-0-387-68945-6_5.Peer-Reviewed Original ResearchNuclear tumor suppressor proteinsSmall DNA tumor virusesCell cycle controlTumor suppressor proteinCell membrane proteinsDNA tumor virusesMembrane proteinsSignal transductionGrowth factor receptorSuppressor proteinRetinoblastoma proteinCycle controlE5 geneViral oncogenesOncogenic potentialTumor virusFactor receptorProteinGenesE7 genesHuman papillomavirus infectionPrevalent malignant tumorMalignant epithelial tumorsImportant insightsPapillomavirus infection
1993
Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene
Hwang E, Riese D, Settleman J, Nilson L, Honig J, Flynn S, DiMaio D. Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene. Journal Of Virology 1993, 67: 3720-3729. PMID: 8389903, PMCID: PMC237735, DOI: 10.1128/jvi.67.7.3720-3729.1993.Peer-Reviewed Original ResearchConceptsBPV E2 proteinGene expressionCervical carcinoma cell linesRegulatory genesHPV gene expressionCarcinoma cell linesCell linesE2 proteinHeLa cellsConsequence of abrogationP53 tumor suppressor proteinHPV18 E6Tumor suppressor proteinE2 geneDestabilization of p53HT-3 cellsGrowth inhibitionBPV E2Simian virus 40Suppressor proteinEpithelial cell lineHuman papillomavirus E6Cell cycleGenesS phase
1992
The putative E5 open reading frame of cottontail rabbit papillomavirus is dispensable for papilloma formation in domestic rabbits
Brandsma J, Yang Z, DiMaio D, Barthold S, Johnson E, Xiao W. The putative E5 open reading frame of cottontail rabbit papillomavirus is dispensable for papilloma formation in domestic rabbits. Journal Of Virology 1992, 66: 6204-6207. PMID: 1326666, PMCID: PMC283673, DOI: 10.1128/jvi.66.10.6204-6207.1992.Peer-Reviewed Original ResearchConceptsE5 ORFCRPV DNACRPV genomeCottontail rabbit papillomavirusE5 mutantsFrameshift mutantsBiological functionsORFRabbit papillomavirusMutantsMutant DNATransition mutationsPapilloma formationDNA preparationsDNABiochemical analysisGenomeE5 regionDomestic rabbitsFrame mutationsMutationsCodonGenesInduction of papillomasFrameshift
1991
Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16
Leptak C, Cajal S, Kulke R, Horwitz B, Riese D, Dotto G, DiMaio D. Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16. Journal Of Virology 1991, 65: 7078-7083. PMID: 1658398, PMCID: PMC250837, DOI: 10.1128/jvi.65.12.7078-7083.1991.Peer-Reviewed Original ResearchConceptsBovine papillomavirus type 1E5 genePapillomavirus type 1Human Papillomavirus Type 16 E5 GeneTumorigenic transformationHost epithelial cellsExpression vectorRecombinant virusesRetroviral expression vectorMurine keratinocytesBiological propertiesTumorigenic cellsMurine epidermal keratinocytesGenesMurine fibroblastsFrameshift mutationCultured linesHuman papillomavirus type 16Cell linesEpithelial cellsPapillomavirus type 16Epidermal keratinocytesRetrovirusesCellsKeratinocytesTransforming Activity of Bovine and Human Papillomaviruses in Cultured Cells
DiMaio D. Transforming Activity of Bovine and Human Papillomaviruses in Cultured Cells. Advances In Cancer Research 1991, 56: 133-159. PMID: 1851373, DOI: 10.1016/s0065-230x(08)60480-7.Peer-Reviewed Original ResearchConceptsBovine papillomavirus type ICultured cellsTransient expression systemViral gene productsGene productsComplex phenotypesExpression systemTumorigenic transformationBiochemical eventsMolecular descriptionCell morphologyCottontail rabbit papillomavirusBiological responsesHuman carcinomasCultured fibroblastsGrowth propertiesCellsRabbit papillomavirusHomogeneous populationProfound effectGenesType ISimilar activityTumorigenesisPhenotype
1989
Genetic evidence that acute morphologic transformation, induction of cellular DNA synthesis, and focus formation are mediated by a single activity of the bovine papillomavirus E5 protein.
Settleman J, Fazeli A, Malicki J, Horwitz B, DiMaio D. Genetic evidence that acute morphologic transformation, induction of cellular DNA synthesis, and focus formation are mediated by a single activity of the bovine papillomavirus E5 protein. Molecular And Cellular Biology 1989, 9: 5563-5572. PMID: 2555701, PMCID: PMC363726, DOI: 10.1128/mcb.9.12.5563.Peer-Reviewed Original ResearchConceptsE5 proteinE5 geneCellular DNA synthesisC127 cellsBovine papillomavirus E5 proteinMouse C127 cellsDNA synthesisMorphologic transformationCultured rodent cellsDefective phenotypeMissense mutantsUnstable proteinDefective mutantsGenetic evidenceMutational analysisE5 activityRodent cellsCell cycleViral genesBiochemical activitySerum starvationCell transformationGenesContact inhibitionVirus multiplicityGenetic Evidence that Acute Morphologic Transformation, Induction of Cellular DNA Synthesis, and Focus Formation Are Mediated by a Single Activity of the Bovine Papillomavirus E5 Protein
Settleman J, Fazeli A, Malicki J, Horwitz B, Dimaio D. Genetic Evidence that Acute Morphologic Transformation, Induction of Cellular DNA Synthesis, and Focus Formation Are Mediated by a Single Activity of the Bovine Papillomavirus E5 Protein. Molecular And Cellular Biology 1989, 9: 5563-5572. DOI: 10.1128/mcb.9.12.5563-5572.1989.Peer-Reviewed Original ResearchE5 proteinE5 geneCellular DNA synthesisC127 cellsBovine papillomavirus E5 proteinMouse C127 cellsDNA synthesisMorphologic transformationCultured rodent cellsDefective phenotypeMissense mutantsUnstable proteinDefective mutantsGenetic evidenceMutational analysisE5 activityRodent cellsCell cycleViral genesBiochemical activitySerum starvationFoci formationCell transformationGenesContact inhibitionStructure, Activity, and Regulation of the Bovine Papillomavirus E5 Gene and Its Transforming Protein Product
Horwitz B, Settleman J, Prakash S, DiMaio D. Structure, Activity, and Regulation of the Bovine Papillomavirus E5 Gene and Its Transforming Protein Product. Current Topics In Microbiology And Immunology 1989, 144: 143-151. PMID: 2551579, DOI: 10.1007/978-3-642-74578-2_18.Peer-Reviewed Original ResearchConceptsE5 geneFoci formationBovine papillomavirus type 1 DNACell focus formationBPV geneCodon resultsC127 cellsMouse cellsTumorigenic transformationProtein productsK polypeptideGenesViral mutantsBiochemical analysisEfficient transformationCellsMutantsPolypeptideDNARegulationExpressionDownstreamActivityTranslationFormation
1987
Stimulation of cellular DNA synthesis by wild type and mutant bovine papillomavirus DNA
Jaskulski D, Kaczmarek L, DiMaio D. Stimulation of cellular DNA synthesis by wild type and mutant bovine papillomavirus DNA. Biochemical And Biophysical Research Communications 1987, 148: 86-91. PMID: 2823817, DOI: 10.1016/0006-291x(87)91079-5.Peer-Reviewed Original ResearchPapillomavirus Cloning Vectors
DiMaio D. Papillomavirus Cloning Vectors. The Viruses 1987, 293-319. DOI: 10.1007/978-1-4757-0584-3_11.Peer-Reviewed Original Research
1983
Identification of two distinct regulatory regions adjacent to the human β-interferon gene
Zinn K, Dimaio D, Maniatis T. Identification of two distinct regulatory regions adjacent to the human β-interferon gene. Cell 1983, 34: 865-879. PMID: 6313211, DOI: 10.1016/0092-8674(83)90544-5.Peer-Reviewed Original ResearchConceptsIFN gene expressionBovine papilloma virusRegulatory regionsExpression of deletion mutantsGene expressionMRNA cap sitePoly(I)-poly(CCell linesStable cell linesIndependent cell linesCloned geneStructural geneDeletion mutantsLevel of expressionKinetics of inductionCap siteMouse cellsHuman beta-interferonGenesInduced expressionConstitutive levelsDeletionBeta-interferonExpressionPapilloma virus