A Nuclear Magnetic Resonance Investigation of the Energetics of Basepair Opening Pathways in DNA
Coman D, Russu IM. A Nuclear Magnetic Resonance Investigation of the Energetics of Basepair Opening Pathways in DNA. Biophysical Journal 2005, 89: 3285-3292. PMID: 16126830, PMCID: PMC1366824, DOI: 10.1529/biophysj.105.065763.Peer-Reviewed Original ResearchConceptsOpening reactionFree energyNuclear magnetic resonance investigationFree energy relationshipsMagnetic resonance investigationNMR spectroscopySolvent protonsProton exchangeEnergy relationshipsTransition stateExchange catalystResonance investigationOpening pathwaysRate of exchangeEquilibrium constantsEnthalpy changeDNA duplexImino protonsReactionNeighboring basesProtonsDifferent temperaturesEnergeticsOpen stateCatalystBase Pair Opening in Three DNA-unwinding Elements*
Coman D, Russu IM. Base Pair Opening in Three DNA-unwinding Elements*. Journal Of Biological Chemistry 2005, 280: 20216-20221. PMID: 15784615, DOI: 10.1074/jbc.m502773200.Peer-Reviewed Original ResearchConceptsDNA-unwinding elementsBase pairsDNA replicationIndividual base pairsBase sequenceEscherichia coli chromosomeOrigin of replicationTA base pairsSpecific base sequencesColi chromosomeBacterial genomesBacterial chromosomeDNA double helixDNA moleculesStrand separationFirst characterizationChromosomesStart pointBase pair openingDouble helixDNAReplicationSequenceNuclear magnetic resonance spectroscopyLong-range effects