2020
Corrigendum: Core Neuropsychological Measures for Obesity and Diabetes Trials: Initial Report
D'Ardenne K, Savage CR, Small D, Vainik U, Stoeckel LE. Corrigendum: Core Neuropsychological Measures for Obesity and Diabetes Trials: Initial Report. Frontiers In Psychology 2020, 11: 612441. PMID: 33240187, PMCID: PMC7680884, DOI: 10.3389/fpsyg.2020.612441.Peer-Reviewed Original ResearchCore Neuropsychological Measures for Obesity and Diabetes Trials: Initial Report
D’Ardenne K, Savage CR, Small D, Vainik U, Stoeckel LE. Core Neuropsychological Measures for Obesity and Diabetes Trials: Initial Report. Frontiers In Psychology 2020, 11: 554127. PMID: 33117225, PMCID: PMC7557362, DOI: 10.3389/fpsyg.2020.554127.Peer-Reviewed Original ResearchIdentification of a brain fingerprint for overweight and obesity
Farruggia MC, van Kooten MJ, Perszyk EE, Burke MV, Scheinost D, Constable RT, Small DM. Identification of a brain fingerprint for overweight and obesity. Physiology & Behavior 2020, 222: 112940. PMID: 32417645, PMCID: PMC7321926, DOI: 10.1016/j.physbeh.2020.112940.Peer-Reviewed Original ResearchConceptsPercent body fatWaist circumferenceBody fatWhole-brain functional connectivityBrain network patternsGlucose toleranceBlood insulinObesityOverweightPathophysiological phenotypesFunctional connectivity networksFunctional connectivityMilkshake consumptionBrain correlatesBrain fingerprintsBMIAdiposityBrainCircumferenceConnectivity networksFatDiabetesPathophysiologyCentral roleInsulinShort-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans
Dalenberg JR, Patel BP, Denis R, Veldhuizen MG, Nakamura Y, Vinke PC, Luquet S, Small DM. Short-Term Consumption of Sucralose with, but Not without, Carbohydrate Impairs Neural and Metabolic Sensitivity to Sugar in Humans. Cell Metabolism 2020, 31: 493-502.e7. PMID: 32130881, PMCID: PMC7784207, DOI: 10.1016/j.cmet.2020.01.014.Peer-Reviewed Original ResearchConceptsGlucose metabolismPrevalence of obesityType 2 diabetesSugar-sweetened beveragesConsumption of sucraloseHealthy human participantsInsulin sensitivityTerm consumptionTaste perceptionMetabolismLong-term decreaseSweet tasteMetabolic sensitivityComorbiditiesGeneral consensusObesityDiabetesHuman participantsBeveragesMidbrainPrevalenceBrainSimilar relationship
2019
Processed foods and food reward
Small DM, DiFeliceantonio AG. Processed foods and food reward. Science 2019, 363: 346-347. PMID: 30679360, DOI: 10.1126/science.aav0556.Peer-Reviewed Original Research
2018
Chapter 7 Diet, Obesity, and Physical Inactivity Linking Diabetes and Dementia
Espeland M, Small D, Stoeckel L. Chapter 7 Diet, Obesity, and Physical Inactivity Linking Diabetes and Dementia. 2018, 117-141. DOI: 10.1016/b978-0-12-809454-9.00007-x.Peer-Reviewed Original ResearchRisk factorsMetabolic dysfunctionModifiable risk factorsDevelopment of dementiaComplex multifactorial interactionPhysical inactivityCognitive dysfunctionNeurocognitive dysfunctionPhysical activityNeurocognitive impairmentObesityDysfunctionDiabetesDementiaMultifactorial interactionsDietFactorsImpairment
2017
DRD2: Bridging the Genome and Ingestive Behavior
Sun X, Luquet S, Small DM. DRD2: Bridging the Genome and Ingestive Behavior. Trends In Cognitive Sciences 2017, 21: 372-384. PMID: 28372879, PMCID: PMC5745142, DOI: 10.1016/j.tics.2017.03.004.Peer-Reviewed Original ResearchConceptsGenetic variantsCommon gene variantsMetabolic dysfunctionNeurocognitive impairmentAppetitive functionsDA signalingCognitive declinePolygenic obesityBrain structures× environment interactionGene variantsConfer riskIngestive behaviorGene × environment interactionsNeurotransmitter dopamineObesityCognitive changesDopamineMetabolic signalsEnvironment interactionPivotal roleRiskSignalingFeedingDysfunctionDopamine Adaptations as a Common Pathway for Neurocognitive Impairment in Diabetes and Obesity: A Neuropsychological Perspective
Small DM. Dopamine Adaptations as a Common Pathway for Neurocognitive Impairment in Diabetes and Obesity: A Neuropsychological Perspective. Frontiers In Neuroscience 2017, 11: 134. PMID: 28400713, PMCID: PMC5368264, DOI: 10.3389/fnins.2017.00134.Peer-Reviewed Original Research
2016
Reorganization of brain connectivity in obesity
Geha P, Cecchi G, Constable R, Abdallah C, Small DM. Reorganization of brain connectivity in obesity. Human Brain Mapping 2016, 38: 1403-1420. PMID: 27859973, PMCID: PMC6866793, DOI: 10.1002/hbm.23462.Peer-Reviewed Original ResearchConceptsGlobal brain connectivityDorsal attention networkPeripheral metabolic dysfunctionHum Brain MappSuperior parietal lobuleSomatomotor cortexMetabolic dysfunctionVentrolateral prefrontal cortexPremotor areasCaudate nucleusNeurocognitive impairmentObesityAnterior hippocampusVisual cortexBrain regionsParietal lobuleBrain functionPrefrontal cortexBrain connectivityMilkshake consumptionCortexFeeding decisionsBrain organizationInsulaHomeostatic state
2013
Decreased food pleasure and disrupted satiety signals in chronic low back pain
Geha P, deAraujo I, Green B, Small DM. Decreased food pleasure and disrupted satiety signals in chronic low back pain. Pain 2013, 155: 712-722. PMID: 24384160, DOI: 10.1016/j.pain.2013.12.027.Peer-Reviewed Original ResearchConceptsChronic low back painCLBP patientsLow back painHealthy controlsBack painSugary drinksFat calorie intakeHedonic perceptionSatiety signalsCalorie intakePatientsIntake testFood pleasureFunctional brainAd libitumPotential mechanismsPainObesityIntakeStructural alterationsPhysiological mechanismsHedonic ratingsAlterationsDrinksSensory evaluation
2011
Youth at Risk for Obesity Show Greater Activation of Striatal and Somatosensory Regions to Food
Stice E, Yokum S, Burger KS, Epstein LH, Small DM. Youth at Risk for Obesity Show Greater Activation of Striatal and Somatosensory Regions to Food. Journal Of Neuroscience 2011, 31: 4360-4366. PMID: 21430137, PMCID: PMC3260083, DOI: 10.1523/jneurosci.6604-10.2011.Peer-Reviewed Original ResearchConceptsNormal weight humansObese humansStriatal responsesFood intakeOrbitofrontal cortexDopamine signalingWeight gainInitial vulnerability factorsGenetic riskStriatal D2 receptorsMonetary rewardsNormal-weight adolescentsPalatable food intakeD2 receptor densityD2 receptorsHigh-risk youthParietal operculumReceptor densitySomatosensory regionsPalatable foodFoods contributesFrontal operculumReward circuitryReduced dopamineObesity
2008
Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele
Stice E, Spoor S, Bohon C, Small DM. Relation Between Obesity and Blunted Striatal Response to Food Is Moderated by TaqIA A1 Allele. Science 2008, 322: 449-452. PMID: 18927395, PMCID: PMC2681095, DOI: 10.1126/science.1161550.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAllelesBasal GangliaBody Mass IndexCaudate NucleusCorpus StriatumCuesDeoxyribonucleases, Type II Site-SpecificDopamineEatingFemaleFoodHumansHyperphagiaMagnetic Resonance ImagingObesityPolymorphism, Restriction Fragment LengthPutamenReceptors, Dopamine D2Regression AnalysisRewardSignal TransductionWeight GainConceptsDorsal striatumTaqIA restriction fragment length polymorphismConsummatory food rewardMagnetic resonance imaging studyStriatal dopamine receptorsDevelopment of obesityA1 alleleResonance imaging studyFunctional magnetic resonance imaging studyDopamine D2 receptor geneTaqIA A1 alleleObese individualsStriatal dopamineD2 receptor geneProspective dataLean individualsDopamine receptorsFood intakeStriatumImaging studiesStriatal responsesStriatal activationGenetic polymorphismsReceptor geneObesity