Restriction of viral replication, rather than T cell immunopathology, drives lethality in MNV CR6-infected STAT1-deficient mice
Sharon A, Filyk H, Fonseca N, Simister R, Filler R, Yuen W, Hardman B, Robinson H, Seo J, Rocha-Pereira J, Welch I, Neyts J, Wilen C, Crowe S, Osborne L. Restriction of viral replication, rather than T cell immunopathology, drives lethality in MNV CR6-infected STAT1-deficient mice. The Journal Of Immunology 2022, 208: 182.04-182.04. DOI: 10.4049/jimmunol.208.supp.182.04.Peer-Reviewed Original ResearchAntiviral T cell responsesT cell responsesSTAT1-deficient miceCell responsesViral replicationViral infectionViral-induced tissue damageC57BL6/J miceAdaptive immune populationsLimited viral replicationT cell immunopathologyAdaptive immune cellsUncontrolled viral replicationHigh viral loadHost-directed mechanismKey innateLethal immunopathologyInfectious insultsViral loadImmune populationsImmune cellsJ miceTherapeutic administrationIntestinal homeostasisIntestinal mucosa