2017
Who achieves low risk drinking during alcohol treatment? An analysis of patients in three alcohol clinical trials
Witkiewitz K, Pearson MR, Hallgren KA, Maisto SA, Roos CR, Kirouac M, Wilson AD, Montes KS, Heather N. Who achieves low risk drinking during alcohol treatment? An analysis of patients in three alcohol clinical trials. Addiction 2017, 112: 2112-2121. PMID: 28511286, PMCID: PMC5673549, DOI: 10.1111/add.13870.Peer-Reviewed Original ResearchConceptsLow-risk drinkingPatterns of drinkingHeavy drinkingAlcohol dependenceSelf-reported weekly alcohol consumptionDrinking patternsPersistent heavy drinkingRepeated-measures latent class analysisWeekly alcohol consumptionAlcohol clinical trialsBehavioral intervention studyAlcohol Treatment TrialUnited Kingdom Alcohol Treatment TrialTreatment trialsCombined PharmacotherapiesClinical trialsAverage ageAlcohol consumptionAlcohol dependence severityIntervention studiesAlcohol treatmentCollateral informantsForm 90Dependence severityLatent class analysis
2016
Reward and relief dimensions of temptation to drink: construct validity and role in predicting differential benefit from acamprosate and naltrexone
Roos CR, Mann K, Witkiewitz K. Reward and relief dimensions of temptation to drink: construct validity and role in predicting differential benefit from acamprosate and naltrexone. Addiction Biology 2016, 22: 1528-1539. PMID: 27480445, PMCID: PMC5290305, DOI: 10.1111/adb.12427.Peer-Reviewed Original ResearchConceptsAlcohol use disorderTreatment of AUDOpioid receptor antagonistRandomized clinical trialsBetter drinking outcomesGlutamatergic systemSubtypes of individualsReceptor antagonistClinical trialsRewarding effectsUse disordersClinical decisionDrinking outcomesReward drinkersDrinkersNaltrexoneExcellent reliabilityDifferential benefitsDistinct patterns