2018
Impaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations
Gomez JL, Diaz MP, Nino G, Britto CJ. Impaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations. BMC Medical Genomics 2018, 11: 21. PMID: 29486764, PMCID: PMC5830339, DOI: 10.1186/s12920-018-0340-3.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsAsthma exacerbationsInterferon-stimulated genesRespiratory infectionsIL-15Vivo cohortToll-like receptor 2STAT1 responseRecurrent asthma exacerbationsAcute asthma exacerbationPro-inflammatory moleculesType I interferon regulationBlood mononuclear cellsPro-inflammatory signatureTranscriptomic signaturesType I interferonFold changeAdult asthmaAcute phaseMononuclear cellsImmunologic genesExacerbationIndependent cohortReceptor 2I interferon
2016
Respiratory Viral Infections in Chronic Lung Diseases
Britto CJ, Brady V, Lee S, Dela Cruz CS. Respiratory Viral Infections in Chronic Lung Diseases. Clinics In Chest Medicine 2016, 38: 87-96. PMID: 28159164, PMCID: PMC5679206, DOI: 10.1016/j.ccm.2016.11.014.Peer-Reviewed Original ResearchConceptsChronic lung diseaseChronic obstructive pulmonary diseaseInterstitial lung diseaseLung diseaseLung infectionViral infectionCystic fibrosisRespiratory viral infectionsObstructive pulmonary diseaseDifferent lung diseasesDisease exacerbationPulmonary diseaseDisease pathogenesisInfectionDiseaseAsthmaExacerbationPatientsFibrosisPathogenesisProgression