Genetic Determinants of Phosphate Response in Drosophila
Bergwitz C, Wee MJ, Sinha S, Huang J, DeRobertis C, Mensah LB, Cohen J, Friedman A, Kulkarni M, Hu Y, Vinayagam A, Schnall-Levin M, Berger B, Perkins LA, Mohr SE, Perrimon N. Genetic Determinants of Phosphate Response in Drosophila. PLOS ONE 2013, 8: e56753. PMID: 23520455, PMCID: PMC3592877, DOI: 10.1371/journal.pone.0056753.Peer-Reviewed Original ResearchConceptsLarval developmentGenome-wide RNAi screenDrosophila larval developmentGenetic determinantsImportant cellular processesNovel genetic determinantsAdult life spanLife spanExtracellular phosphate levelsD-rafRNAi-mediated inhibitionRNAi screenDrosophila melanogasterPhosphate responseCellular processesResponse to phosphateAdult fliesCandidate genesLive fliesMAPK activationAvailability of phosphateCellular responsesHigh phosphate mediumMalpighian tubulesReduced life span