2021
Phosphorus bioaccessibility measured in four amino acid–based formulas using in-vitro batch digestion translates well into phosphorus bioavailability in mice
Chande S, Dijk F, Fetene J, Yannicelli S, Carpenter TO, van Helvoort A, Bergwitz C. Phosphorus bioaccessibility measured in four amino acid–based formulas using in-vitro batch digestion translates well into phosphorus bioavailability in mice. Nutrition 2021, 89: 111291. PMID: 34111672, PMCID: PMC8588148, DOI: 10.1016/j.nut.2021.111291.Peer-Reviewed Original ResearchConceptsPhosphorus bioavailabilityAmino acid-based formulaProton pump inhibitorsDigestion modelBioavailability analysisPlasma phosphorus levelsLow phosphorus dietDigestion conditionsBioaccessibilityBioavailabilityStomach acidificationDigestive conditionsIntact fibroblast growth factor 23Phosphorus dietFibroblast growth factor 23Stomach pH.Intact parathyroid hormoneAcid-suppressive medicationsDihydroxy vitamin DGrowth factor 23Phosphorus levelsPhosphorus bioaccessibilityAcidificationPhosphorusIntact fibroblast growth factor
2020
Different elemental infant formulas show equivalent phosphorus and calcium bioavailability in healthy volunteers
Bergwitz C, Eussen SRBM, Janssens PLHR, Visser M, Carpenter TO, van Helvoort A. Different elemental infant formulas show equivalent phosphorus and calcium bioavailability in healthy volunteers. Nutrition Research 2020, 85: 71-83. PMID: 33450668, DOI: 10.1016/j.nutres.2020.11.004.Peer-Reviewed Original ResearchConceptsGeometric mean ratiosAcid-suppressive medicationsArea under the curveHealthy volunteersSerum phosphateCalcium bioavailabilityGastric acid-suppressive medicationsRetrospective chart reviewSerum calcium concentrationBioavailability of phosphorusCross-over studyInfant formulaElemental formula useSingle oral doseCalcium excretionDouble-blindGram of phosphorusSingle-centerChart reviewOral doseOvernight fastingSerum phosphorusBioequivalence criteriaWashout periodMean ratiosImportance of Dietary Phosphorus for Bone Metabolism and Healthy Aging
Serna J, Bergwitz C. Importance of Dietary Phosphorus for Bone Metabolism and Healthy Aging. Nutrients 2020, 12: 3001. PMID: 33007883, PMCID: PMC7599912, DOI: 10.3390/nu12103001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDietary phosphorusReduced bioavailabilityHealthy agingHigh dietary phosphorusSources of dietary phosphorusReduced longevityAbundance of phosphorusBone metabolismWestern dietPhosphorusTissue calcificationMetabolic changesEndocrine regulationBioavailabilityNormal amountsTissueCurrent knowledgeAbundanceDifferent tissuesExcessive lossOsteomalacia