Membrane attack complexes, endothelial cell activation, and direct allorecognition
Song G, Wang S, Barkestani MN, Mullan C, Fan M, Jiang B, Jiang Q, Li X, Jane-wit D. Membrane attack complexes, endothelial cell activation, and direct allorecognition. Frontiers In Immunology 2022, 13: 1020889. PMID: 36211400, PMCID: PMC9539657, DOI: 10.3389/fimmu.2022.1020889.Peer-Reviewed Original ResearchConceptsAntibody-mediated rejectionIschemia-reperfusion injuryDonor-derived endothelial cellsAlloreactive T cellsT cellsDirect allorecognitionInflammatory mediatorsMembrane attack complexEndothelial cellsTissue allograftsCell activationEC activationComplement cascadeAlloimmune T cell responsesT cell-mediated inflammationSolid organ transplant rejectionCell-mediated inflammationRecipient T cellsSolid organ transplantationT cell infiltrationT cell responsesDonor endothelial cellsImmune cell activationEndothelial cell activationOrgan transplant rejection