2022
Cryo-EM structures of prefusion SIV envelope trimer
Gorman J, Wang C, Mason R, Nazzari A, Welles H, Zhou T, Bess J, Bylund T, Lee M, Tsybovsky Y, Verardi R, Wang S, Yang Y, Zhang B, Rawi R, Keele B, Lifson J, Liu J, Roederer M, Kwong P. Cryo-EM structures of prefusion SIV envelope trimer. Nature Structural & Molecular Biology 2022, 29: 1080-1091. PMID: 36344847, DOI: 10.1038/s41594-022-00852-1.Peer-Reviewed Original Research
2019
Structural dynamics of bacteriophage P22 infection initiation revealed by cryo-electron tomography
Wang C, Tu J, Liu J, Molineux IJ. Structural dynamics of bacteriophage P22 infection initiation revealed by cryo-electron tomography. Nature Microbiology 2019, 4: 1049-1056. PMID: 30886360, PMCID: PMC6533119, DOI: 10.1038/s41564-019-0403-z.Peer-Reviewed Original ResearchConceptsCryo-electron tomographyOuter membraneInfection initiationCell surfaceBacterial cell envelopeSalmonella enterica serovar TyphimuriumGenome translocationGram-negative bacteriaEnterica serovar TyphimuriumTail needleCytoplasmic membraneSecond proteinExtracellular channelsCell envelopePhage P22Successful infectionCell cytoplasmSerovar TyphimuriumSuch virionsGenomeCytoplasmProteinO-antigenPhagesAssembles
2015
Morphogenesis of Endoplasmic Reticulum Membrane-Invaginated Vesicles during Beet Black Scorch Virus Infection: Role of Auxiliary Replication Protein and New Implications of Three-Dimensional Architecture
Cao X, Jin X, Zhang X, Li Y, Wang C, Wang X, Hong J, Wang X, Li D, Zhang Y. Morphogenesis of Endoplasmic Reticulum Membrane-Invaginated Vesicles during Beet Black Scorch Virus Infection: Role of Auxiliary Replication Protein and New Implications of Three-Dimensional Architecture. Journal Of Virology 2015, 89: 6184-6195. PMID: 25833056, PMCID: PMC4474299, DOI: 10.1128/jvi.00401-15.Peer-Reviewed Original ResearchMeSH KeywordsElectron Microscope TomographyEndoplasmic ReticulumHost-Pathogen InteractionsMicroscopy, ImmunoelectronTobaccoTombusviridaeViral ProteinsVirus ReplicationConceptsMembrane-bound viral replication complexVirus replication complexesViral replication complexPositive-strand RNA virusesElectron tomographic analysisEndoplasmic reticulum membraneReplication complexVesicle packetsRNA virusesProtein p23Reticulum membraneNicotiana benthamiana cellsBlack scorch virusHost intracellular membranesDouble-stranded RNAProgeny viral RNAPositive-strand RNAThree-dimensional architectureViral replication intermediatesN. benthamianaFamily TombusviridaeReplication proteinsER membraneP23 proteinIntracellular membranes