2016
Chondro-protective effects of low intensity pulsed ultrasound
Uddin S, Richbourgh B, Ding Y, Hettinghouse A, Komatsu D, Qin Y, Liu C. Chondro-protective effects of low intensity pulsed ultrasound. Osteoarthritis And Cartilage 2016, 24: 1989-1998. PMID: 27364595, PMCID: PMC5071131, DOI: 10.1016/j.joca.2016.06.014.Peer-Reviewed Original ResearchConceptsIL-1βHuman cartilage explantsCartilage degradationMesenchymal stem cellsIL-1β induced activationPotential therapeutic effectsChondro-protective effectsPathogenesis of osteoarthritisLIPUS stimulationCartilage explantsChondrocyte migrationWestern blot analysisLoss of proteoglycanTherapeutic effectNFκB p65Catabolic actionMetabolic alterationsNFκB pathwayOsteoarthritisReduced expressionChondrocyte metabolismInduced activationMechanical stimulationLIPUSStimulation
2008
Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin
Luan Y, Kong L, Howell D, Ilalov K, Fajardo M, Bai X, Di Cesare P, Goldring M, Abramson S, Liu C. Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. Osteoarthritis And Cartilage 2008, 16: 1413-1420. PMID: 18485748, PMCID: PMC2574789, DOI: 10.1016/j.joca.2008.03.017.Peer-Reviewed Original ResearchConceptsCartilage oligomeric matrix proteinADAMTS-7ADAMTS-12COMP degradationOA patientsOligomeric matrix proteinIL-1betaTNF-alphaHuman chondrocytesCartilage explantsCultured cartilage explantsFirst endogenous inhibitorsArthritic patientsTumor necrosisMatrix proteinsCOMP fragmentsPatientsEndogenous inhibitorDependent mannerOsteoarthritisADAMTS familyAntibodiesInhibitionCartilageChondrocytes