2020
The use of 4F‐PCC to correct direct oral anticoagulant‐induced coagulopathy: An observational analysis
Zheng Y, Tormey CA. The use of 4F‐PCC to correct direct oral anticoagulant‐induced coagulopathy: An observational analysis. Transfusion Medicine 2020, 30: 304-307. PMID: 32342588, DOI: 10.1111/tme.12683.Peer-Reviewed Original ResearchConceptsDirect oral anticoagulantsThromboembolic eventsFour-factor prothrombin complex concentrateLevel 1 trauma centerAdditional prospective studiesRetrospective observational studyProthrombin complex concentrateOff-label useEmergent surgeryOral anticoagulantsMost patientsClinical outcomesTrauma centerHgb levelsProspective studyLabel indicationsComplex concentrateSevere hemorrhageObservational studyHemorrhage sizePatientsCoagulopathyAdministrationBleedingHemorrhage
2015
Novel Oral Anticoagulants: Efficacy, Laboratory Measurement, and Approaches to Emergent Reversal
Gehrie E, Tormey C. Novel Oral Anticoagulants: Efficacy, Laboratory Measurement, and Approaches to Emergent Reversal. Archives Of Pathology & Laboratory Medicine 2015, 139: 687-92. PMID: 25927153, DOI: 10.5858/arpa.2013-0677-rs.Peer-Reviewed Original ResearchConceptsNovel oral anticoagulantsManagement of NOACOral direct thrombin inhibitorDirect factor Xa inhibitorVitamin K antagonistsDirect thrombin inhibitorFactor Xa inhibitorsCertain clinical circumstancesOral anticoagulationWarfarin effectivenessK antagonistsOral anticoagulantsClinical efficacySafety profileEmergent reversalClinical circumstancesXa inhibitorsUS FoodDrug AdministrationThrombin inhibitorsNew drugsDrugsEfficacyInhibitorsLaboratory assays
2014
Clinical Applications of 4-Factor Prothrombin Complex Concentrate: A Practical Pathologist's Perspective
Unold D, Tormey CA. Clinical Applications of 4-Factor Prothrombin Complex Concentrate: A Practical Pathologist's Perspective. Archives Of Pathology & Laboratory Medicine 2014, 139: 1568-75. PMID: 26619030, DOI: 10.5858/arpa.2014-0366-rs.Peer-Reviewed Original ResearchConceptsProthrombin complex concentrateOral anticoagulantsComplex concentrateVitamin K antagonist reversalVitamin K antagonist therapyNovel oral anticoagulantsSpecific reversal agentsTreatment of hemorrhageDependent coagulation factorsAntagonist therapyLiver diseaseLabel indicationsAntagonist reversalTherapeutic dosesReversal agentsCoagulation factorsBleeding disorderRare coagulopathyVitamin KBlood bankersPathologist's perspectiveClinical applicationAnticoagulantsCoagulopathyBleedingLupus anticoagulant testing and anticoagulation do not mix: quantitation of discrepant results and potential approaches to reduce false positives
Chandler JB, Torres R, Rinder HM, Tormey CA. Lupus anticoagulant testing and anticoagulation do not mix: quantitation of discrepant results and potential approaches to reduce false positives. British Journal Of Haematology 2014, 167: 704-707. PMID: 25041401, PMCID: PMC7024602, DOI: 10.1111/bjh.13030.Peer-Reviewed Original Research
2010
Evidence‐based practice guidelines for plasma transfusion
Roback JD, Caldwell S, Carson J, Davenport R, Drew MJ, Eder A, Fung M, Hamilton M, Hess JR, Luban N, Perkins JG, Sachais BS, Shander A, Silverman T, Snyder E, Tormey C, Waters J, Djulbegovic B. Evidence‐based practice guidelines for plasma transfusion. Transfusion 2010, 50: 1227-1239. PMID: 20345562, DOI: 10.1111/j.1537-2995.2010.02632.x.Peer-Reviewed Original ResearchMeSH KeywordsAnticoagulantsBlood Component TransfusionEvidence-Based MedicineHumansIntracranial HemorrhagesPlasmaWarfarinConceptsTransfusion of plasmaPlasma transfusionCommon clinical scenariosMassive transfusionEvidence-based guidanceSystematic reviewIntracranial hemorrhageTransfusion decisionsPractice guidelinesClinical scenariosRed blood cell ratioEvidence-based practice guidelinesMultidisciplinary guideline panelPlasma transfusion guidelinesBlood cell ratioGroup of patientsClinical practice guidelinesAppropriate transfusionTransfusion guidelinesWarfarin anticoagulationGRADE methodologyGuideline panelObservational studyTransfusionDefinitive guidelines
2009
Improved plasma removal efficiency for therapeutic plasma exchange using a new apheresis platform
Tormey CA, Peddinghaus ME, Erickson M, King KE, Cushing MM, Bill J, Goodrich T, Snyder EL. Improved plasma removal efficiency for therapeutic plasma exchange using a new apheresis platform. Transfusion 2009, 50: 471-477. PMID: 19804570, DOI: 10.1111/j.1537-2995.2009.02412.x.Peer-Reviewed Original ResearchConceptsSignificant adverse eventsCellular countsPatients D-dimerPlasma-exchange programPlasma removal efficiencyTherapeutic plasma exchangePrimary outcome measureFluid balance measurementsComplement cascade activationPatient's coagulationSecondary outcomesAdverse eventsPlasma exchangeAnticoagulant usageD-dimerClinical trialsFluid replacementOutcome measuresFluid balanceCoagulation systemCOBE Spectra platformFree hemoglobinStudy designWaste plasmaNew apheresis device