2017
The impact of vaccination on RBC alloimmunization in a murine model
Natarajan P, Santhanakrishnan M, Tormey CA, Hendrickson JE. The impact of vaccination on RBC alloimmunization in a murine model. Vox Sanguinis 2017, 112: 598-600. PMID: 28597520, PMCID: PMC5575953, DOI: 10.1111/vox.12541.Peer-Reviewed Original ResearchConceptsImmune responseMurine modelRBC alloantibody formationDamage-associated molecular patternsImpact of vaccinationRBC alloimmunizationAlloantibody formationHepB vaccineRBC transfusionAdaptive immunityAnimal modelsAlloimmunizationMolecular patternsVaccineVaccinationFuture studiesResponseTransfusionImmunity
2016
Red blood cell alloimmunization
Hendrickson JE, Eisenbarth SC, Tormey CA. Red blood cell alloimmunization. Current Opinion In Hematology 2016, 23: 543-549. PMID: 27454234, DOI: 10.1097/moh.0000000000000277.Peer-Reviewed Original ResearchConceptsAlloimmune responseChronic red blood cell transfusionsRed blood cell transfusionRed blood cell alloimmunizationHuman leukocyte antigen (HLA) expressionBlood cell transfusionT-cell markersRecent animal studiesResult of pregnancyRecipient inflammationSuch alloimmunizationCell transfusionDendritic cellsClinical studiesAntigen expressionImmune responseAlloimmunizationAnimal modelsAnimal studiesRBC antigensBlood groupHigher likelihoodTransfusionAdditional associationsHigh rateThe Nlrp3 Inflammasome Does Not Regulate Alloimmunization to Transfused Red Blood Cells in Mice
Gibb DR, Calabro S, Liu D, Tormey CA, Spitalnik SL, Zimring JC, Hendrickson JE, Hod EA, Eisenbarth SC. The Nlrp3 Inflammasome Does Not Regulate Alloimmunization to Transfused Red Blood Cells in Mice. EBioMedicine 2016, 9: 77-86. PMID: 27345021, PMCID: PMC4972549, DOI: 10.1016/j.ebiom.2016.06.008.Peer-Reviewed Original ResearchConceptsRBC transfusionNLRP3 inflammasomeRed blood cell transfusionInnate immune cell activationPro-inflammatory pathogensMolecular patternsBlood cell transfusionProduction of alloantibodiesTransfusion-associated mortalityImmune cell activationInnate immune stimuliBlood group antigensBone marrow failureAlloantibody productionRBC alloimmunizationAlloantibody responsesCell transfusionAlloimmune responseRed blood cellsABO matchingImmunological factorsInflammatory conditionsLeading causeImmune stimuliEndogenous DAMPClinically significant anti‐KEL RBC alloantibodies are transferred by breast milk in a murine model
Santhanakrishnan M, Tormey CA, Natarajan P, Liu J, Hendrickson JE. Clinically significant anti‐KEL RBC alloantibodies are transferred by breast milk in a murine model. Vox Sanguinis 2016, 111: 79-87. PMID: 26950259, PMCID: PMC4938760, DOI: 10.1111/vox.12387.Peer-Reviewed Original ResearchConceptsBreast milkRBC alloantibodiesIgA antibodiesMurine modelHuman KEL glycoproteinSeries of pregnanciesBreast milk transferHuman breast milkWild-type pupsKEL RBCsNursing infantsClinical significanceAlloantibodiesNursing pupsMurine dataTransfusion experimentsMilk transferInfantsPupsTransfusionHuman dataSequelaePregnancyAnemiaPremature clearance